DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3045 and DEG1

DIOPT Version :9

Sequence 1:	NP_611646.1	Gene:	CG3045 / 37531	FlyBaseID:	FBgn0034703	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_116655.1	Gene:	DEG1 / 850550	SGDID:	S000001895	Length:	442	Species:	Saccharomyces cerevisiae

Alignment Length:	406	Identity:	143/406 - (35%)
Similarity:	208/406 - (51%)	Gaps:	56/406 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 TQTELIDKVIQLEAYNFQLRNLLQKKLSEKDKHDKEYSGLIGNEAEGKVSQVAKTSSKVQKI-RK 90
            ::.:||.::.:||..|        |..|||.:|       |.:..:.|:||...|.||.:|. :|
Yeast    34 SKEQLIRRITELENAN--------KPHSEKFQH-------IEDNKKRKISQEEVTRSKAKKAPKK 83

  Fly    91 FDWSSAHKRHVLLKITYFGWDYQGFACQEDSN--DTIESNLFRALARTCLIESRATSNY--HRCG 151
            ||:|..:.|.:.|:..|.||:|.|.|.|::..  .|:|..:..|:.:..|:.|....:|  .|||
Yeast    84 FDFSKHNTRFIALRFAYLGWNYNGLAVQKEYTPLPTVEGTILEAMNKCKLVPSMVLQDYKFSRCG 148

  Fly   152 RTDKEVSAFCQVISIDLRSKHPPESQLDPTALSSEIDYCGLLNRVLPKNIQCVAWMPLRSPVYSA 216
            ||||.|||..||||:::||....|.|.|||..|.||.|..:||::||.:|:..|......|.:.|
Yeast   149 RTDKGVSAMNQVISLEVRSNLTDEEQRDPTNDSREIPYVHVLNQLLPDDIRISAVCLRPPPNFDA 213

  Fly   217 RFDCVSRTYRYYFPKGDLDIAAMRKACDLLVRHADFRNFCKMDVHNGVTNYMRNLQSARVEACDQ 281
            ||.||.|.|:|.|...:|:|..|.||....|...|||||||:|....:||:.|.:.|:::....:
Yeast   214 RFSCVHRHYKYIFNGKNLNIEKMSKAASYFVGERDFRNFCKLDGSKQITNFKRTIISSKILPLSE 278

  Fly   282 TNHTNSGYDMYYLEIQANAFLWHQIRCIMAVLLLVGQKKENPGVISDLLDVESNPCKPQYTPAIG 346
            |        .|..::..:||||||:||:||:|.||||..|.|.::..|.|:|..|.:|.|..|..
Yeast   279 T--------FYCFDLVGSAFLWHQVRCMMAILFLVGQSLEVPEIVLRLTDIEKTPQRPVYEMAND 335

  Fly   347 LPLNLFRCDFRDHTTRSVNHPSSGDADEEAMD-------TAADESNDLN-----APEHLERDL-- 397
            :||.|:.|.|.:.           |..|..:|       |.|.|:..|:     |..::.:|:
Yeast   336 IPLLLYDCKFPEM-----------DWQEPTVDDYKAIKFTTATEALTLHYELKAAVCNIFKDVLP 389

  Fly   398 TAWIYNEENLQKLIEN 413
            ||   |..|..|.|.|
Yeast   390 TA---NTNNFSKTIIN 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3045	NP_611646.1	TruA	101..376	CDD:223179	106/278 (38%)
CG3045	NP_611646.1	PseudoU_synth_ScPus3	103..356	CDD:211336	103/256 (40%)
DEG1	NP_116655.1	PseudoU_synth_ScPus3	96..345	CDD:211336	103/256 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344105
Domainoid	1	1.000	124	1.000	Domainoid score	I1219
eggNOG	1	0.900	-	-		E1_COG0101
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11339
Inparanoid	1	1.050	212	1.000	Inparanoid score	I803
Isobase	1	0.950	-	0	Normalized mean entropy	S1490
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004137
OrthoInspector	1	1.000	-	-		oto99895
orthoMCL	1	0.900	-	-		OOG6_100424
Panther	1	1.100	-	-	LDO	PTHR11142
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1941
SonicParanoid	1	1.000	-	-		X2401
TreeFam	1	0.960	-	-
	15	14.730