Protein Alignment CG3045 and PUS3

DIOPT Version :10

• Sequence 1: NP_611646.1
• Gene: CG3045 / 37531
• FlyBaseID: FBgn0034703
• Length: 499
• Species: Drosophila melanogaster
• Sequence 2: NP_112597.4
• Gene: PUS3 / 83480
• HGNCID: 25461
• Length: 481
• Species: Homo sapiens
• Alignment Length: 477
• Identity: 189/477 - (39%)
• Similarity: 265/477 - (55%)
• Gaps: 68/477 - (14%)

  Fly    40 AYNFQLRNLLQKKLSEKDKHDKEYSGLIGNEAEGKV-SQVAKTSSKVQKI-RKFDWSSAHKRHVL 102
            |||...||..:|.|....:.::|...|...:|:.|. |.:.:.|:...|. |.||:|:..:|||.
Human     2 AYNDTDRNQTEKLLKRVRELEQEVQRLKKEQAKNKEDSNIRENSAGAGKTKRAFDFSAHGRRHVA 66

  Fly   103 LKITYFGWDYQGFACQEDSNDTIESNLFRALARTCLIESRATSNYHRCGRTDKEVSAFCQVISID 167
            |:|.|.||.|||||.||::|:|||..||.||.:|.|:|||.||||||||||||.||||.||||:|
Human    67 LRIAYMGWGYQGFASQENTNNTIEEKLFEALTKTRLVESRQTSNYHRCGRTDKGVSAFGQVISLD 131

  Fly   168 LRSKHPP-------ESQLDPTALSSEIDYCGLLNRVLPKNIQCVAWMPLRSPVYSARFDCVSRTY 225
            |||:.|.       ..:.:..|.:.||.|..:||||||.:|:.:||.|: .|.:||||.|:.|||
Human   132 LRSQFPRGRDSEDFNVKEEANAAAEEIRYTHILNRVLPPDIRILAWAPV-EPSFSARFSCLERTY 195

  Fly   226 RYYFPKGDLDIAAMRKACDLLVRHADFRNFCKMDVHNGVTNYMRNLQSARVEACDQT---NHTNS 287
            ||:||:.||||..|..|....|...||||.|||||.|||.|:.|.:.||:|:...|:   .....
Human   196 RYFFPRADLDIVTMDYAAQKYVGTHDFRNLCKMDVANGVINFQRTILSAQVQLVGQSPGEGRWQE 260

  Fly   288 GYDMYYLEIQANAFLWHQIRCIMAVLLLVGQKKENPGVISDLLDVESNPCKPQYTPAIGLPLNLF 352
            .:.:...|:...|||:||:||:||:|.|:||..|.|.:|.:||::|.||.||||:.|:..||.|:
Human   261 PFQLCQFEVTGQAFLYHQVRCMMAILFLIGQGMEKPEIIDELLNIEKNPQKPQYSMAVEFPLVLY 325

  Fly   353 RCDFRDHTTRSVNHPSSGDADEEAMDTAADESNDLNAPEHLERDLTAWIYNEENLQKLIENTQCE 417
            .|.|.:                                       ..|||::|..:..|.:.|..
Human   326 DCKFEN---------------------------------------VKWIYDQEAQEFNITHLQQL 351

  Fly   418 WTQFSVKSTMIRNVLQQLENL------------FEE--NFKPKEKVLAQVILLQDSVNPRQYQPL 468
            |...:||:.|:.::||.|:.:            ..|  |.||  .|:.|.....:.|..|.|:||
Human   352 WANHAVKTHMLYSMLQGLDTVPVPCGIGPKMDGMTEWGNVKP--SVIKQTSAFVEGVKMRTYKPL 414

  Fly   469 LERKRCESLENRIEHFVKKQRL 490
            ::|.:|:.||:||:|||::.|:
Human   415 MDRPKCQGLESRIQHFVRRGRI 436

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3045	NP_611646.1	PseudoU_synth_ScPus3	103..356	CDD:211336	133/262 (51%)
PUS3	NP_112597.4	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	29..50		4/20 (20%)
		PseudoU_synth_ScPus3	67..329	CDD:211336	133/262 (51%)