DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3045 and PUS1

DIOPT Version :9

Sequence 1:	NP_611646.1	Gene:	CG3045 / 37531	FlyBaseID:	FBgn0034703	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_079491.2	Gene:	PUS1 / 80324	HGNCID:	15508	Length:	427	Species:	Homo sapiens

Alignment Length:	352	Identity:	77/352 - (21%)
Similarity:	132/352 - (37%)	Gaps:	91/352 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 KRHVLLKITYFGWDYQGFACQEDSND--TIESNLFRALART-CLIESRATS----NYHRCGRTDK 155
            ||.::|.:.|.|..|.|......|:.  |||.:|..||.|: |:.|:....    ::.||.||||
Human    83 KRKIVLLMAYSGKGYHGMQRNVGSSQFKTIEDDLVSALVRSGCIPENHGEDMRKMSFQRCARTDK 147

  Fly   156 EVSAFCQVISI------DLRSKHPPESQLDPTALSSEIDYCGLLNRVLPKNIQCVAWMPLRSPVY 214
            .|||..||:|:      |:..|                     :|..||.:|:.:....:... :
Human   148 GVSAAGQVVSLKVWLIDDILEK---------------------INSHLPSHIRILGLKRVTGG-F 190

  Fly   215 SARFDCVSRTYRYYFP-----KGDLDI---------AAMRKACDLLVRHADFRNFCKMDVHNG-- 263
            :::..|.:|||.|..|     ..|.|:         ..:::...||..:....||.......|
Human   191 NSKNRCDARTYCYLLPTFAFAHKDRDVQDETYRLSAETLQQVNRLLACYKGTHNFHNFTSQKGPQ 255

  Fly   264 ---VTNYMRNLQSARVEACDQTNHTNSGYDMYYLEIQANAFLWHQIRCIMAVLLLVGQKKENPGV 325
               ...|:..:.      |::. ....|.:...:.::..:|:.||||.::.:::.:.:......|
Human   256 DPSACRYILEMY------CEEP-FVREGLEFAVIRVKGQSFMMHQIRKMVGLVVAIVKGYAPESV 313

  Fly   326 I-----SDLLDVESNPCKPQYTPAIGLPLNLFRCDFRDHTTRSVNHPSSGDADEEAMDTAADESN 385
            :     ::.:||...|         ||.|.|.|..|..:..|..|     |...|.:|.|.:|..
Human   314 LERSWGTEKVDVPKAP---------GLGLVLERVHFEKYNQRFGN-----DGLHEPLDWAQEEGK 364

  Fly   386 -----------DLNAPEHLERDLTAWI 401
                       .:...|..||.:..|:
Human   365 VAAFKEEHIYPTIIGTERDERSMAQWL 391

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3045	NP_611646.1	TruA	101..376	CDD:223179	67/311 (22%)
CG3045	NP_611646.1	PseudoU_synth_ScPus3	103..356	CDD:211336	63/289 (22%)
PUS1	NP_079491.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	20..83		77/352 (22%)
		TruA	84..363	CDD:223179	71/321 (22%)
		PseudoU_synth_PUS1_PUS2	88..340	CDD:211335	63/289 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	407..427
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0101
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810