DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3045 and SPAC25B8.05

DIOPT Version :9

Sequence 1:	NP_611646.1	Gene:	CG3045 / 37531	FlyBaseID:	FBgn0034703	Length:	499	Species:	Drosophila melanogaster
Sequence 2:	NP_594465.1	Gene:	SPAC25B8.05 / 2541578	PomBaseID:	SPAC25B8.05	Length:	450	Species:	Schizosaccharomyces pombe

Alignment Length:	510	Identity:	157/510 - (30%)
Similarity:	236/510 - (46%)	Gaps:	101/510 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 GLSREALEKLTQTELIDKVIQLEAYNFQLRNLLQKK--------LSEKDKHDKEYSGLIGNEAEG 73
            |.||:        :||.::::|:....:..|.|..|        :..|:|.|.      |||.|.
pombe     8 GWSRD--------QLISRILELDGKLQKNTNSLPNKEIEGKNEVIKNKNKLDN------GNEIEP 58

  Fly    74 K----------VSQVAKTSSKVQKIRKFDWSSAHKRHVLLKITYFGWDYQGFACQEDSN--DTIE 126
            :          ..|.|.:..|::.:|.|.....  ..|..|..|.||:|.|.|.|.:..  .|:|
pombe    59 QHLSQELVLQHALQDASSLPKLKPVRPFQLEKT--VFVAFKFAYCGWNYNGLAYQLEPTPLPTVE 121

  Fly   127 SNLFRALARTCLIESRATSNYHRCGRTDKEVSAFCQVISIDLRSKHPPESQLDPTALSSEIDYCG 191
            ..:|.||.|..||...::.::.|||||||.|||..||||:::|     .|:..|      |.||.
pombe   122 GKVFEALLRAHLITDPSSCSFSRCGRTDKGVSAMGQVISLNVR-----HSERRP------IIYCD 175

  Fly   192 LLNRVLPKNIQCVAW-MPLRSPVYSARFDCVSRTYRYYF----PKGDLDIAAMRKACDLLVRHAD 251
            :|||:||.:|:...: .|...  :.|||.|..|.|:|.|    |.|.|||..|.:|..|.:...|
pombe   176 VLNRLLPADIRITGYAFPPEG--FDARFSCKQRHYKYLFTKDYPGGSLDIDRMNEAAALYLGEHD 238

  Fly   252 FRNFCKMDVHNGVTNYMRNLQSARVEACDQTNHTNSGYDMYYLEIQANAFLWHQIRCIMAVLLLV 316
            ||||||:|....:|||.|.:.|::|...|.:.      .:|..::|..||||||:||:||:|.|:
pombe   239 FRNFCKIDASKQITNYHRRILSSKVICIDPST------GLYAFDLQGTAFLWHQVRCMMAILFLI 297

  Fly   317 GQKKENPGVISDLLDVESNPCKPQYTPAIGLPLNLFRCDFRDHTTRSVNHPSSGDADEEAMDTAA 381
            |||.|...:|:||||::..|.||.|..|...||.|:.|||              |..|..:.|
pombe   298 GQKLEPASLINDLLDIKKVPTKPIYDMASEYPLILYDCDF--------------DNIEWTLPT-- 346

  Fly   382 DESNDLNAPEHLERDLTAWIYNEENLQKLIENTQCEWTQFSVKSTMIRNVLQQLENLFEENFKPK 446
              .:...|| .:.:.....||:             :|....::..:...:|...::..:...|.:
pombe   347 --DSPTTAP-RIAKHTYETIYH-------------QWHSLRIREQIASFMLDIADHNVKRYGKSE 395

  Fly   447 EKVLAQVI---LLQDSVNPRQYQPLLERKRCESLENRIEHFVKKQRL---IVKNE 495
            |......:   ||:   ..::|.|:|.|:|.||:|...|.:.:|:.|   .||:|
pombe   396 ESSSTMNVGEGLLK---RTKKYIPILSRQRQESVEVVNERYKRKKGLKDSDVKSE 447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3045	NP_611646.1	TruA	101..376	CDD:223179	111/281 (40%)
CG3045	NP_611646.1	PseudoU_synth_ScPus3	103..356	CDD:211336	106/259 (41%)
SPAC25B8.05	NP_594465.1	TruA	93..359	CDD:223179	114/303 (38%)
SPAC25B8.05	NP_594465.1	PseudoU_synth_ScPus3	96..337	CDD:211336	106/259 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	103	1.000	Domainoid score	I1741
eggNOG	1	0.900	-	-		E1_COG0101
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11339
Inparanoid	1	1.050	190	1.000	Inparanoid score	I1055
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004137
OrthoInspector	1	1.000	-	-		oto101587
orthoMCL	1	0.900	-	-		OOG6_100424
Panther	1	1.100	-	-	LDO	PTHR11142
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1941
SonicParanoid	1	1.000	-	-		X2401
TreeFam	1	0.960	-	-
	13	12.850