Protein Alignment LBR and ERG24

DIOPT Version :10

• Sequence 1: NP_726114.1
• Gene: LBR / 37482
• FlyBaseID: FBgn0034657
• Length: 741
• Species: Drosophila melanogaster
• Sequence 2: NP_014119.1
• Gene: ERG24 / 855441
• SGDID: S000005224
• Length: 438
• Species: Saccharomyces cerevisiae
• Alignment Length: 479
• Identity: 111/479 - (23%)
• Similarity: 200/479 - (41%)
• Gaps: 89/479 - (18%)

  Fly   305 PR----EFGGWLGAFLFLLLLPTAVYYLTWSCTARNACQFKHLNLGILLDVNYLTRQVFQ----- 360
            ||    ||||.:||....:.||...                 :.|..::..:|..:..||
Yeast     7 PRTTEFEFGGLIGALGISIGLPVFT-----------------IILNQMIRPDYFIKGFFQNFDIV 54

  Fly   361 ---------------PRVVGAFAAYQVVVFLLVALLPGR---RVHL---TRETYKFNCLAVSLTL 404
                           ..:...:..:..::.:|..:||||   .|.|   ::.:||.|.:|:|.||
Yeast    55 ELWNGIKPLRYYLGNRELWTVYCLWYGILAVLDVILPGRVMKGVQLRDGSKLSYKINGIAMSTTL 119

  Fly   405 LIASGVAEYL---KYPVVTFVLRHYLRFCIFGLVGAFVAAAWSYW-----LVDTAKYNVLRQTLT 461
            ::...:...|   :.|.:.::..:::..||..::.:|..|.:.|.     |:.....|..|:.:.
Yeast   120 VLVLAIRWKLTDGQLPELQYLYENHVSLCIISILFSFFLATYCYVASFIPLIFKKNGNGKREKIL 184

  Fly   462 NDYGRTGSFVVDFALGRQLNPKWLGRVDWKQF-QYRLS-LVTTLIYATCYIYQTLVWPQKPQLGE 524
            ...|.:|:.:.|:.:||:|||: ||.:|.|.| :.|.. |:..||..:|..:..|
Yeast   185 ALGGNSGNIIYDWFIGRELNPR-LGPLDIKMFSELRPGMLLWLLINLSCLHHHYL---------- 238

  Fly   525 QEGYLYQAKYYWNNVNYDPATLFSASCLLFYVLDAIIFEHHLSSSFELQHEGYGCLLLL-RYAAT 588
            :.|.:..|...   ||:...         ||:.|.::.|..:.:..::..:|:|.:|.. ..:..
Yeast   239 KTGKINDALVL---VNFLQG---------FYIFDGVLNEEGVLTMMDITTDGFGFMLAFGDLSLV 291

  Fly   589 PYLLTAVTKYFYEQRVPISCWYAPLAVAALLSLGLLVKRFSCAYKYKYRLNSQSPIFANIETIHT 653
            |:..:...:|.....|.:. |...:.:.|::.||..:  |..|.|.|.......  ..|:::|.|
Yeast   292 PFTYSLQARYLSVSPVELG-WVKVVGILAIMFLGFHI--FHSANKQKSEFRQGK--LENLKSIQT 351

  Fly   654 YQGSRLLLSGMWGWVRQPNYLGDIVALLALAAPMALRPAWPPVLGLSL-IILLLLHRATRANARN 717
            .:|::||..|.|...:..||.||  .|::|:..:|.....|.....|| ...|||||..|...:.
Yeast   352 KRGTKLLCDGWWAKSQHINYFGD--WLISLSWCLATWFQTPLTYYYSLYFATLLLHRQQRDEHKC 414

  Fly   718 QARYHSSWQRYSTQVRSYILPRVY 741
            :.:|..:|:.|..:|...|:|.||
Yeast   415 RLKYGENWEEYERKVPYKIIPYVY 438

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
LBR	NP_726114.1	ICMT	304..741	CDD:473892	109/477 (23%)
ERG24	NP_014119.1	ERG4_ERG24	8..438	CDD:250456	108/476 (23%)