DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HmgZ and TOX4

DIOPT Version :9

Sequence 1:	NP_001286694.1	Gene:	HmgZ / 37480	FlyBaseID:	FBgn0010228	Length:	111	Species:	Drosophila melanogaster
Sequence 2:	NP_055643.1	Gene:	TOX4 / 9878	HGNCID:	20161	Length:	621	Species:	Homo sapiens

Alignment Length:	108	Identity:	29/108 - (26%)
Similarity:	48/108 - (44%)	Gaps:	15/108 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 DRPKRPLSAYMLWLNETREQIKKDNPGSKVTDIAKRGGELWRGL--KDKTEWEQKAIKMKEEYNK 66
            :.|::|:|||.|:..:|:..||..||.:...:::|....:|..|  :.|..:::|....|:||.|
Human   221 NEPQKPVSAYALFFRDTQAAIKGQNPNATFGEVSKIVASMWDSLGEEQKQVYKRKTEAAKKEYLK 285

  Fly    67 AVKEY-------------EANGGTDSGAPKKRKKAAAKPAKKA 96
            |:..|             |.:....|..|.....|...||..|
Human   286 ALAAYKDNQECQATVETVELDPAPPSQTPSPPPMATVDPASPA 328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HmgZ	NP_001286694.1	HMG_box	6..71	CDD:395407	21/66 (32%)
TOX4	NP_055643.1	NHP6B	140..>306	CDD:227935	23/84 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	153..227		1/5 (20%)
		Nuclear localization signal. /evidence=ECO:0000255	213..218
		HMG-box	223..288	CDD:238037	21/64 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	305..333		6/24 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	510..529
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910