DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment HmgZ and tcf7l1

DIOPT Version :9

Sequence 1:	NP_001286694.1	Gene:	HmgZ / 37480	FlyBaseID:	FBgn0010228	Length:	111	Species:	Drosophila melanogaster
Sequence 2:	NP_001005640.1	Gene:	tcf7l1 / 448107	XenbaseID:	XB-GENE-1031985	Length:	553	Species:	Xenopus tropicalis

Alignment Length:	94	Identity:	22/94 - (23%)
Similarity:	47/94 - (50%)	Gaps:	4/94 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KRPLSAYMLWLNETREQIKKDNPGSKVTDIAKRGGELWRGL--KDKTEWEQKAIKMKEEYNKAVK 69
            |:||:|:||::.|.|.::..:....:...|.:..|..|..|  :::.::.:.|.|.::.:::...
Frog   325 KKPLNAFMLYMKEMRAKVVAECTLKESAAINQILGRRWHSLSREEQAKYYELARKERQLHSQLYP 389

  Fly    70 EYEANGGTDSGAPKKRKKAAAKPAKKAKK 98
            .:.|.  .:.|..||||:....|..:..|
Frog   390 TWSAR--DNYGKRKKRKRDKQSPEMEITK 416

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
HmgZ	NP_001286694.1	HMG_box	6..71	CDD:395407	14/65 (22%)
tcf7l1	NP_001005640.1	CTNNB1_binding	1..228	CDD:369826
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..77
		Interaction with CTNNB1. /evidence=ECO:0000250	1..61
		Interaction with AES and TLE4. /evidence=ECO:0000250	109..312
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	183..213
		SOX-TCF_HMG-box	323..394	CDD:238684	14/68 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	392..474		8/27 (30%)
		Interaction with CTBP. /evidence=ECO:0000250	408..553		2/9 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910