Protein Alignment Isha and NRD1

DIOPT Version :10

• Sequence 1: NP_001097394.1
• Gene: Isha / 37411
• FlyBaseID: FBgn0034598
• Length: 1306
• Species: Drosophila melanogaster
• Sequence 2: NP_014148.1
• Gene: NRD1 / 855470
• SGDID: S000005195
• Length: 575
• Species: Saccharomyces cerevisiae
• Alignment Length: 816
• Identity: 148/816 - (18%)
• Similarity: 248/816 - (30%)
• Gaps: 289/816 - (35%)

  Fly    11 LSGLYDSRPPISKAKMAAITKSAMRAIKLYKHVVQSVEKFILKCKPEYKVPGLYVIDSIVR---- 71
            |....|.:..||.:::..:|..|:..|.:...::..:..:...|...:|:..||:||||.|
Yeast    14 LESFKDLKSGISGSRIKKLTTYALDHIDIESKIISLIIDYSRLCPDSHKLGSLYIIDSIGRAYLD 78

  Fly    72 --QSRHQYGMDKDLFAPRFQRNLTETFANLFRCA-----PEDKSRIIRVLNLWQKNNVFKSEVIQ 129
              :|......:|..........|.|....|...|     .:.|.:|..:|::|.::.:|:...:.
Yeast    79 ETRSNSNSSSNKPGTCAHAINTLGEVIQELLSDAIAKSNQDHKEKIRMLLDIWDRSGLFQKSYLN 143

  Fly   130 PIFDLADPNHPIYHQMPPVGGSGGQGGGVGPGPSSSGALSLADISSGPNGLNSSGMEISMNSSGG 194
            .|                                .|...:: |||:  |..|::..::|:
Yeast   144 AI--------------------------------RSKCFAM-DISN--NTANTASQQLSL----- 168

  Fly   195 DDKMGGAMPDLSLGHEKFGGGSSSSKRHYSEQHYSKRQSVVSCSSKTSKSHHHKREYVKSSHDID 259
            |.|                               .:.:.::|...|
Yeast   169 DPK-------------------------------QRSKQILSNLKK------------------- 183

  Fly   260 YQVREIIEEEDEGLQMLMADDHHCMGDDSPPTSSNLLDEKKIKQLLNNPNVLRQLHTLQNFQNLK 324
                                        |||.:.|:    .:...|.:.:..:|...|  ||.:
Yeast   184 ----------------------------SPPLNLNI----SLPTDLTSTDPAKQQAAL--FQVI- 213

  Fly   325 PQEENQKHRYQDEALQQHFQNVMKGNAGMPPGMGMGMNMNDSMDLNKDVEFISEQQTIEVINLDG 389
                        .|||:||:.       :|....:|.              ::..|...:  .:.
Yeast   214 ------------AALQKHFKT-------LPSHTSVGT--------------VAPPQAHTI--TEY 243

  Fly   390 GDSRSPTPDRDRYKRSRRNSRSRTRSPRGRGAGGGTG-NDRRRRGTRSRSRSRSPRSSRRRGSRD 453
            |..|....:|:|| .||||   |:|||....:...|| .||.....:.:....:|.::  .|:.:
Yeast   244 GSRRERERERERY-NSRRN---RSRSPPAPFSQPSTGRKDRYPSVAQDQYSIGAPNTT--FGTNN 302

  Fly   454 R----DRMDRSNRDKERDREHERERRKKGLPDIKKEHLSVCSTTLWVGHLSKLVYQEELSDTFGE 514
            .    |.::.||      ..|.|.:.......:..:|:.|.|.||::|.:...:.:.:|::....
Yeast   303 HHLYPDELNVSN------NPHYRPKPVSYDSTLPPDHIKVYSRTLFIGGVPLNMKEWDLANVLKP 361

  Fly   515 YGDIVSIDQIVPRGCAFIVMNRRQDAHKAMQALKNHKLQGR-AITISWAAGKGVKSKEWKDYWDL 578
            :.::.|:.....|..||:.:..|   |:|...|:|....|. .:...|..|.|.     :|..|.
Yeast   362 FAEVQSVILNNSRKHAFVKVYSR---HEAENVLQNFNKDGALPLRTRWGVGFGP-----RDCCDY 418

  Fly   579 ELGVTYIPWSKLSSDTDFDALEEGGMFDEDTMPIQMKQKINQAKNAAKEHKGASIAEAAGAPSV- 642
            :.|.:.||..:|   ||.|                           .|....|.....:|.|.|
Yeast   419 QHGYSIIPMHRL---TDAD---------------------------KKWSVSAQWGGTSGQPLVT 453

  Fly   643 GV--PPPNLIFG-------IDTTQPPPVGPVGPVGPPPGPGAPPPGLMGMVRGQFPMAPPMGINM 698
            |:  ..|::|.|       |....|...|..||....|........:..:..|..|:|.|
Yeast   454 GIVFEEPDIIVGEGVSSKAISQKMPTDSGRNGPRSGKPNKSGSISSISPVPYGNAPLASP----- 513

  Fly   699 PPPIMMPPTNMPPPMMMPTTNMPPPMMMPPTMMPPGFPGIGGPPHPMALPPGAPFPP--PGAVPP 761
                  ||.....|||.                           .|....|..|.|.  |.|..|
Yeast   514 ------PPQQYVQPMMQ---------------------------QPYGYAPNQPLPSQGPAAAAP 545

  Fly   762 PIPSGGQISNSGNVSDDQMDIEMDLEDAPPLPPQQQ 797
            |:|            ..|.|....|.....:..|||
Yeast   546 PVP------------QQQFDPTAQLNSLMNMLNQQQ 569

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Isha	NP_001097394.1	PHA03247	<1187..1306	CDD:223021
		CID_SCAF8_like	6..135	CDD:340780	28/134 (21%)
		RRM_SCAF4_SCAF8	490..566	CDD:409674	17/76 (22%)
NRD1	NP_014148.1	CID_Nrd1_like	8..149	CDD:340781	29/166 (17%)
		RRM_NRD1_SEB1_like	336..412	CDD:409768	18/78 (23%)