DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG4266 and scaf4

DIOPT Version :9

Sequence 1:NP_001097394.1 Gene:CG4266 / 37411 FlyBaseID:FBgn0034598 Length:1306 Species:Drosophila melanogaster
Sequence 2:XP_012813473.1 Gene:scaf4 / 595037 XenbaseID:XB-GENE-920206 Length:1340 Species:Xenopus tropicalis


Alignment Length:1499 Identity:458/1499 - (30%)
Similarity:616/1499 - (41%) Gaps:400/1499 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 METVVAFNNELSGLYDSRPPISKAKMAAITKSAMRAIKLYKHVVQSVEKFILKCKPEYKVPGLYV 65
            |:.|.|||.||..|.|.:||||:|||..|||:|::||||||||||.|||||.|||||||||||||
 Frog     1 MDAVNAFNQELFSLMDMKPPISRAKMILITKAAIKAIKLYKHVVQIVEKFIKKCKPEYKVPGLYV 65

  Fly    66 IDSIVRQSRHQYGMDKDLFAPRFQRNLTETFANLFRCAPEDKSRIIRVLNLWQKNNVFKSEVIQP 130
            |||||||||||:|:|||:|.|||.:|||.||..|:.|..||||:|:|||||||||.|||.|:|||
 Frog    66 IDSIVRQSRHQFGIDKDVFGPRFTKNLTATFQCLYTCPSEDKSKIVRVLNLWQKNGVFKIEIIQP 130

  Fly   131 IFDLADPNHPIYHQMPPVGGSGGQGGGV---------GPGPSSSGALS-----------LADISS 175
            :.|:|               :|.....|         |..|.|...||           :|.:..
 Frog   131 LLDMA---------------AGAAAADVMTDSSMMEEGSSPPSGMILSEPPDEVQEPPPVAPVPQ 180

  Fly   176 GPNGLNSSGMEISMNSSGGDDKMGGAMPDLSLGHEKFGGGSSSSKRHYSEQHYSKRQSVVSCSSK 240
            .|.....:.:.....|:.|.        .|....:.|............|..:::.|::.|..:.
 Frog   181 LPTPDAFAAVAQLFQSTQGQ--------QLQQILQTFQQPPKPQSPAIDENVFAQVQAITSQLNA 237

  Fly   241 TSKSHHHKREYVKSSHDIDYQVREIIEEEDEGLQMLMADDHHCMGDDSPPTSSNLLDEKKIKQLL 305
            .:.....|..:.|.....||.     :|.|       |.:.......|||.|.:...:..::...
 Frog   238 PAHQPERKTAFDKLLDRFDYD-----DEPD-------ATEESKKEASSPPLSGSQQSQPPLQPFA 290

  Fly   306 NNPNVLR----------QLHTLQNFQNL---KPQEENQKHRYQDEALQQHFQNVMKGN------- 350
            .:.:.::          |:..:..||.:   .||          |.|.|..|....|.       
 Frog   291 FSADSMQPAAYPGQLPGQVPNMDQFQPMMMGMPQ----------EPLPQQTQLPPNGQMLGFGMV 345

  Fly   351 -----AGMPPGMG-----------MGMNMNDSMDLNKDVEFISEQQTIEVINLDGGDSRSPTPDR 399
                 |.|.|.||           ..|..|: |.:.|:     .||.:.:      |...|....
 Frog   346 PTQSFAPMVPPMGSEPSTHGFQNTFQMQPNE-MHVQKE-----HQQEMPM------DVEQPNVQE 398

  Fly   400 DRYKRSRRNSRSRTRSPRGRGAGGGTGNDRRRRGTRSRSRSRSPRSSRRRGSRDRDRMDRSNRDK 464
            :: :.....|:|.:|||:.|         |.|.|:||| |||..||..|  ||||.|....:|.:
 Frog   399 NK-RHMNEQSKSVSRSPKRR---------RSRSGSRSR-RSRHRRSRSR--SRDRRRHSPKSRSQ 450

  Fly   465 E-RDREHERERRKKGLPDIKKEHLSVCSTTLWVGHLSKLVYQEELSDTFGEYGDIVSIDQIVPRG 528
            | ||||.|:|||:||||.||.|.:|:||||||:|.|.|...|:::.....|:|.|.||:.|.|||
 Frog   451 ERRDREKEKERRQKGLPPIKSETVSICSTTLWIGQLDKKTTQQDVGSFLEEFGPIESINMIPPRG 515

  Fly   529 CAFIVMNRRQDAHKAMQALK--NHKLQGRAITISWAAGKGVKSKEWKDYWDLELGVTYIPWSKLS 591
            ||:|||..||||::|:..|.  |.|:..:||.|:||..||:|: |:|.|||:|:|||||||:|:.
 Frog   516 CAYIVMVHRQDAYRALMKLSRGNVKVNQKAIKIAWALNKGIKA-EYKQYWDVEIGVTYIPWNKVK 579

  Fly   592 SDTDFDALEEGGMFDEDTM-----PIQMK-QKINQAKNAAKEHKGASIAEAAGAPSV----GVPP 646
            .: |.:...||||.|.||:     |:..| :..:.::|.|.|.||  :.||:.||.|    .:|.
 Frog   580 PE-DLENFCEGGMLDNDTLCPEWKPLAKKPEPKDVSQNGAAETKG--VGEASPAPQVLPLLSIPI 641

  Fly   647 PNLIFGIDTTQPPPVGPVG-----PVGPPPG----PGAPPPGLMGMVRGQFPMAPPMGINMPPPI 702
            ...|.|:   |.||:.|:.     |..|.||    .|.|||..:..::|    .||:. .||.|.
 Frog   642 RAPIPGM---QVPPLQPMTAHQPVPSIPTPGVPTVQGLPPPQGLPPLQG----VPPLQ-GMPLPQ 698

  Fly   703 MMPPTNMPPPMMMP-TTNMPP-----------PMMMPPTMMPPGF-PGIGGPP------HPMALP 748
            .:||..:|.|..|| ...|||           |...|..:.|||| ||:..||      :||.:|
 Frog   699 GLPPQGLPLPQGMPLPQGMPPHQPIPGMGPLQPPAFPIGIPPPGFAPGVPPPPFMRPGFNPMHMP 763

  Fly   749 PGAPFPPPGAVPP-------PIPSGGQISNSGNVSDDQMDIEMDLEDAPPLP---------PQQQ 797
            ||. .||||..||       |:|:.|....:........|...|:....|.|         ..::
 Frog   764 PGF-LPPPGLPPPMTPPVSIPLPTPGINIPTSTADTSSNDSSKDVSRTNPSPMVPVRDNMEEDEK 827

  Fly   798 AN----FNPSPSNVDLSPAAMANEMFQQRDRERDRDNRDRSRG--PG-------NSRWGGRDDVV 849
            |:    :.|:||....:.....|.:...:..|:.. |..:::|  ||       ....|.|....
 Frog   828 ADNGNGYKPTPSGGPNNAPGPLNPLHGDQQGEQGL-NSGQAQGAHPGPPQGPFSGQPQGPRHGTT 891

  Fly   850 EAAERWRAENG----------------------GGGGGPGSG----------LGPNAAFNEARAR 882
            |.|.:...|..                      |...||..|          |||...     .|
 Frog   892 EGAHQGPQEGSHQGPPEDTDHSPPGGRHYTLPEGPHHGPSEGHHHSPSEGPHLGPTEG-----PR 951

  Fly   883 LNLNPIEHGMPR--------------PDFMDFDNRGGPGGPRGMGPRGNHNG------------- 920
            |......||.|.              |:.:   :.|.|.||....|.|.::|             
 Frog   952 LGPEGPHHGPPEGSHHGPQEHPHHGPPEGL---HHGPPEGPHHGTPEGQYHGPPEGPYHGPPEGP 1013

  Fly   921 --GGPGGDFF-PPNMNHNRFNQPTSLMQMRIPPPASFNQRMGGPAG-----NGGNGVGPMFMRNQ 977
              |.|.|.|. ||   |..::.         ||...|:   |.|.|     :.|...||.....|
 Frog  1014 YHGPPDGPFHGPP---HGPYHG---------PPQGPFH---GPPQGPYQGPHHGPPQGPHHGPPQ 1063

  Fly   978 G---GGPGG------AGPSGGGPGGAGTG-----------GGGPG--GRQQGPG--------FFN 1012
            |   |.|.|      .||..|.|.|.|:|           |..||  ..|:.||        |..
 Frog  1064 GPHHGPPQGPHHGPPQGPHHGPPQGPGSGPHPGPPSTGLLGARPGLIPLQRPPGIPSSNMQRFPM 1128

  Fly  1013 PRNPFNDNQRGRG---GQSG-----GGVRGVGGGGGGGPGGRGRWSDDEDEGGNNFKRRGGPGGP 1069
            .:.|...:...||   ||.|     .|:||...|.|..|..||      .||      .|||...
 Frog  1129 SQRPGPPHMMNRGPPPGQGGFGMPPHGIRGPLLGQGHFPRQRG------PEG------HGGPEER 1181

  Fly  1070 GGNRFRGER-----GGEMMDDRRGNNSRGGRGGPREDRERPGFGNRRGSRDDSNRHSISSTDEGN 1129
            .|.:|||||     |.|  .||.|..|.|     |.:.||..||.|   .||.:.          
 Frog  1182 DGRQFRGERPVFPHGRE--PDRFGRRSFG-----RNEDERERFGRR---FDDPDH---------- 1226

  Fly  1130 KAASETEPKPKNVETELGSTNTGAPAAATRVDTEE--DWDQELQDYEARMEAQKPGERASQSANS 1192
                  |..|....:..|   .|:|:...:.|:||  .|....:     .|...|..|.....|.
 Frog  1227 ------ERPPSRGRSSWG---RGSPSRDRQRDSEERNRWPMGHE-----RERGHPRGRGDFLENR 1277

  Fly  1193 PPQEKLPAENENFAKPADVTGDPLVAKSQTETSAACTPLYDELPPPAVPQTP---TQPPKEPQGS 1254
            .|..:|...::.|:...      ..|::.||..........:.||...|:||   .:..|:|..:
 Frog  1278 KPDAELDENHKPFSSRM------RNAETVTERKEGKAEPAGKNPPEEQPETPKSSEEAEKDPGSN 1336

  Fly  1255 PPRP 1258
            |.:|
 Frog  1337 PAKP 1340

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4266NP_001097394.1 CID 7..125 CDD:239621 87/117 (74%)
RRM <488..>593 CDD:223796 55/106 (52%)
RRM_SCAF4_SCAF8 490..566 CDD:240673 37/77 (48%)
DUF2413 1147..>1254 CDD:287302 24/111 (22%)
Herpes_DNAp_acc <1206..1304 CDD:282746 12/56 (21%)
scaf4XP_012813473.1 CID_SFRS15_SCAF4 5..135 CDD:340802 94/129 (73%)
RRM_SF 475..555 CDD:388407 38/79 (48%)
PHA03247 <603..907 CDD:223021 85/315 (27%)
dnaA 873..>1044 CDD:237605 38/193 (20%)
SF-CC1 1208..>1332 CDD:273721 33/161 (20%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 149 1.000 Domainoid score I4413
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 469 1.000 Inparanoid score I1488
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002970
OrthoInspector 1 1.000 - - otm47821
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1964
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
66.050

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