Protein Alignment Isha and Scaf8

DIOPT Version :10

• Sequence 1: NP_001097394.1
• Gene: Isha / 37411
• FlyBaseID: FBgn0034598
• Length: 1306
• Species: Drosophila melanogaster
• Sequence 2: XP_006227920.3
• Gene: Scaf8 / 245926
• RGDID: 708362
• Length: 1351
• Species: Rattus norvegicus
• Alignment Length: 1454
• Identity: 431/1454 - (29%)
• Similarity: 592/1454 - (40%)
• Gaps: 419/1454 - (28%)

  Fly     1 METVVAFNNELSGLYDSRPPISKAKMAAITKSAMRAIKLYKHVVQSVEKFILKCKPEYKVPGLYV 65
            ||.|..||:||..|.|.:||||||||..|||:|::|||.||||||||||||.|||||||||||||
  Rat    84 MEAVKTFNSELYSLNDYKPPISKAKMTQITKAAIKAIKFYKHVVQSVEKFIQKCKPEYKVPGLYV 148

  Fly    66 IDSIVRQSRHQYGMDKDLFAPRFQRNLTETFANLFRCAPEDKSRIIRVLNLWQKNNVFKSEVIQP 130
            |||||||||||:|.:||:|||||..|:..||.||:||..:|||:|:|||||||||||||||:|||
  Rat   149 IDSIVRQSRHQFGQEKDVFAPRFSNNIISTFQNLYRCPGDDKSKIVRVLNLWQKNNVFKSEIIQP 213

  Fly   131 IFDLA---------------------DPNHPIYHQMPPVGGSGGQGGGVGPGPSSSGALSLADIS 174
            :.|:|                     .|..|:....|.....|.....|....::....::|.|.
  Rat   214 LLDMAAGIPPPVVTPVLASTTAAMSNTPGTPVTPVTPANVVQGLPDPWVSQITNTDTLAAVAQIL 278

  Fly   175 SGPNGLN-----------------------SSGMEISMNSSGGDDKMGGA----MPDLSLG---- 208
            ..|.|..                       .:|:.:.:.:.........|    :..|..|
  Rat   279 QSPQGQQLQQLIQTLQIQQQKPQPSILQALDAGLVVQLQALTAQLTAAAAAANTLTPLDQGVSFN 343

  Fly   209 ---HEKFGGGSSSSKRHYSEQHYSKRQSVVSCSSKTSKSHHHKREYVKSSHDIDYQVREIIEEED 270
               .::|..|..|   .:||:  ||::......|..|:|         .::.|.:|:.|.::::
  Rat   344 KKLMDRFDFGEDS---EHSEE--SKKEIPTPQLSHVSES---------VNNSIFHQIAEQLQQQ- 393

  Fly   271 EGLQMLMADDHHCMGDDSPPTSSNLLDEKKIKQLLNNPNVLRQLHTLQNFQNLKPQEENQKHRYQ 335
                                   ||  |:..:|||..          |..|.:.|| ::|:..:.
  Rat   394 -----------------------NL--EQLRQQLLEQ----------QQPQKVTPQ-DSQEGAFG 422

  Fly   336 DE--------ALQQHFQNVMKGNAGMPPGMGMGMNMNDSMDLNKDVEFISEQQTI---EVINLDG 389
            .|        :.||||         :.|    ..|::||:|:.:....|.|.|.:   |:..
  Rat   423 SEHSASPSQGSSQQHF---------LEP----EANLDDSIDIQQQDMDIDEGQDVVEEEIFE--- 471

  Fly   390 GDSRSPTPDRDRY---KRSRRNSRSRTRSPRGRGAGGGTGNDRRRRGTRSRSRSRSPRSSRRRGS 451
                   |:..:.   .|||.:||||:||||.|.:...:|:.:|:...|||||||    .|:|.|
  Rat   472 -------PEAKKVAVRSRSRTHSRSRSRSPRKRRSRSRSGSRKRKHRKRSRSRSR----ERKRKS 525

  Fly   452 RDRDRMDRSNRDKERDREHERERRKKGLPDIKKEHLSVCSTTLWVGHLSKLVYQEELSDTFGEYG 516
                  .||...:.|.||.|:||:|||||.::.:.|||||||||||.:.|...|::|::.|.|:|
  Rat   526 ------SRSYSSERRAREREKERQKKGLPPVRSKTLSVCSTTLWVGQVDKKATQQDLTNLFEEFG 584

  Fly   517 DIVSIDQIVPRGCAFIVMNRRQDAHKAMQALK--NHKLQGRAITISWAAGKGVKSKEWKDYWDLE 579
            .|.||:.|.|||||::.|..|||:.:|:|.|.  ::|:..:.|.|:||..||||: |:|.:||::
  Rat   585 QIESINMIPPRGCAYVCMVHRQDSFRALQKLSSGSYKIGSKVIKIAWALNKGVKT-EYKQFWDVD 648

  Fly   580 LGVTYIPWSKLSSDTDFDALEEGGMFDEDTMPIQ---------MKQKINQAKNAAKEHKGASIAE 635
            ||||||||.|:..| |.|...||||.|::|:..:         :|:.:...::.|...|...:.
  Rat   649 LGVTYIPWEKVKVD-DLDGFAEGGMIDQETVNAEWETVKTSEPVKETVQTTQSPAAVEKETVVT- 711

  Fly   636 AAGAPSVGVPPPNLIFGIDT--TQP-----PPVGPVGPVGPPPG--PGAPPPGLMGMVRGQF-PM 690
               ..|...|||..:..|..  |.|     ||..||....||||  |..|||    .:|..| |.
  Rat   712 ---TQSEVFPPPVTMLQIPVAPTVPAVSLVPPAFPVSMPVPPPGFSPIPPPP----FLRASFNPS 769

  Fly   691 APPMGINMPPPIMMPPTNMPPPM---MMPTTNMPPPM-MMPPTMMPPGF-----PG--IGGPPHP 744
            .||.|. ||||:  ||..:|||.   ::||:.:.||: |.|.|:...||     ||  :.|...|
  Rat   770 QPPPGF-MPPPV--PPPVVPPPAIPPVVPTSLVQPPLSMTPETVKDVGFGSLVLPGGSVAGNLAP 831

  Fly   745 MALPPGAPFPPPGAVPP----------PIPSGGQISNSGNVSDDQMDIEMDLEDAPPL---PP-- 794
            ..||.|..|.||....|          .||||   .|:..|      |..|:..:.|:   ||
  Rat   832 STLPAGNVFNPPSKAEPEEKVPHLTEHQIPSG---ENTRPV------IPSDIPSSAPMLAQPPGA 887

  Fly   795 --------QQQANFNPSPSNVDLSPAAMANEMFQQRDRERDRDNRDRSRG--------------- 836
                    .|:.|.:.:...:.:.||.::|.......:..:..|.....|
  Rat   888 SNTSGILCVQRPNVSSNSEILGVRPANVSNSAAIMGAQPPNMLNNSGILGIQPPNVSSGSGLLGV 952

  Fly   837 -----PGNSRWGGRDDVVEAAERWRAENGGGGGGPGSGLGPN--------AAFNEARARLNLN-- 886
                 |.||...|       .:.....|..|..|....:||.        |....|...|::.
  Rat   953 LPPNLPNNSGLVG-------LQPPNVTNPAGLLGTQPPIGPQNLPPLTIPAQRMPALPMLDIRPG 1010

  Fly   887 -----------------PIEHGMPRPDFMDFDNRGGPGGPRGMG--------------------- 913
                             |.:.|:|.|..:|......|.||...|
  Rat  1011 LIAQAPGPRFPLLQPGIPPQRGIPPPSVLDAALHPPPRGPFPPGDLFSQPERPFLAPGRPNIDSV 1075

  Fly   914 -------PRGNHNGGGPGG-DF-FPPNMNHNRFNQPTSLMQMRIPPPASFNQRMGGPAG-NGGNG 968
                   |.||.|....|. |: |||.......|:         |||......:|.|.. ..|.|
  Rat  1076 PNPDKRIPLGNDNIQQEGDRDYRFPPIETREGINR---------PPPVDVRDVVGRPIDPREGPG 1131

  Fly   969 VGPMFMRNQGGGPGGAGPSGGGPGGAGTGGGGPG----GRQQGPGFFNPRNPFN----DNQRGRG 1025
            ..|:..|:..|.|         |.........||    ||:...| |.|..|:.    |.:..|
  Rat  1132 RPPLDGRDHFGRP---------PVDMRETLVRPGLDHLGRRDHFG-FPPEKPWGPRDFDEREHR- 1185

  Fly  1026 GQSGGGVRGVGGGGGGGPGGRGRWSDDEDEGGNNFKRRGGPGGPGGNRFRGERGGEMMDDRRGNN 1090
                  |..|.||..|....|||:.    .|...|..|.||    .||..|:......||||
  Rat  1186 ------VLPVFGGPKGLHEERGRFR----AGNYRFDPRSGP----WNRGFGQEVHRDFDDRR--- 1233

  Fly  1091 SRGGRGGPREDRERPGFGNRRGSRDDSNRHSISSTDEGNKAASETEPKPKNVETELGSTNTGAPA 1155
                         ||  ..|:..|||.: ........||:...:.            ..||..|.
  Rat  1234 -------------RP--WERQRDRDDRD-FDFCREINGNRLGRDR------------IQNTWVPP 1270

  Fly  1156 AATRVDTEEDWDQELQDYEARMEAQKPGERASQ------SANSPP-----------QEKL----P 1199
            ...||          .||.....:|:.||...|      ..::||           .|||    .
  Rat  1271 PHARV----------FDYFEGATSQRKGENVPQVNGENTERHAPPPPLPVQKDPELYEKLASSGD 1325

  Fly  1200 AENENFAKPADVTGDPLVAKSQTE 1223
            |:.|.....|.|..:.:|..::||
  Rat  1326 ADKEESGTAAGVESEAVVESTETE 1349

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Isha	NP_001097394.1	PHA03247	<1187..1306	CDD:223021	13/58 (22%)
		CID_SCAF8_like	6..135	CDD:340780	95/128 (74%)
		RRM_SCAF4_SCAF8	490..566	CDD:409674	35/77 (45%)
Scaf8	XP_006227920.3	CID_SCAF8	88..218	CDD:340801	95/129 (74%)
		RRM_SCAF8	558..636	CDD:409895	35/77 (45%)