Protein Alignment Isha and nrd-1

DIOPT Version :10

• Sequence 1: NP_001097394.1
• Gene: Isha / 37411
• FlyBaseID: FBgn0034598
• Length: 1306
• Species: Drosophila melanogaster
• Sequence 2: NP_491403.1
• Gene: nrd-1 / 172064
• WormBaseID: WBGene00017004
• Length: 988
• Species: Caenorhabditis elegans
• Alignment Length: 1419
• Identity: 343/1419 - (24%)
• Similarity: 481/1419 - (33%)
• Gaps: 561/1419 - (39%)

  Fly     1 METVV--AFNNELSGLYDSRPPISKAKMAAITKSAMRAIKLYKHVVQSVEKFILKCKPEYKVPGL 63
            |||.|  :||||||.|:||: .:||.|:..|||:|::|...|||||.||||.|.||||:.::..|
 Worm     1 METEVMKSFNNELSSLFDSK-NMSKNKIQDITKAAIKAKSQYKHVVFSVEKLINKCKPDQRLNVL 64

  Fly    64 YVIDSIVRQSRHQYGMDKDLFAPRFQRNLTETFANLFRCAPEDKSRIIRVLNLWQKNNVFKSEVI 128
            ||||||||.|:||. .:||.|.|||.:...:....|.:|..::|.|.:|.||||..|.|||...|
 Worm    65 YVIDSIVRASKHQL-KEKDTFGPRFMKQFDKFLMPLLKCGQKEKMRTVRTLNLWMSNKVFKESEI 128

  Fly   129 QPIFDL---------------------ADPN--HPIYHQMPPVGGSGGQ------------GGGV 158
            ||:.::                     ||.:  ..:|.:.|....|..|            .|.:
 Worm   129 QPLREMCKASGLTIDFEEVELAVKGKQADMSIYSGVYKKKPKRSSSSSQPKSRTPTNPHPDDGLL 193

  Fly   159 GPGPSSSGALSLADISSGPN---------GLNSSGMEISMNSSGGDDKMGGAMPDLSL---GHEK 211
            |.||||: ..|:.||   ||         |..|....:.:....|.|:.|....|.:|   ..:.
 Worm   194 GAGPSSA-LRSVPDI---PNFVLSEDYFLGTISEREMLELVQKFGIDRSGVLSKDKNLLQRALQI 254

  Fly   212 FGGG-SSSSKRHYSEQHYSKRQSVVSCSSKTSKSHHHKREYVKSSHDIDYQVREIIEEEDEGL-- 273
            |.|. |...:...:|.:.....|:.:..:|..       ||   |.|.:.:.:|...|:.:.|
 Worm   255 FAGSLSQKVEEVLAENNRINGSSIQNVLTKDF-------EY---SDDEEEKEKEPQPEKQKNLPH 309

  Fly   274 -------QMLMADDHHCM------------------GDDSPPTSS----------NLLDEKKI-- 301
                   |.|:.......                  |:...||||          ||:..::.
 Worm   310 AQVLLLAQSLLTQPQILAKLAEVLIPQGNPFGLPFPGEHIVPTSSAALTLGAPPPNLMALQQSLP 374

  Fly   302 ----KQLLNNPNV--LRQLHTLQNFQNLKPQEENQKHRYQDEALQQH---FQN-VMKGNAGMPP- 355
                .|.|..||:  |.|.. |.|.||.:...:.|:...|.:|||.:   .:| :|.||..:.|
 Worm   375 PGFPNQQLGLPNLSGLNQAQ-LMNVQNAQNMLQLQQRAAQLQALQGNPNAQRNLLMLGNPLLNPF 438

  Fly   356 GMGMGMN--MNDSMDLNKDVEFISEQQTI----------EVINLDGGDSRSPTPDRDRYKRSRRN 408
            .:..|:|  :||     ......::||.:          :::.|.||:|
 Worm   439 ALQHGVNPMLND-----LQAAAAAQQQAMLNEAAQSPEKKILELSGGNS---------------- 482

  Fly   409 SRSRTRSPRGRGAGGGTGNDRRRRGTRSRSRSRSPRSSRRRGSRDRDRMDRSNRDKERDREHERE 473
                           |..|.                     |..:|.|:    |:||::|| .:|
 Worm   483 ---------------GINNS---------------------GDVERARL----REKEKERE-SKE 506

  Fly   474 RRKKGLPDIKKEHLSVCSTTLWVGHLSKLVYQEELSDTFGEYGDIVSIDQIVPRGCAFIVMNRRQ 538
            ||:.|||.::.....:.|.|||:..:...:.:.:|.......|:...:..|..|.||:|.|..|:
 Worm   507 RRRMGLPPVRIGFTIIASRTLWLKKIPTNIVENDLKQAVESCGEASRVKVIGNRACAYITMENRR 571

  Fly   539 DAHKAMQALKNHKLQGRAITISWAAGKGVKSKEWKDYWDLELGVTYIPWSKLSSDTDFDALEEGG 603
            .|:..:..::...:..:.:.:.||...|:.|.::.|.||...||..||:.||  ..|..||.||.
 Worm   572 SANDVVSKMREVSVAKKMVKVYWARSPGMDSDQFSDLWDSNRGVLEIPYEKL--PLDLVALCEGA 634

  Fly   604 MFDEDTMPIQMKQKINQAKNAAKEHKGASIAEAAGAPSVGVPPPNLIFGIDTTQPPPVGPVGPVG 668
            |.|.:::||:.|                .:.:..|...:.:||||:       ||       ||.
 Worm   635 MLDIESLPIEKK----------------LLYKETGETVISIPPPNI-------QP-------PVP 669

  Fly   669 PPPGPGAPPPGLMGMVRGQFPMAPPMGINMPPPIMMPPTNMPPPMMMPTTNMPPPMMMPPTMMPP 733
            .||..|.|....:..:.||           |.|..:|| .:||   |...|.||         ||
 Worm   670 HPPPMGFPFQHQLTQLPGQ-----------PRPAGLPP-GVPP---MFNLNAPP---------PP 710

  Fly   734 GFPGIGGPPHPMALPPGAPFPPPGAVPPPIPSGGQISNSGNVSDDQMDIEMDLEDAPPLPPQQQA 798
            |.||.  ||.|         ||||..||| |.|                         :||.
 Worm   711 GIPGY--PPAP---------PPPGVGPPP-PQG-------------------------IPPM--- 735

  Fly   799 NFNPSPSNVDLSPAAMANEMFQQRDRERDRDNRDRSRGPGNSRWGGRDDVVEAAERWRAENGGGG 863
                                                                             
 Worm   736 ----------------------------------------------------------------- 735

  Fly   864 GGPGSGLGPNAAFNEARARLNLNPIEHGMPRPDFMDFDNRGGPGGPRGMGPRGNHNGGGPGGDFF 928
                 |..||..                 |.|.|....|.|.|..|.|       .|.||...|.
 Worm   736 -----GFDPNKP-----------------PPPMFQQGFNAGAPPPPFG-------RGAGPMSSFP 771

  Fly   929 PP---NMNHNRFNQPTSLMQMRIPPPASFNQRMGGPAGNGGNGVGPMFMRNQGGGPGGAGPSGGG 990
            ||   .|:|             :|||.||.   ||..|:|| ...|.|.|..||||
 Worm   772 PPPRGGMHH-------------MPPPPSFR---GGRGGHGG-PPPPHFDRRGGGGP--------- 810

  Fly   991 PGGAGTGGGGPGGRQQGPG-FFNPRNPFNDNQRGRGGQSGGGVRGVGGGGGGGPGGRGRWSDDED 1054
                      |...:.|.| ..:....:|..||...          ||||.|..|||.....|.|
 Worm   811 ----------PFRPENGRGRLLDQSEMWNREQREMR----------GGGGAGRDGGREHRDYDRD 855

  Fly  1055 EGGNNFKRRGGPGGPGGNRFRGERGGEMMDDRRGNNSRGGRGGPREDRERPGFGNRRGSRDDSNR 1119
            ....:.:|:...|..     |..|.|:  ||||.::.|               .:||..|.:|.|
 Worm   856 RSQIDRRRQDDMGAR-----RRSRWGD--DDRRDDDRR---------------DDRRDDRRESRR 898

  Fly  1120 HSISSTDEGNKAASETEPKPKNVETELGSTNTGAPAAATRVDTEEDWDQELQDYEARMEAQKPGE 1184
            .|..|              |:            :|...||
 Worm   899 RSPRS--------------PR------------SPDRRTR------------------------- 912

  Fly  1185 RASQSANSPPQEKLPAENENFAKPADVTGDPLVAKSQTETSAACTPLYDELPPPAVPQTPTQPPK 1249
                  .||..|:               .:|.|.|:..|.....:...|||.|...|
 Worm   913 ------RSPSYER---------------EEPPVKKTSVEEETVSSTTLDELKPSVEP-------- 948

  Fly  1250 EPQGSPPRPAPPVIETEAAPHEESVPAPPAELQTEAPSAEEPIAPAASADVVAE 1303
                 .|.|||             :|||..||:    :||||:      .:|||
 Worm   949 -----TPVPAP-------------IPAPAPELK----AAEEPV------KIVAE 974

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Isha	NP_001097394.1	PHA03247	<1187..1306	CDD:223021	28/117 (24%)
		CID_SCAF8_like	6..135	CDD:340780	65/149 (44%)
		RRM_SCAF4_SCAF8	490..566	CDD:409674	16/75 (21%)
nrd-1	NP_491403.1	CID_SCAF8_like	7..135	CDD:340780	65/129 (50%)
		RRM_SF	523..599	CDD:473069	16/75 (21%)
		Extensin_2	740..>787	CDD:252669	20/83 (24%)