DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4266 and Scaf8

DIOPT Version :9

Sequence 1:	NP_001097394.1	Gene:	CG4266 / 37411	FlyBaseID:	FBgn0034598	Length:	1306	Species:	Drosophila melanogaster
Sequence 2:	NP_598884.2	Gene:	Scaf8 / 106583	MGIID:	1925212	Length:	1268	Species:	Mus musculus

Alignment Length:	1485	Identity:	429/1485 - (28%)
Similarity:	592/1485 - (39%)	Gaps:	481/1485 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 METVVAFNNELSGLYDSRPPISKAKMAAITKSAMRAIKLYKHVVQSVEKFILKCKPEYKVPGLYV 65
            ||.|..||:||..|.|.:||||||||..|||:|::|||.||||||||||||.|||||||||||||
Mouse     1 MEAVKTFNSELYSLNDYKPPISKAKMTQITKAAIKAIKFYKHVVQSVEKFIQKCKPEYKVPGLYV 65

  Fly    66 IDSIVRQSRHQYGMDKDLFAPRFQRNLTETFANLFRCAPEDKSRIIRVLNLWQKNNVFKSEVIQP 130
            |||||||||||:|.:||:|||||..|:..||.||:||..:|||:|:|||||||||||||||:|||
Mouse    66 IDSIVRQSRHQFGQEKDVFAPRFSNNIISTFQNLYRCPGDDKSKIVRVLNLWQKNNVFKSEIIQP 130

  Fly   131 IFDLA---------------------DPNHPIYHQMPPVGGSGGQGGGVGPGPSSSGALSLADIS 174
            :.|:|                     .|..|:....|.....|.....|....::....::|.|.
Mouse   131 LLDMAAGIPPPVVTPVLASTTAAMSNTPGTPVTPVTPANVVQGLPDPWVSQIANTDTLAAVAQIL 195

  Fly   175 SGPNGLN-----------------------SSGMEISMNSSGGDDKMGGA----MPDLSLG---- 208
            ..|.|..                       .:|:.:.:.:.........|    :..|..|
Mouse   196 QSPQGQQLQQLIQTLQIQQQKPQPSILQALDAGLVVQLQALTAQLTAAAAAANTLTPLDQGVSFN 260

  Fly   209 ---HEKFGGGSSSSKRHYSEQHYSKRQSVVSCSSKTSKSHHHKREYVKSSHDIDYQVREIIEEED 270
               .::|..|..|   .:||:  ||::......|..|:|         .::.|.:|:.|.::::
Mouse   261 KKLMDRFDFGEDS---EHSEE--SKKEMPTPQLSHVSES---------VNNSIFHQIAEQLQQQ- 310

  Fly   271 EGLQMLMADDHHCMGDDSPPTSSNLLDEKKIKQLLNNPNVLRQLHTLQNFQNLKPQEENQKHRYQ 335
                                   ||  |:..:|||..          |..|.:.|| ::|:..:.
Mouse   311 -----------------------NL--EQLRQQLLEQ----------QQPQKVTPQ-DSQEGTFG 339

  Fly   336 DE--------ALQQHFQNVMKGNAGMPPGMGMGMNMNDSMDLNKDVEFISEQQTI---EVINLDG 389
            .|        :.||||         :.|    ..|::||:|:.:....|.|.|.:   |:..
Mouse   340 SEHSASPSQGSSQQHF---------LEP----EANLDDSIDIQQQDMDIDEGQDVVEEEIFE--- 388

  Fly   390 GDSRSPTPDRDRY---KRSRRNSRSRTRSPRGRGAGGGTGNDRRRRGTRSRSRSRSPRSSRRRGS 451
                   |:..:.   .|||.:||||:||||.|.:...:|:.:|:...||||.|   |..:|:.|
Mouse   389 -------PEAKKVAVRSRSRTHSRSRSRSPRKRRSRSRSGSRKRKHRKRSRSHS---REKKRKAS 443

  Fly   452 RDRDRMDRSNRDKERDREHERERRKKGLPDIKKEHLSVCSTTLWVGHLSKLVYQEELSDTFGEYG 516
                   ||...:.|.||.|:||:|||||.::.:.|||||||||||.:.|...|::|::.|.|:|
Mouse   444 -------RSYSSERRAREREKERQKKGLPPVRSKTLSVCSTTLWVGQVDKKATQQDLTNLFEEFG 501

  Fly   517 DIVSIDQIVPRGCAFIVMNRRQDAHKAMQALK--NHKLQGRAITISWAAGKGVKSKEWKDYWDLE 579
            .|.||:.|.|||||::.|..|||:.:|:|.|.  ::|:..:.|.|:||..||||: |:|.:||::
Mouse   502 QIESINMIPPRGCAYVCMVHRQDSFRALQKLSSGSYKIGSKVIKIAWALNKGVKT-EYKQFWDVD 565

  Fly   580 LGVTYIPWSKLSSDTDFDALEEGGMFDEDTMPIQ---------MKQKINQAKNAAKEHKGASIAE 635
            ||||||||.|:..| |.|...||||.|::|:..:         :|:.:..|::.|...|.:.:..
Mouse   566 LGVTYIPWEKVKVD-DLDGFAEGGMIDQETVNAEWETVKASEPVKEPVQTAQSPAPVEKESVVTT 629

  Fly   636 AAGAPSVGVPPPNLIFGIDTTQP-------PPVGPVGPVGPPPG--PGAPPPGLMGMVRGQF-PM 690
            .|..    .|||..:..|.....       ||..||....||||  |..|||    .:|..| |.
Mouse   630 QAEV----FPPPVAMLQIPVAPAVPAVSLVPPAFPVSMPVPPPGFNPIPPPP----FLRASFNPS 686

  Fly   691 APPMGINMPPPIMMPPTNMPPPM---MMPTTNMPPPMMMPP----------TMMPPGFPGIGGPP 742
            .||.|. ||||:  ||..:|||.   ::||:.:.||:.|.|          .::|.|  .:.|..
Mouse   687 QPPPGF-MPPPV--PPPVVPPPAIPPVVPTSLVQPPLSMTPEAVKDVGFGSLVLPSG--SVAGSL 746

  Fly   743 HPMALPPGAPFPPPGAVPP----------PIPSGGQISNSGNVSDDQMDIEMDLEDAPPLPPQQQ 797
            .|..||.|..|.||....|          .||||                    |:..|:
Mouse   747 APSTLPAGNVFNPPSKAEPEEKVPHLIEHQIPSG--------------------ENTRPV----- 786

  Fly   798 ANFNPSPSNVDLSPAAMANEMFQQRDRERDRDNRDRSRGPGNSRWGG-----RDDVVEAAERWRA 857
                 .||::..|.|.:|                   :.||.|...|     |.:|...:|.
Mouse   787 -----IPSDIPSSAAMLA-------------------QPPGASSTSGILCVQRPNVSSNSEI--- 824

  Fly   858 ENGGGGGGPGSGLGPNAAFNEARARLNLNPIEHGMPRPDFMDFDNRGGPGGPRGMGPRGNHNGGG 922
                      .|:.|....|.| |.:...|       |:.::      ..|...:.|....:|.|
Mouse   825 ----------LGVRPANVSNSA-AIMGAQP-------PNILN------NSGILAIQPPNVSSGSG 865

  Fly   923 PGGDFFPPNMNHN---------RFNQPTSLM-------QMRIPPPASFNQRMGGPA--------G 963
            ..| ..|||:.:|         ....|..|:       ...:||.|...|||  ||        |
Mouse   866 LLG-VLPPNLPNNSGLVGLQPPNVTSPAGLLGTQPPIGPQNLPPLAIPAQRM--PALPMLDIRPG 927

  Fly   964 NGGNGVGPMFMRNQGGGPGGAG--------------PSGGGPGGAGTGGGGPGGRQQGPG--FFN 1012
            ......||.|...|.|.|...|              |.|..|                ||  |..
Mouse   928 LIAQAPGPRFPLLQPGIPPQRGIPPPSVLDAALHPPPRGPFP----------------PGDLFSQ 976

  Fly  1013 PRNPF---------------------NDNQRGRGG--------QSGGG--------VRGVGG--- 1037
            |..||                     |||.:..|.        ::..|        ||.|.|
Mouse   977 PERPFLAPGRPSIDNVPNPDKRIPLGNDNIQQEGDRDYRFPPIETREGITRPPQVDVRDVVGRRL 1041

  Fly  1038 GGGGGPG----------GR-----------------GR-----WSDDEDEGGNNFKRR------- 1063
            ....|||          ||                 ||     :..::..|..:|..|
Mouse  1042 DPREGPGRPPLDARDHFGRPPVDMRENLVRPSLDHLGRRDHFGFPPEKPWGPRDFDEREHRVLPV 1106

  Fly  1064 -GGPGGPGGNRFRGERGGEMMDDRRGNNSRG-GRGGPR--EDRERPGFGNRRGSRDDSNRHSISS 1124
             |||.|....|.|...|....|.|.|..:|| |:...|  :||.||  ..|:..|||.: .....
Mouse  1107 FGGPKGLHEERGRFRAGNYRFDPRSGPWNRGFGQEVHRDFDDRRRP--WERQRDRDDRD-FDFCR 1168

  Fly  1125 TDEGNKAASETEPKPKNVETELGSTNTGAPAAATRVDTEEDWDQELQDYEARMEAQKP------- 1182
            ...||:...:.            ..||..|....||          .||.....:|:.
Mouse  1169 EINGNRLGRDR------------IQNTWVPPPHARV----------FDYFEGATSQRKGDNVPQV 1211

  Fly  1183 -GERASQSANSPP---------QEKLPA----ENENFAKPADVTGDPLVAKSQTE 1223
             ||...:.|..||         .|||.:    :.|.....|.|..:.:|..::||
Mouse  1212 NGENTERHAQPPPLPVQKDPELYEKLASSGDVDKEESGTVAGVESEAVVESTETE 1266

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4266	NP_001097394.1	CID	7..125	CDD:239621	88/117 (75%)
		RRM	<488..>593	CDD:223796	54/106 (51%)
		RRM_SCAF4_SCAF8	490..566	CDD:240673	35/77 (45%)
		DUF2413	1147..>1254	CDD:287302	22/98 (22%)
		Herpes_DNAp_acc	<1206..1304	CDD:282746	5/18 (28%)
Scaf8	NP_598884.2	CID_SCAF8	5..135	CDD:340801	95/129 (74%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	270..290		6/24 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	322..355		8/43 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	385..469		37/103 (36%)
		RRM_SCAF8	475..553	CDD:240908	35/77 (45%)
		PHA03247	<611..1079	CDD:223021	127/575 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	776..807		14/79 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	984..1012		4/27 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1040..1065		5/24 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1199..1268		15/68 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167839246
Domainoid	1	1.000	131	1.000	Domainoid score	I5131
eggNOG	1	0.900	-	-		E1_KOG0132
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	456	1.000	Inparanoid score	I1572
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002970
OrthoInspector	1	1.000	-	-		otm42716
orthoMCL	1	0.900	-	-		OOG6_105962
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1302
SonicParanoid	1	1.000	-	-		X1964
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.770