DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9993 and CG18586

DIOPT Version :9

Sequence 1:	NP_611518.1	Gene:	CG9993 / 37358	FlyBaseID:	FBgn0034553	Length:	543	Species:	Drosophila melanogaster
Sequence 2:	NP_647993.2	Gene:	CG18586 / 38659	FlyBaseID:	FBgn0035642	Length:	545	Species:	Drosophila melanogaster

Alignment Length:	557	Identity:	164/557 - (29%)
Similarity:	265/557 - (47%)	Gaps:	61/557 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ASTKYDSFEKIWSGPKDKEYYGPDMTLGEVALIILRLYSDKV------MQVYDPTGEELTGSQLL 60
            |...||...|||||.:....:.|::::||:      ::.|.|      .|:.......||...|.
  Fly    13 AMCTYDDKLKIWSGREAPSLFSPNLSIGEI------IFGDMVNNPKLIAQISITEDIVLTREDLH 71

  Fly    61 EQSRRLAHAFQRLKLQRGDVVGISAKNTTYLTEVVIAALLNGTPINPLHPDFDAETTAYMFEITK 125
            ..:.|:|...:.:.|.:.|:||:..::||:.:.|..|...||||::.||..::....|.:|.|||
  Fly    72 MNAMRVASYMRNMGLGQTDIVGVMGRHTTHQSAVAYACFFNGTPLHALHNAYEEACIAKLFGITK 136

  Fly   126 PKVIFCDLDNYQTLSAVKSSLK-FKTEIILLTG------------TLPGVRNIQDL-LADGCTGY 176
            |::||||.|.|:   .|||:.| .:..|:.:..            |.|.::|.|.| |.||.
  Fly   137 PRLIFCDGDEYE---KVKSATKDLQVTIVTMRNHPRGSVRIQDVLTTPVMQNFQPLRLKDGI--- 195

  Fly   177 DEKTLFACPHLCGDDTAFIITSSGVTGLPKGVT--RSHRSLLNSAKIPQLFTSDTVLFCFSPLYW 239
                         |.|..|::|||.:|.||.||  .||:.:::...|    .:..:.:..|.|.|
  Fly   196 -------------DHTLAILSSSGTSGFPKAVTISNSHKIIVDYMAI----NNSNIQYTSSTLDW 243

  Fly   240 ISCIFTLLASLVNGCRRIITNRPFSVAYFADLVERHQVSFVLTVPHHMALLAKSPERQELAAKMQ 304
            .|.:...:.|.|.....||.:..|....|...:.::::|.||....::|:.|..||.:  :|.:.
  Fly   244 CSGLSMAITSGVFSTTSIIADCDFDPGLFCRAIGKYRISMVLLSSSYLAIFANCPEFE--SADLS 306

  Fly   305 CVQSFVCSGSKVPMGIWRQLYELLGANRFAVLYGLTE---TGGISKNVGGPLGSEGRLLRNVQVR 366
            .:...:..||...:.:.|::...|..:.....|||||   .|.::.|......|.||.:|.::::
  Fly   307 SLNYVIFGGSSCSLEVQRKVRSRLSHDCLNFCYGLTELNSAGSVNLNFDEKPNSVGRAIRGIKIK 371

  Fly   367 VVDPHGQSLGPNQTGQILVRLNLRWGGYYHNPQETQVTVTPDGKWLLTGDHGYFDDEGCLHFQSR 431
            |:|..|::..||..|:|....:.:|.|||.||.||: .:.....|:.|||.||.|.:|.|....|
  Fly   372 VIDEQGEAQEPNVVGEICFHNSQKWAGYYKNPDETR-QIQDSENWIHTGDLGYVDKDGYLFVIDR 435

  Fly   432 DTDVFKYNHFPIYPKQIEDVILHLPGVHEVAVFGIPDEVSTNLTACAVVRNEDELGAQLTEADVK 496
            ..|:.||.:...||.:||:||..:|.|.|..||||.|.|:.:..|.::|:..   |.||...||.
  Fly   436 LKDMLKYQNIMYYPSEIENVIAEMPNVLEACVFGIWDPVNGDEAAASLVKKP---GTQLEAQDVV 497

  Fly   497 GVVAQHLSDAF-HIRGGVFFVDNLPKTQNSKVQRRKI 532
            ..|.:.::..| .:.||...||.:.::.|.|..|..:
  Fly   498 EYVRKRITAKFKQLNGGALIVDQIVRSGNRKTNRSAV 534

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9993	NP_611518.1	CaiC	21..532	CDD:223395	156/536 (29%)
CG9993	NP_611518.1	AFD_class_I	45..528	CDD:302604	150/502 (30%)
CG18586	NP_647993.2	CaiC	35..541	CDD:223395	156/535 (29%)
CG18586	NP_647993.2	AFD_class_I	55..530	CDD:302604	150/503 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45471336
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0318
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG26958
OrthoDB	1	1.010	-	-		D24284at7147
OrthoFinder	1	1.000	-	-		FOG0004528
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24096
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X778
	8	7.860