DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fem-1 and fem1b

DIOPT Version :9

Sequence 1:	NP_611508.1	Gene:	Fem-1 / 37344	FlyBaseID:	FBgn0034542	Length:	702	Species:	Drosophila melanogaster
Sequence 2:	NP_001238770.2	Gene:	fem1b / 100488880	XenbaseID:	XB-GENE-999856	Length:	629	Species:	Xenopus tropicalis

Alignment Length:	644	Identity:	259/644 - (40%)
Similarity:	382/644 - (59%)	Gaps:	33/644 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    61 LHLAARSGQMLSFVEILNSVSCRAVQTHLVNTNFDQPDGQSLTPLTMAAMMGNVKFVKTLLSHYD 125
            ::.||..|::|:...:|.:.:...::|.|  :...|..||..|||.:||..|:.|.|:.||.||.
Frog    10 VYKAAAEGRVLTLAALLLNRTEPEIRTLL--STVTQHGGQRSTPLIIAARNGHSKVVRLLLEHYK 72

  Fly   126 VDLDRECNVIYDGMVVYGATALWVAAGMGHLQIVKMLVQAGAAINHNTKAQSSPLRAACYEGRLD 190
            ||:.:...|.:||.::.||||||.|||.||.::||:||..||.:||.|...|:||||||::||||
Frog    73 VDVQQTGTVRFDGYIIDGATALWCAAGAGHYEVVKLLVSHGANVNHTTVTNSTPLRAACFDGRLD 137

  Fly   191 IVEFLIDNGADVNATNLFNNNTLMIAAYKGHHLVVKTLLQNGSRANDQALCGATALHYAAESGHL 255
            ||.||::|.|:::..|.::|..|||||||||..||:.||:..:..|.:|.|||||||:|||:|||
Frog   138 IVRFLVENNANISIANKYDNTCLMIAAYKGHTDVVRYLLEQHADPNARAHCGATALHFAAEAGHL 202

  Fly   256 DVVVALLDHGATLKKNELGITPALQAAERLHEDVLEAFIERPELMSLEEQITALELLGATYANDK 320
            |:|..|:...|.:..|..|:||...|||....:|:|..:...: ...:.:|.|||||||::|||:
Frog   203 DIVRELVKWKAAMVVNGHGMTPLKVAAESCKAEVVELLLAHSD-CDTKSRIEALELLGASFANDR 266

  Fly   321 IKYDVNKAYGYLLRAMQLRYSNPRGVIRKRVQPTVPAYDNWLETENLPELYAIKLNHHSIHMESL 385
            ..|::.|.|.||..||..|:.:|..::.|.|.|.:.||....|.....||.||..|..::|||.|
Frog   267 ENYNLTKTYQYLYLAMLERFRDPSNILHKEVLPPIEAYGMRTECRTPQELGAIIHNTDALHMEGL 331

  Fly   386 AIRERILGRNNPELPQAIIYRGAVMADQGRFYQCQVLWNYAIDLRMRNNVSVDRDLLRFAQLFAQ 450
            .:||||||.:|.::...|||||||.||..:|.||..||.:|:.||.:.|.:..:|||||||:|:|
Frog   332 IVRERILGSDNIDVSHPIIYRGAVYADNMQFEQCIKLWLHALQLRQKGNRNTHKDLLRFAQVFSQ 396

  Fly   451 ILRVEN--HNLTLDHVLPVLAKCQ-QEIENNKFKIKE-AKPNACPSLWQDQNNQ-NCITALYLIK 510
            ::.:..  .:..::|||    :|. .|||....:::. .:|:|..:|   :|:: |..|.|||:.
Frog   397 MIHLNEPVKSWDVEHVL----ECSVLEIERGISRVQNPQEPDAHSAL---ENHECNLYTFLYLVC 454

  Fly   511 IVTHLARRKKDQNIDEEHIQQLFLVVRKFIQNDTRLQDGQTLLHIAVNGVMPVDEFYTNEMCRFP 575
            |.|.....:::|....:.|.:|       :..|.|.:||.||||:||:...|||:|:||::|.||
Frog   455 ISTKTRCSEEEQPRINKQIYRL-------VHLDPRTRDGCTLLHLAVDSGTPVDDFHTNDVCSFP 512

  Fly   576 CYATALVLVHCGASVVAVDSDRNTPLHILVTKVNTTQDRQAEMARILELFVEAGAHLDAVNAAGQ 640
            ....|.:|:.|||:|.|||...|:|||::|.......|.....|.|:.| ||||||.|..|...:
Frog   513 SAPVAKLLIDCGANVNAVDQMGNSPLHVIVQYNRPISDFLTLHAIIISL-VEAGAHPDMTNKEKK 576

  Fly   641 T----AATACKLPILANRLHAHQNAHTSLKCLAARSIATNRLNFKGLIPTQLEAFIQMH 695
            |    :.|.....:|..::      ..||||||||::..:.:.::..||..||.|::.|
Frog   577 TPLDRSTTGVSEILLKTQM------KLSLKCLAARAVRLHNIKYQNQIPRTLEEFVEFH 629

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fem-1	NP_611508.1	ANK	61..196	CDD:238125	61/134 (46%)
		ANK repeat	103..129	CDD:293786	14/25 (56%)
		Ank_2	105..206	CDD:289560	52/100 (52%)
		ANK	142..262	CDD:238125	69/119 (58%)
		ANK repeat	142..173	CDD:293786	19/30 (63%)
		ANK repeat	178..206	CDD:293786	16/27 (59%)
		Ank_2	180..266	CDD:289560	48/85 (56%)
		ANK repeat	208..239	CDD:293786	15/30 (50%)
		ANK repeat	241..266	CDD:293786	16/24 (67%)
		Ank_4	244..294	CDD:290365	23/49 (47%)
		ANK	548..685	CDD:238125	54/140 (39%)
		ANK repeat	548..594	CDD:293786	24/45 (53%)
		ANK repeat	596..636	CDD:293786	16/39 (41%)
fem1b	NP_001238770.2	Ank_2	13..119	CDD:403870	45/107 (42%)
		ANK repeat	50..87	CDD:293786	17/36 (47%)
		ANK repeat	89..120	CDD:293786	19/30 (63%)
		Ank_2	94..185	CDD:403870	49/90 (54%)
		ANK repeat	122..153	CDD:293786	17/30 (57%)
		ANK repeat	155..185	CDD:293786	15/29 (52%)
		Ank_2	160..243	CDD:403870	41/82 (50%)
		ANK repeat	188..213	CDD:293786	16/24 (67%)
		Ank_2	380..>589	CDD:423045	78/223 (35%)
		PHA03095	478..>580	CDD:222980	46/102 (45%)
		ANK repeat	485..531	CDD:293786	24/45 (53%)
		ANK repeat	533..572	CDD:293786	16/39 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	141	1.000	Domainoid score	I4688
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H7714
Inparanoid	1	1.050	423	1.000	Inparanoid score	I1743
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D133963at33208
OrthoFinder	1	1.000	-	-		FOG0008196
OrthoInspector	1	1.000	-	-		oto105361
Panther	1	1.100	-	-	LDO	PTHR24173
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4569
SonicParanoid	1	1.000	-	-		X856
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	9.190