DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment 18w and Slitrk5

DIOPT Version :9

Sequence 1:	NP_476814.1	Gene:	18w / 37277	FlyBaseID:	FBgn0004364	Length:	1385	Species:	Drosophila melanogaster
Sequence 2:	NP_001100754.1	Gene:	Slitrk5 / 306152	RGDID:	1310957	Length:	958	Species:	Rattus norvegicus

Alignment Length:	1089	Identity:	223/1089 - (20%)
Similarity:	354/1089 - (32%)	Gaps:	396/1089 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   338 LNLSNNALTRIGSKTFKELYFLQILDMRNNSIGHIEEGAFLPLYNLHTLNLAENRLHTLDNRIFN 402
            |.||.|.|.|:....|.......||.:.:|.|..||.|||..|..|..|:|..|:|..|.:..|.
  Rat    86 LLLSGNLLNRLYPNEFVNYTGASILHLGSNVIQDIETGAFHGLRGLRRLHLNNNKLELLRDDTFL 150

  Fly   403 GLYVLTKLTLNNNLVSIVESQAFRNCSDLKELDLSSNQLTEVPEAVQDLSMLKTLDLGENQISEF 467
            ||..|..|.::.|.:|::|                       |.|...|.||:.|.|.:|.:|..
  Rat   151 GLENLEYLQVDYNYISVIE-----------------------PNAFGKLHMLQVLILNDNLLSGL 192

  Fly   468 KNNTFRNLNQLTGLRLIDNRIGNIT-VGMFQDLPRLSVLNLAKNRIQSIERGAFDKNTEIEAIRL 531
            .||.||.: .||.|.|..||:..:. ||:.|.:.::..|.|.:|          ..|...|.|.|
  Rat   193 PNNLFRFV-PLTHLDLRGNRLKLLPYVGLLQHMDKVVELQLEEN----------PWNCSCELISL 246

  Fly   532 DKNFLTDINGIFATLASLLWL-NLSENHLVWFDYAFIPSNLKWLDIHGNYIEALGNY-------- 587
            ..                 || ::|.:.||.......|..|     ||..::.:...
  Rat   247 KD-----------------WLDSISYSALVGDVVCETPFRL-----HGRDLDEVSKQELCPRKLI 289

  Fly   588 --YKLQEEIRVTTLDASHNRITEIGAMSVPNSIELLFINNNIIGQIQANTFVDKTRLARVDLYAN 650
              |:::.:..::|....|.....:.:::..:|
  Rat   290 SDYEMRPQTPLSTTGYLHTTPASVNSVATSSS--------------------------------- 321

  Fly   651 VLSKISLNALRVAPVSAEKPVPEFYLGGNPFECDCSMEWLQRINNLTTRQHPHVVDLGNIECLMP 715
                    |:...|:...|                           .||| |:          .|
  Rat   322 --------AVYKPPLKPPK---------------------------GTRQ-PN----------KP 340

  Fly   716 HSRSAPLRPLASLSASDF--VCKYESHCPPTCHCCEYEQCECEVICPGNCSC---FHDATWATNI 775
            ..|....:|...|..|::  ...|::..|            ..:.||..|:|   ..|.....|.
  Rat   341 RVRPTSRQPSKDLGYSNYGPSIAYQTKSP------------VPLECPTACTCNLQISDLGLNVNC 393

  Fly   776 VDCGRQDLAALPNRIPQDVSDLYLDGNNMPELEVGHLTGRRNLRALYLNASNLMTLQNGSLAQLV 840
            .:...:.:|.|..: |.:...:||..|.:..:..........|..|:|..:.:..:|:.:...|.
  Rat   394 QERKIESIAELQPK-PYNPKKMYLTENYITVVRRTDFLEATGLDLLHLGNNRISMIQDRAFGDLG 457

  Fly   841 NLRVLHLENNKLTALEGTEFRSLGLLRELYLHNNMLTHISNATFEPLVSLEVLRLDNNRLSSLPH 905
            |||.|:|..|::..|....|..|..|:.|:|..|::..|.:.||:|:.:|::|.|:||:|.::|.
  Rat   458 NLRRLYLNGNRIERLSPELFYGLQSLQYLFLQYNLIREIQSGTFDPVPNLQLLFLNNNQLQAMPS 522

  Fly   906 LQYRHSLQGLTLGR------------------------------NAWSCRCQQLRELAQFVSDNA 940
            ..:    .||||.|                              |.|.|.|:.:...........
  Rat   523 GVF----SGLTLLRLNLRSNSFTSLPVSGVLDQLTSLIQIDLHDNPWDCTCEVVGMKLWIEQLKV 583

  Fly   941 MVVRDAHDIYC---------LDAGIKRELELIGNLANGPDCSDLLDA----------SASNISSS 986
            .|:.|  ::.|         ....||.||..       ||.||::.:          |.:|.:::
  Rat   584 GVLVD--EVICKAPKKFAETYMRSIKSELLC-------PDYSDVVVSTPTPSSIQLPSRTNAAAT 639

  Fly   987 QDL--------------AGGYRLPLLAAVLVLIFLVVVLIIVFVFR------------------- 1018
            ..:              .|...:||  :||:|..|:|.::.|||..
  Rat   640 PAVKLNSTGTPAGLGAGTGASSVPL--SVLILSLLLVFIMSVFVAAGLFVLVMKRRKKNQSDHTS 702

  Fly  1019 ------ESVRMWLFAHYG---------------------VRVCEPRFEDAGKLYDAI---ILH-- 1051
                  .|..| .::.||                     .:|..|    ||.:|:.|   :.|
  Rat   703 TNNSDVSSFNM-QYSVYGGGGGGGGGHPHAHVHHRGSALPKVKTP----AGHVYEYIPHPLGHMC 762

  Fly  1052 -----------SEKDYE-----FVCRNIAAELEHGRPPFRLCIQQRDLPPQASHLQLVEGARASR 1100
                       |.:||:     .|..:....|:..:||.....||:. |||   |||..|..
  Rat   763 KNPIYRSREGNSVEDYKDLHELKVTYSSNHHLQQQQPPPPQQPQQQP-PPQ---LQLQPGEE--- 820

  Fly  1101 KIILVLTRNLLATEWNRIEFRNAFHESLRGLAQKLVIIEETSVSAEAEDVAELSPYLKSVPSNRL 1165
                              |.|.:.|  ||..|..:..||      ..||:  |||         :
  Rat   821 ------------------ERRESHH--LRSPAYSVSTIE------PREDL--LSP---------V 848

  Fly  1166 LTCDRYFWEKLRYAIPIELSPRGNNYTLDHHERFKQPVSPGMIFRQAPPPPAYYCTEEMEANYSS 1230
            ...||::...|........:|.|:  :|..:.:|  |.||                        :
  Rat   849 QDADRFYRGILEPDKHCSTTPAGS--SLPEYPKF--PCSP------------------------A 885

  Fly  1231 ATTATPSPRPTRP-------GGAARIVDSMPMPMRPPSEHIYHSIESEY 1272
            |.|.:|:....||       .|.:|:.:  |:...||.........:||
  Rat   886 AYTFSPNYDLRRPHQYLHPGAGESRLRE--PVLYSPPGAVFVEPNRNEY 932

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
18w	NP_476814.1	leucine-rich repeat	66..91	CDD:275380
		leucine-rich repeat	92..115	CDD:275380
		LRR_8	115..181	CDD:290566
		leucine-rich repeat	116..146	CDD:275380
		leucine-rich repeat	147..170	CDD:275380
		leucine-rich repeat	171..201	CDD:275380
		LRR_RI	210..464	CDD:238064	39/125 (31%)
		leucine-rich repeat	212..236	CDD:275380
		LRR_8	235..295	CDD:290566
		leucine-rich repeat	237..260	CDD:275380
		leucine-rich repeat	261..284	CDD:275380
		LRR_8	283..345	CDD:290566	4/6 (67%)
		leucine-rich repeat	285..308	CDD:275380
		leucine-rich repeat	309..334	CDD:275380
		LRR_8	334..393	CDD:290566	21/54 (39%)
		leucine-rich repeat	335..358	CDD:275380	7/19 (37%)
		leucine-rich repeat	359..382	CDD:275380	10/22 (45%)
		LRR_8	382..441	CDD:290566	14/58 (24%)
		leucine-rich repeat	383..406	CDD:275380	9/22 (41%)
		leucine-rich repeat	407..430	CDD:275380	5/22 (23%)
		LRR_8	431..488	CDD:290566	18/56 (32%)
		leucine-rich repeat	431..451	CDD:275380	2/19 (11%)
		leucine-rich repeat	454..477	CDD:275380	9/22 (41%)
		LRR_8	477..559	CDD:290566	19/83 (23%)
		leucine-rich repeat	478..499	CDD:275380	9/21 (43%)
		leucine-rich repeat	502..525	CDD:275380	4/22 (18%)
		leucine-rich repeat	526..548	CDD:275380	3/21 (14%)
		leucine-rich repeat	590..617	CDD:275380	2/26 (8%)
		leucine-rich repeat	618..641	CDD:275380	0/22 (0%)
		leucine-rich repeat	642..689	CDD:275380	3/46 (7%)
		LRRCT	679..736	CDD:214507	9/58 (16%)
		leucine-rich repeat	775..796	CDD:275380	3/20 (15%)
		LRR_8	797..852	CDD:290566	14/54 (26%)
		leucine-rich repeat	797..817	CDD:275380	3/19 (16%)
		leucine-rich repeat	818..841	CDD:275380	5/22 (23%)
		LRR_8	841..900	CDD:290566	22/58 (38%)
		leucine-rich repeat	842..865	CDD:275380	8/22 (36%)
		LRR_4	866..907	CDD:289563	15/40 (38%)
		leucine-rich repeat	866..889	CDD:275380	8/22 (36%)
		leucine-rich repeat	890..911	CDD:275380	7/20 (35%)
		TIR	1045..1183	CDD:214587	35/158 (22%)
Slitrk5	NP_001100754.1	leucine-rich repeat	62..79	CDD:275380
		leucine-rich repeat	83..106	CDD:275380	7/19 (37%)
		LRR_8	84..141	CDD:290566	21/54 (39%)
		leucine-rich repeat	107..130	CDD:275380	10/22 (45%)
		LRR_8	129..189	CDD:290566	22/82 (27%)
		leucine-rich repeat	131..154	CDD:275380	9/22 (41%)
		leucine-rich repeat	155..178	CDD:275380	8/45 (18%)
		LRR_8	179..236	CDD:290566	21/67 (31%)
		leucine-rich repeat	179..200	CDD:275380	9/20 (45%)
		leucine-rich repeat	202..226	CDD:275380	9/23 (39%)
		LRRCT	235..>273	CDD:214507	13/69 (19%)
		LRR_8	433..493	CDD:290566	18/59 (31%)
		LRR_4	433..474	CDD:289563	12/40 (30%)
		leucine-rich repeat	435..458	CDD:275380	5/22 (23%)
		LRR_4	458..498	CDD:289563	14/39 (36%)
		leucine-rich repeat	459..482	CDD:275380	8/22 (36%)
		leucine-rich repeat	483..528	CDD:275380	15/48 (31%)
		leucine-rich repeat	530..554	CDD:275380	2/23 (9%)
		TPKR_C2	563..>599	CDD:301599	7/37 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	182	1.000	Inparanoid score	I3875
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050