DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment isopeptidase-T-3 and ubac1

DIOPT Version :9

Sequence 1:	NP_001261098.1	Gene:	isopeptidase-T-3 / 37261	FlyBaseID:	FBgn0028372	Length:	561	Species:	Drosophila melanogaster
Sequence 2:	XP_021331997.1	Gene:	ubac1 / 795038	ZFINID:	ZDB-GENE-030131-9372	Length:	416	Species:	Danio rerio

Alignment Length:	344	Identity:	98/344 - (28%)
Similarity:	166/344 - (48%)	Gaps:	40/344 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   228 LNEGDTLAQLKVRNNETFIL--------SPRRNTLPQTVSRIREVPGPNEQLVESATRYVPVNCN 284
            |.|..|:::..:::.:..||        .|:...:.....:.::...|::..:..||.
Zfish    72 LTESKTVSEENLKDKDCLILLKKRPPPAPPKMTDISSEEKKKQDNKAPDKDAILKATA------- 129

  Fly   285 QLPTIDINEIFQQSNI---QYDVRKVLISLAQASAAVIGAGPYAPRLI----AMLKQRLINRRNQ 342
            .|.|.:.:....|.||   |.::||:|:||.:.:..::...|.|..|.    |||.:...:|.::
Zfish   130 SLSTRNTDRTVTQHNIRDFQTELRKILVSLIEVAQKLLALNPDAVELFKKANAMLDEDEEDRVDE 194

  Fly   343 QADTLQCLVDMGFKRELAAFALKAHNGIYSTTMEWLIQNQNEENPQEP-PGMNMQHSLSSISP-- 404
            .|  ||.|.:|||....|..||:.::...:..|||||::.::.....| ||.....:.::.:|
Zfish   195 TA--LQQLTEMGFPESRAVKALRLNHMSVTQAMEWLIEHVDDPMVDAPLPGQESPGAAAAAAPAP 257

  Fly   405 ---STIVTNNETIENTAALIE---------IVRIYSHRD-SPPSDEIVESLTEMGFEETAVLAAL 456
               :|.:.....:.:.|::.|         ..||...|: .|.|.:.|.:|.||||:|..|:.||
Zfish   258 GASATALAARARLISQASIDEAKQDELTEIFKRIRRKREFRPDSRQAVIALMEMGFDEKEVIDAL 322

  Fly   457 KKTGNNKASACEWLCDNRSGSVIELREGLAPDSPILKVILEMPQVQMTLSNPKTFLAFLGILENE 521
            :...|.:.:|||||..:|..|..:|.:|:..:||:.:.|||.|.||:.|:||||.|||..:|||.
Zfish   323 RVNNNQQDAACEWLLGDRKPSPEDLDKGIDTNSPLFQAILENPVVQLGLTNPKTLLAFEDMLENP 387

  Fly   522 HAIRVWRGDNDTTSVITHI 540
            .....|..|.:|..|:..|
Zfish   388 LNSTQWMNDPETGPVMLQI 406

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
isopeptidase-T-3	NP_001261098.1	UBA_like_SF	345..384	CDD:304366	14/38 (37%)
isopeptidase-T-3	NP_001261098.1	UBA2_KPC2	434..472	CDD:270489	17/37 (46%)
ubac1	XP_021331997.1	UBQ	14..90	CDD:320785	3/17 (18%)
		Peptidase_C19	<195..346	CDD:321984	45/152 (30%)
		UBA1_KPC2	195..231	CDD:270488	15/37 (41%)
		UBA2_KPC2	301..338	CDD:270489	17/36 (47%)
		STI1	364..403	CDD:128966	17/38 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	52	1.000	Domainoid score	I11494
eggNOG	1	0.900	-	-		E1_28IDF
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H9409
Inparanoid	1	1.050	123	1.000	Inparanoid score	I4714
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1163759at2759
OrthoFinder	1	1.000	-	-		FOG0006086
OrthoInspector	1	1.000	-	-		oto39632
orthoMCL	1	0.900	-	-		OOG6_108746
Panther	1	1.100	-	-	LDO	PTHR46738
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4908
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.860