Protein Alignment Rep and GDI1

DIOPT Version :10

• Sequence 1: NP_477420.1
• Gene: Rep / 37246
• FlyBaseID: FBgn0026378
• Length: 511
• Species: Drosophila melanogaster
• Sequence 2: NP_001484.1
• Gene: GDI1 / 2664
• HGNCID: 4226
• Length: 447
• Species: Homo sapiens
• Alignment Length: 499
• Identity: 128/499 - (25%)
• Similarity: 212/499 - (42%)
• Gaps: 101/499 - (20%)

  Fly     5 LPEQFDLVVIGTGFTESCIAAAGSRIGKSVLHLDSNEYYGDVWSSFS-MDALCARLDQEVEPHSA 68
            :.|::|::|:|||.||..::...|..||.|||:|.|.|||...||.: ::.|..|......|..:
Human     1 MDEEYDVIVLGTGLTECILSGIMSVNGKKVLHMDRNPYYGGESSSITPLEELYKRFQLLEGPPES 65

  Fly    69 LRNARYTWHSMEKESETDAQSWNRDSVLAKSRRFSLDLCPRILYAAGELVQLLIKSNICRYAEFR 133
            :...|               .||            :||.|:.|.|.|:||::|:.:.:.||.:|:
Human    66 MGRGR---------------DWN------------VDLIPKFLMANGQLVKMLLYTEVTRYLDFK 103

  Fly   134 AVDHVCMRHNGEIVSVPCSRSDVFNTKTLTIVEKRLLMKFL---------------------TAC 177
            .|:...:...|:|..||.:.::...:..:.:.|||...|||                     |:.
Human   104 VVEGSFVYKGGKIYKVPSTETEALASNLMGMFEKRRFRKFLVFVANFDENDPKTFEGVDPQTTSM 168

  Fly   178 ND-YGEDKCNEDSLEFRGRTFLEYLQAQRVTEKISS-CVMQAIAMCGPSTSFEEGMQRTQRFLGS 240
            .| |.:....:|.::|.|.....|    |..:.:.. |:              |.:.|.:.:..|
Human   169 RDVYRKFDLGQDVIDFTGHALALY----RTDDYLDQPCL--------------ETVNRIKLYSES 215

  Fly   241 LGRYGNTPFLFPMYGCGELPQCFCRLCAVYGGIYCLKRAVDDIALDSNSNEFLLSSAGKTLRAKN 305
            |.|||.:|:|:|:||.|||||.|.||.|:|||.|.|.:.||||.:: |.....:.|.|:..|.|.
Human   216 LARYGKSPYLYPLYGLGELPQGFARLSAIYGGTYMLNKPVDDIIME-NGKVVGVKSEGEVARCKQ 279

  Fly   306 VVSAPGYTPVSKGIELKPHISRGLFISSSPLGNEELNKGGGGVNLLRLL--DNEGGREA--FLIQ 366
            ::..|.|.|  ..:.....:.|.:.|.|.|:      |.....|..:::  .|:..|::  ::..
Human   280 LICDPSYIP--DRVRKAGQVIRIICILSHPI------KNTNDANSCQIIIPQNQVNRKSDIYVCM 336

  Fly   367 LSHYTGACPEGLYI------FHLTTPALSEDPASDLA-------IFTSQLF----DQSDAQIIFS 414
            :|:......:|.||      ...|.|....:||.:|.       :..|.|:    |..::|:..|
Human   337 ISYAHNVAAQGKYIAIASTTVETTDPEKEVEPALELLEPIDQKFVAISDLYEPIDDGCESQVFCS 401

  Fly   415 -SYFTIAAQSSKSPAAEHIYYTDPPTYELDYDAAIANARDIFGK 457
             ||.......:.....:.||.....| ..|::.......|:||:
Human   402 CSYDATTHFETTCNDIKDIYKRMAGT-AFDFENMKRKQNDVFGE 444

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rep	NP_477420.1	Rossmann-fold NAD(P)(+)-binding proteins	4..397	CDD:473865	113/425 (27%)
GDI1	NP_001484.1	GDI	1..436	CDD:395792	125/489 (26%)