Protein Alignment Rep and Chml

DIOPT Version :10

• Sequence 1: NP_477420.1
• Gene: Rep / 37246
• FlyBaseID: FBgn0026378
• Length: 511
• Species: Drosophila melanogaster
• Sequence 2: NP_067325.2
• Gene: Chml / 12663
• MGIID: 101913
• Length: 621
• Species: Mus musculus
• Alignment Length: 627
• Identity: 179/627 - (28%)
• Similarity: 296/627 - (47%)
• Gaps: 155/627 - (24%)

  Fly     1 MLDDLPEQFDLVVIGTGFTESCIAAAGSRIGKSVLHLDSNEYYGDVWSSFSMDALCARLDQEVEP 65
            |.:.||.:||:|:||||..||.:|||.||.|:.|||:||..|||..|:|||...|.:.|....:.
Mouse     1 MAEKLPTEFDVVIIGTGLPESILAAACSRSGQRVLHVDSRSYYGGNWASFSFTGLQSWLKDYQQN 65

  Fly    66 HSALRNARYTWH----------SMEKESET-------------------DAQSWNRDS------- 94
            |.:......||.          |:.|:.||                   |.::..|.|
Mouse    66 HDSEEGVTATWQDLIHETEEAISLRKKDETIQHTEVFCYASQDVEDSVQDTETLQRSSPLEASAT 130

  Fly    95 ----------------------------------------------------------------- 94
                                                                             
Mouse   131 PADSLDSASLPKERQSAYSTSYEVPSRHTEESDRELSLPSANVEDSLEKEKYCGDKTDMHTVSGE 195

  Fly    95 -------------------------VLAKSRRFSLDLCPRILYAAGELVQLLIKSNICRYAEFRA 134
                                     ::.:||||::||..:.||:.|.|:.||||||:.|||||:.
Mouse   196 DKGEHKLVVQDSIEQPKRNRITYSQMVKESRRFNIDLVSKPLYSQGSLIDLLIKSNVSRYAEFKN 260

  Fly   135 VDHVCMRHNGEIVSVPCSRSDVFNTKTLTIVEKRLLMKFLTACNDYGEDKCNEDSLEFRGRTFLE 199
            |..:.....|::..|||||:||||:|.|::||||:||||||.|.||  ::.:::..:|:..:|.:
Mouse   261 VTRILAFWEGKVEQVPCSRADVFNSKELSMVEKRMLMKFLTFCLDY--EQHSDEYQDFKQCSFSD 323

  Fly   200 YLQAQRVTEKISSCVMQAIAMCGPST-SFEEGMQRTQRFLGSLGRYGNTPFLFPMYGCGELPQCF 263
            ||:.:::|..:...::.:|||...|: :..:|:|.|:.||..|||:|||||:||:||.||:||||
Mouse   324 YLKTKKLTPNLQHFILHSIAMTSESSCTTLDGLQATKTFLQCLGRFGNTPFIFPLYGHGEIPQCF 388

  Fly   264 CRLCAVYGGIYCLKRAVDDIALDSNSN--EFLLSSAGKTLRAKNVVSAPGYTP--VSKGIELKPH 324
            ||:|||:||:|||:..|..:.:|.:|.  :.::.:.|:.:.|...:....|.|  ....::.| .
Mouse   389 CRMCAVFGGVYCLRHKVQCLVVDKDSGRCKGIIDAFGQRISANYFIVEDSYLPKETCSNVQYK-Q 452

  Fly   325 ISRGLFISSSPLGNEELNKGGGGVNLLRLLDNEGGREAF-LIQLSHYTGACPEGLYIFHLTTPAL 388
            |||.:.|:...:...:.::   .:::|.:...|.|..:. :::|...|..|.:..|:.|||..:
Mouse   453 ISRAVLITDQSILKTDSDQ---QISILVVPPLEPGTTSVRVMELCSSTMTCMKDSYLVHLTCSS- 513

  Fly   389 SEDPASDLAIFTSQLF-DQSDAQ----------IIFSSYFTI-----AAQSSKSPAAEHIYYTDP 437
            |:....||.....||| .:::|:          ::::.||.:     .::||......::|....
Mouse   514 SKTAREDLEPVVKQLFIPEAEAEAGKDELRKPRLLWALYFNMRDSSGVSRSSYCGLPSNVYICSG 578

  Fly   438 PTYELDYDAAIANARDIFGKMFPDADFLPRAPDPEEIVVDGE 479
            |.:.|..:.|:..|..:|.::||..:|.|..|:||:|:.:.|
Mouse   579 PDWGLGSEHAVKQAETLFQEIFPSEEFCPPPPNPEDIIFEAE 620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Rep	NP_477420.1	Rossmann-fold NAD(P)(+)-binding proteins	4..397	CDD:473865	154/524 (29%)
Chml	NP_067325.2	Rossmann-fold NAD(P)(+)-binding proteins	6..528	CDD:473865	154/528 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	113..171		3/57 (5%)