DRSC/TRiP Functional Genomics Resources

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Protein Alignment CalpA and Capn6

DIOPT Version :10

Sequence 1:NP_001286613.1 Gene:CalpA / 37232 FlyBaseID:FBgn0012051 Length:843 Species:Drosophila melanogaster
Sequence 2:NP_113996.2 Gene:Capn6 / 83685 RGDID:70960 Length:641 Species:Rattus norvegicus


Alignment Length:520 Identity:187/520 - (35%)
Similarity:282/520 - (54%) Gaps:55/520 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly    81 LGPYSEV---QDYETILNSCLASGSLFEDPLFPASNESLQFSRRPDRHIEWLRPHEIAENPQFFV 142
            :||..::   |.|:.:...|:..|.||.||.|...|:||.|:|.....:.|.||.:|:::|...|
  Rat     1 MGPPLKLFKNQKYQELKQDCMKDGRLFCDPTFLPENDSLFFNRLLPGKVVWKRPQDISDDPHLIV 65

  Fly   143 EGYSRFDVQQGELGDCWLLAATANLTQESNLFFRVIP--AEQSFE----ENYAGIFHFRFWQYGK 201
            ...|...:.||.||:..:::|.:.|..:.:.:.:.||  .||.::    |.|||||.||||.:|:
  Rat    66 GNISNHQLIQGRLGNKAMISAFSCLAVQESHWTKAIPNHKEQEWDPRKPEKYAGIFRFRFWHFGE 130

  Fly   202 WVDVIIDDRLPTYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCEAMEDFTGGVSE 266
            |.:|:|||.|||.||:|::..||..||||:||||||||||.|.||||.|.:..:.:.||||.::|
  Rat   131 WTEVVIDDLLPTINGDLVFSFSTSMNEFWNALLEKAYAKLLGCYEALDGLTITDIIMDFTGTLAE 195

  Fly   267 --------WYDLKEAPGNLFTILQKAAERNSMMGCSIE-PDPNVTEAETPQGLIRGHAYSITKV- 321
                    :.||.|....||..|.|...:..::.|||| |.....|.||..||::|:.|::|.: 
  Rat   196 IIDMQKGRYTDLVEEKYKLFGELYKTFTKGGLISCSIESPSQEEQEVETDWGLLKGYTYTMTDIR 260

  Fly   322 ------CLIDIVTPNRQGKIPMIRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFDRDG 380
                  .|:::.:..   |:.|:|:|||.|.: ||:||||:.|.||:.:....:..:||....||
  Rat   261 KLRLGERLVEVFSTE---KLYMVRLRNPLGRQ-EWSGPWSEISEEWQQLTVTDRKNLGLVMSDDG 321

  Fly   381 EFWMSFQDFLNHFDRVEICNLSPDSLTEDQQNSGKRKWEMSMYEGEWT----PGVT-AGGCRNFL 440
            |||||.:||.::|.::.:|        .:..|....:.|:....|.||    |.:. :|||.|..
  Rat   322 EFWMSLEDFCHNFHKLNVC--------RNVNNPVFGRKELESVVGCWTVDDDPLMNRSGGCYNNR 378

  Fly   441 DTFWHNPQYIITLVDPDEEDEEGQCTVIVALMQKNRRSKRNMGM-ECLTIGFAIYSLNDRELENR 504
            |||..|||||.|:      .|:|. .||::|.||:.|:.|.||. :...|||.::.:.    .||
  Rat   379 DTFLQNPQYIFTV------PEDGH-KVIMSLQQKDLRTYRRMGRPDNYIIGFELFKVE----MNR 432

  Fly   505 PQGLNFFRYKSSVGRSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETQNNMEE 569
            ...|:....:...|.|. :|:||.|.....|..|:|::||:.|......||::|:|||....:.|
  Rat   433 RFRLHHLYIQERAGTST-YIDTRTVFLSKYLKKGNYVLVPTMFQHGRTSEFLLRIFSEVPVQLRE 496

  Fly   570  569
              Rat   497  496

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CalpANP_001286613.1 Peptidase_C2 104..400 CDD:459889 124/317 (39%)
Calpain_III 416..569 CDD:238132 53/158 (34%)
EFh_PEF_CalpA_B 600..843 CDD:320071
EF-hand motif 600..627 CDD:320071
EF-hand motif 717..747 CDD:320071
EF-hand motif 748..778 CDD:320071
EF-hand motif 784..812 CDD:320071
EF-hand motif 813..843 CDD:320071
Capn6NP_113996.2 CysPc 13..351 CDD:128526 130/349 (37%)
Domain III 344..495 54/162 (33%)
Calpain_III 349..497 CDD:238132 54/160 (34%)
C2_Calpain 514..639 CDD:176011
Blue background indicates that the domain is not in the aligned region.

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