DRSC/TRiP Functional Genomics Resources

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Protein Alignment CalpA and CAPN3

DIOPT Version :10

Sequence 1:NP_001286613.1 Gene:CalpA / 37232 FlyBaseID:FBgn0012051 Length:843 Species:Drosophila melanogaster
Sequence 2:NP_000061.1 Gene:CAPN3 / 825 HGNCID:1480 Length:821 Species:Homo sapiens


Alignment Length:873 Identity:340/873 - (38%)
Similarity:485/873 - (55%) Gaps:164/873 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    60 PLQSQSNSTLYYGNLGEKSSSLGPYSEV------------QDYETILNSCLASGSLFEDPLFPAS 112
            |..:||.:|...|  |..|   |.||.:            :.:|.:...||....|:.||.||..
Human    24 PHPAQSKATEAGG--GNPS---GIYSAIISRNFPIIGVKEKTFEQLHKKCLEKKVLYVDPEFPPD 83

  Fly   113 NESLQFSRRPDRHIEWLRPHEIAENPQFFVEGYSRFDVQQGELGDCWLLAATANLTQESNLFFRV 177
            ..||.:|::......|.||.||.|||:|.::|.:|.|:.||||||||.|||.|.||...:|.|||
Human    84 ETSLFYSQKFPIQFVWKRPPEICENPRFIIDGANRTDICQGELGDCWFLAAIACLTLNQHLLFRV 148

  Fly   178 IPAEQSFEENYAGIFHFRFWQYGKWVDVIIDDRLPTYNGELMYMHSTEKNEFWSALLEKAYAKLH 242
            ||.:|||.|||||||||:||:||:||||:|||.|||||.:|::..|..:||||||||||||||||
Human   149 IPHDQSFIENYAGIFHFQFWRYGEWVDVVIDDCLPTYNNQLVFTKSNHRNEFWSALLEKAYAKLH 213

  Fly   243 GSYEALKGGSTCEAMEDFTGGVSEWYDLKEAPGNLFTILQKAAERNSMMGCSIEPDPNVTEAETP 307
            |||||||||:|.||||||||||:|::::::||.:::.|::||.||.|:|||||:...|:|...:|
Human   214 GSYEALKGGNTTEAMEDFTGGVAEFFEIRDAPSDMYKIMKKAIERGSLMGCSIDDGTNMTYGTSP 278

  Fly   308 Q-------------------------------------------------GLIRGHAYSITKVCL 323
            .                                                 ||:||||||:|.   
Human   279 SGLNMGELIARMVRNMDNSLLQDSDLDPRGSDERPTRTIIPVQYETRMACGLVRGHAYSVTG--- 340

  Fly   324 IDIVTPNRQGKIPMIRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFDRDGEFWMSFQD 388
            :|.| |.:..|:.::|:||||| :.||||.|||...:|.::.:::||.:......|||||||::|
Human   341 LDEV-PFKGEKVKLVRLRNPWG-QVEWNGSWSDRWKDWSFVDKDEKARLQHQVTEDGEFWMSYED 403

  Fly   389 FLNHFDRVEICNLSPDSLTEDQQNSGKRKWEMSMYEGEWTPGVTAGGCRNFLDTFWHNPQYIITL 453
            |:.||.::|||||:.|:|..|:..:    |.:|:.||.|..|.:|||||||.||||.||||.:.|
Human   404 FIYHFTKLEICNLTADALQSDKLQT----WTVSVNEGRWVRGCSAGGCRNFPDTFWTNPQYRLKL 464

  Fly   454 V--DPDEEDEEGQCTVIVALMQKNRRSKRNMGMECLTIGFAIYSLNDRELENRPQGL--NFFRYK 514
            :  |.|.:|.|..|:.:|||||||||..|.:|....|||||||.: .:|:....|.|  :||.|.
Human   465 LEEDDDPDDSEVICSFLVALMQKNRRKDRKLGASLFTIGFAIYEV-PKEMHGNKQHLQKDFFLYN 528

  Fly   515 SSVGRSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETQNNMEENDDHVGYGGK 579
            :|..||..:||.|||..||:|||..|:|||||::|::|||||:|||||.:|..||.::.:.    
Human   529 ASKARSKTYINMREVSQRFRLPPSEYVIVPSTYEPHQEGEFILRVFSEKRNLSEEVENTIS---- 589

  Fly   580 ADTITPGFPTPKPIDPQKEGLRRLFDSIAGKDMEVDWMELKRILDHSMRDDLPKPVVFNRFSNNM 644
                     ..:|:..:|                                  .||::|.....|.
Human   590 ---------VDRPVKKKK----------------------------------TKPIIFVSDRANS 611

  Fly   645 AFETQAAGPGDDGAGACGLLSLICGPFLKGTPFEE------QLGMNDQSN----------KRLIG 693
            ..|.......::|.|             |.:|.::      |.|.:||.:          |::.|
Human   612 NKELGVDQESEEGKG-------------KTSPDKQKQSPQPQPGSSDQESEEQQQFRNIFKQIAG 663

  Fly   694 DNP---ADGGPVTANAIVD-----ETHGFSKDVCRSMVAMLDADKSGKLGFEEFETLLSEIAKWK 750
            |:.   ||......|.:|:     :||||:.:.||||:|::|.|.||||..:||..|.::|..|:
Human   664 DDMEICADELKKVLNTVVNKHKDLKTHGFTLESCRSMIALMDTDGSGKLNLQEFHHLWNKIKAWQ 728

  Fly   751 AIFKVYDVENTGRVSGFQLREALNSAGYHLNNRVLNVLGHRYGSRDGKIAFDDFIMCAVKIKTYI 815
            .|||.||.:.:|.::.:::|.|:|.||:||||::.:::..||..:...|.||.||.|.|:::...
Human   729 KIFKHYDTDQSGTINSYEMRNAVNDAGFHLNNQLYDIITMRYADKHMNIDFDSFICCFVRLEGMF 793

  Fly   816 DIFKERDTEKNETATFTLEEWIERTIYS 843
            ..|...|.:.:......:.||::.|:|:
Human   794 RAFHAFDKDGDGIIKLNVLEWLQLTMYA 821

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CalpANP_001286613.1 Peptidase_C2 104..400 CDD:459889 164/344 (48%)
Calpain_III 416..569 CDD:238132 82/156 (53%)
EFh_PEF_CalpA_B 600..843 CDD:320071 69/266 (26%)
EF-hand motif 600..627 CDD:320071 0/26 (0%)
EF-hand motif 717..747 CDD:320071 14/29 (48%)
EF-hand motif 748..778 CDD:320071 11/29 (38%)
EF-hand motif 784..812 CDD:320071 9/27 (33%)
EF-hand motif 813..843 CDD:320071 5/29 (17%)
CAPN3NP_000061.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 7..37 5/14 (36%)
Peptidase_C2 75..415 CDD:459889 164/344 (48%)
Domain III 418..586 87/172 (51%)
Calpain_III 435..574 CDD:460050 75/139 (54%)
Calpain_u2 583..653 CDD:465216 16/129 (12%)
Linker 587..649 15/121 (12%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 609..652 10/55 (18%)
Domain IV 650..821 56/170 (33%)
EFh_PEF_CAPN3 653..821 CDD:320065 56/167 (34%)
EF-hand motif 653..681 CDD:320065 6/27 (22%)
EF-hand motif 696..725 CDD:320065 14/28 (50%)
EF-hand motif 726..756 CDD:320065 11/29 (38%)
EF-hand motif 761..790 CDD:320065 9/28 (32%)
EF-hand motif 791..821 CDD:320065 5/29 (17%)

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