DRSC/TRiP Functional Genomics Resources

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Protein Alignment CalpA and Capn9

DIOPT Version :10

Sequence 1:NP_001286613.1 Gene:CalpA / 37232 FlyBaseID:FBgn0012051 Length:843 Species:Drosophila melanogaster
Sequence 2:XP_006531467.1 Gene:Capn9 / 73647 MGIID:1920897 Length:718 Species:Mus musculus


Alignment Length:792 Identity:325/792 - (41%)
Similarity:460/792 - (58%) Gaps:132/792 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    84 YSEVQDYETILNSCLASGSLFEDPLFPASNESLQFSRRPDRHIEWLRPHEIAENPQFFVEGYSRF 148
            :|..|.:|.:...||.||:||||..|||||.||.:|.||.....|.||.||.|.|:|.:.|.:|.
Mouse    23 HSSGQSFEQLRQGCLQSGTLFEDADFPASNVSLFYSERPQVPFVWKRPGEIVEKPEFILGGATRT 87

  Fly   149 DVQQGELGDCWLLAATANLTQESNLFFRVIPAEQSFEENYAGIFHFRFWQYGKWVDVIIDDRLPT 213
            |:.||||||||||||.|:||.......||:|.:|.|...|||||||:|||:.:|:||:|||||||
Mouse    88 DICQGELGDCWLLAAIASLTLNQKALTRVVPQDQGFGSGYAGIFHFQFWQHSEWLDVVIDDRLPT 152

  Fly   214 YNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCEAMEDFTGGVSEWYDLKEAPGNLF 278
            :...|:::||.:.|||||||||||||||:||||||||||..||||||||||:|.:.::|||.:.|
Mouse   153 FKDRLVFLHSADHNEFWSALLEKAYAKLNGSYEALKGGSAIEAMEDFTGGVAENFQIREAPEDFF 217

  Fly   279 TILQKAAERNSMMGCSIEP-DPNVTEAETPQGLIRGHAYSITKVCLIDIVTPNRQGKIPMIRMRN 342
            .||:||.:|.|::||||:. :.:.:||.|..|||:||||::|.   :|.|..:.| :|.:||:||
Mouse   218 EILEKALKRGSLLGCSIDTLNASESEARTSLGLIKGHAYTVTG---LDQVNFHGQ-RIKLIRVRN 278

  Fly   343 PWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFDRDGEFWMSFQDFLNHFDRVEICNLSPDSLT 407
            ||| :.||||||||||||||.:..|::..:|.|...||||||:|:||..|||:||||||:||:| 
Mouse   279 PWG-QVEWNGPWSDSSPEWRSVDLEEQKRLGHTALDDGEFWMAFKDFKIHFDKVEICNLTPDAL- 341

  Fly   408 EDQQNSGKRKWEMSMYEGEWTPGVTAGGCRNFLDTFWHNPQYIITLVDPDEEDEEGQCTVIVALM 472
               ::|...:||:::::|.|..|.|||||||||||||.|||..::|.:.| |.:|| ||.:.|||
Mouse   342 ---EDSALHRWEVTIHQGSWVRGSTAGGCRNFLDTFWTNPQIKLSLTERD-EGQEG-CTFLAALM 401

  Fly   473 QKNRRSKRNMGMECLTIGFAIYSLNDRE--LENRPQGLNFFRYKSSVGRSPHFINTREVCARFKL 535
            ||:||..:..|...||||:|||...|::  |..     :||||.:|:.||..|||.|||..||:|
Mouse   402 QKDRRRLKRFGANMLTIGYAIYQCPDKDGHLSR-----DFFRYHASLARSKTFINLREVSERFQL 461

  Fly   536 PPGHYLIVPSTFDPNEEGEFIIRVFSETQNNMEENDDHVGYGGKADTITPGFPTPKPIDPQKE-- 598
            |||.|:::||||:|::|.:|.:|:|||.:....:.|:::      |...|..|.|.|.:.:.|  
Mouse   462 PPGDYILIPSTFEPHQEADFCLRIFSEKRAVTRDLDENI------DIDLPELPKPTPQEEETEEE 520

  Fly   599 -GLRRLFDSIAGKDMEVDWMELKRILDHSMRDDLPKPVVFNRFSNNMAFETQAAGPGDDGAGACG 662
             ..|.||..:||:||||...||:.:|:..::.  ...:.|.|.|                     
Mouse   521 QQFRALFQRVAGEDMEVSAEELEYVLNAVLQK--KTALKFKRLS--------------------- 562

  Fly   663 LLSLICGPFLKGTPFEEQLGMNDQSNKRLIGDNPADGGPVTANAIVDETHGFSKDVCRSMVAMLD 727
            |||                                                     ||::::::|
Mouse   563 LLS-----------------------------------------------------CRNIISLMD 574

  Fly   728 ADKSGKLGFEEFETLLSEIAKW-KA---------------------------IFKVYDVENTGRV 764
            ...:|||.||||.....::..| ||                           :|..:||:.:|.:
Mouse   575 TSGNGKLEFEEFRVFWDKLKHWMKAAVTPGQLPAATGPWALTSPCSTPWSQDLFLQFDVDKSGTM 639

  Fly   765 SGFQLREALNSAGYHLNNRVLNVLGHRYGSRDGKIAFDDFIMCAVKIKTYIDIFKERDTEKNETA 829
            |.::||.||.:||:.|...:|.::..||...|.::.|||::.|.|:::....:|:....:..:..
Mouse   640 SSYELRTALKAAGFQLGGHLLQLIVLRYADEDLQLDFDDYLNCLVRLENASRVFQSLSVKNKDFI 704

  Fly   830 TFTLEEWIERTI 841
            ...:.|:|..|:
Mouse   705 HLNINEFISLTM 716

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CalpANP_001286613.1 Peptidase_C2 104..400 CDD:459889 171/296 (58%)
Calpain_III 416..569 CDD:238132 76/154 (49%)
EFh_PEF_CalpA_B 600..843 CDD:320071 56/270 (21%)
EF-hand motif 600..627 CDD:320071 12/26 (46%)
EF-hand motif 717..747 CDD:320071 10/29 (34%)
EF-hand motif 748..778 CDD:320071 13/57 (23%)
EF-hand motif 784..812 CDD:320071 9/27 (33%)
EF-hand motif 813..843 CDD:320071 4/29 (14%)
Capn9XP_006531467.1 Peptidase_C2 43..335 CDD:459889 171/296 (58%)
Calpain_III 347..496 CDD:238132 76/155 (49%)
EFh_PEF 523..718 CDD:355382 56/270 (21%)
EF-hand motif 523..550 CDD:320067 12/26 (46%)
EF-hand motif 565..594 CDD:320067 11/81 (14%)
EF-hand motif 595..652 CDD:320067 12/56 (21%)
EF-hand motif 659..687 CDD:320067 9/27 (33%)
EF-hand motif 689..717 CDD:320067 4/28 (14%)

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