DRSC/TRiP Functional Genomics Resources

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Protein Alignment CalpA and capn8

DIOPT Version :10

Sequence 1:NP_001286613.1 Gene:CalpA / 37232 FlyBaseID:FBgn0012051 Length:843 Species:Drosophila melanogaster
Sequence 2:XP_031757616.1 Gene:capn8 / 733929 XenbaseID:XB-GENE-920785 Length:1515 Species:Xenopus tropicalis


Alignment Length:775 Identity:323/775 - (41%)
Similarity:448/775 - (57%) Gaps:124/775 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    88 QDYETILNSCLASGSLFEDPLFPASNESLQFSR-----RPDRHIEWLRPHEIAENPQFFVEGYSR 147
            ||:|.:...|||||:||:|..|||...:|.|:.     ...:.:.|.||.||..||||.|:|.:|
 Frog    31 QDFEKLRAQCLASGTLFKDEEFPACPSALGFNELGPGSPKTQGVIWKRPSEICPNPQFIVDGATR 95

  Fly   148 FDVQQGELGDCWLLAATANLTQESNLFFRVIPAEQSFEENYAGIFHFRFWQYGKWVDVIIDDRLP 212
            .|::||.|||||||||.|:||.:::|..:|:|..|||:::|||||||||||||:||||::|||||
 Frog    96 GDIRQGALGDCWLLAAIASLTLDADLVAQVVPENQSFQKDYAGIFHFRFWQYGEWVDVVVDDRLP 160

  Fly   213 TYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCEAMEDFTGGVSEWYDLKEAPGNL 277
            |.||.|:::||.|.:||||||||||||||:||||||.||||.|..||||||::|.|:|::||.:|
 Frog   161 TKNGNLVFVHSAEGDEFWSALLEKAYAKLNGSYEALSGGSTIEGFEDFTGGIAEVYELRKAPSDL 225

  Fly   278 FTILQKAAERNSMMGCSIE-PDPNVTEAETPQGLIRGHAYSITKVCLIDIVTPNRQGKIPMIRMR 341
            |.|:|||....|::||||: .:...|||.|.:.|::|||||:|..  .:::...||.|  :||:|
 Frog   226 FQIIQKALRAESLLGCSIDITNAYDTEAITSRKLVKGHAYSVTGA--EEVLYRGRQEK--LIRVR 286

  Fly   342 NPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFDRDGEFWMSFQDFLNHFDRVEICNLSPDSL 406
            |||| |.||.|||||::|||.||..:.||.:....| ||||||:|.|||..:.|:||||||||:|
 Frog   287 NPWG-EVEWTGPWSDTAPEWNYIDPKVKAALDKQSD-DGEFWMAFSDFLREYSRLEICNLSPDTL 349

  Fly   407 TEDQQNSGKRKWEMSMYEGEWTPGVTAGGCRNFLDTFWHNPQYIITLVDPDEE----DEEGQCTV 467
            |..:|:    ||.:::|.|.|..|.|||||:|:..|||.|||:.|.|.|||.|    ::|..|||
 Frog   350 TNTEQH----KWNITLYNGSWARGSTAGGCQNYPATFWTNPQFRIKLDDPDHEHQGSNQEPCCTV 410

  Fly   468 IVALMQKNRRSKRNMGMECLTIGFAIYSLNDRELENRPQ---GLNFFRYKSSVGRSPHFINTREV 529
            ||.|||||||.|:.||.:.|:||::::.: ..:|:|...   |.:||:...:..||..:||.|||
 Frog   411 IVGLMQKNRRRKKKMGEDLLSIGYSLFKI-PNQLQNHTDDHLGRDFFQKTPTAARSDTYINVREV 474

  Fly   530 CARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETQNNMEENDDHVGYGGKADTITPGFPTPKPID 594
            ..||.||.|.||||||||:|.:.|:|.:|||||.:....|..|.|              ..||.:
 Frog   475 SNRFHLPVGDYLIVPSTFEPFKNGDFCLRVFSEKEAKSLEVGDVV--------------IAKPYE 525

  Fly   595 PQ------KEGLRRLFDSIAGKDMEVDWMELKRILDH--SMRDDLPKPVVFNRFSNNMAFETQAA 651
            |:      .:..:.:||.:||...|:|..||:.||:.  |.|.||                    
 Frog   526 PKISNKDVTDEFKNIFDKLAGDKEEIDAKELQTILNKLISKRPDL-------------------- 570

  Fly   652 GPGDDGAGACGLLSLICGPFLKGTPFEEQLGMNDQSNKRLIGDNPADGGPVTANAIVDETHGFSK 716
                                                                      .::||:.
 Frog   571 ----------------------------------------------------------RSNGFTV 577

  Fly   717 DVCRSMVAMLDADKSGKLGFEEFETLLSEIAKWKAIFKVYDVENTGRVSGFQLREALNSAGYHLN 781
            :.||.|:::.|.|.:..|...||..|..:|.|:.||:...|.:.:|.:...:||.||..||:.||
 Frog   578 NTCREMISLQDMDGTATLSLLEFRILWLKIQKYLAIYLKADSDRSGTMDAHELRAALQEAGFTLN 642

  Fly   782 NRVLNVLGHRYGSRDGKIAFDDFIMCAVKIKTYIDIFKERDTEKNETATFTLEEWIERTI 841
            |::...:..||.|.:..|.||.||.|.::::|...:|:..|..|......:|:||:..|:
 Frog   643 NKIQQSIVLRYASDELTINFDSFIACMMRLETLFKMFQMLDKSKKGVVELSLQEWLCATL 702

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CalpANP_001286613.1 Peptidase_C2 104..400 CDD:459889 166/301 (55%)
Calpain_III 416..569 CDD:238132 76/159 (48%)
EFh_PEF_CalpA_B 600..843 CDD:320071 57/244 (23%)
EF-hand motif 600..627 CDD:320071 10/28 (36%)
EF-hand motif 717..747 CDD:320071 9/29 (31%)
EF-hand motif 748..778 CDD:320071 10/29 (34%)
EF-hand motif 784..812 CDD:320071 9/27 (33%)
EF-hand motif 813..843 CDD:320071 8/29 (28%)
capn8XP_031757616.1 Peptidase_C2 47..343 CDD:459889 166/301 (55%)
Calpain_III 355..515 CDD:238132 76/164 (46%)
EFh_PEF_CAPN8 536..702 CDD:320066 56/243 (23%)
EF-hand motif 536..564 CDD:320066 10/27 (37%)
EF-hand motif 578..608 CDD:320066 9/29 (31%)
EF-hand motif 609..639 CDD:320066 10/29 (34%)
EF-hand motif 645..673 CDD:320066 9/27 (33%)
EF-hand motif 674..702 CDD:320066 7/27 (26%)
Peptidase_C2 809..1106 CDD:459889
Calpain_III 1125..1268 CDD:460050
EFh_PEF 1298..1515 CDD:355382
EF-hand motif 1298..1326 CDD:320054
EF-hand motif 1391..1420 CDD:320054
EF-hand motif 1421..1450 CDD:320054
EF-hand motif 1457..1485 CDD:320054
EF-hand motif 1487..1515 CDD:320054
Blue background indicates that the domain is not in the aligned region.

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