DRSC/TRiP Functional Genomics Resources

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Protein Alignment CalpA and zgc:136872

DIOPT Version :10

Sequence 1:NP_001286613.1 Gene:CalpA / 37232 FlyBaseID:FBgn0012051 Length:843 Species:Drosophila melanogaster
Sequence 2:NP_001035341.1 Gene:zgc:136872 / 678524 ZFINID:ZDB-GENE-060421-5204 Length:693 Species:Danio rerio


Alignment Length:776 Identity:267/776 - (34%)
Similarity:396/776 - (51%) Gaps:134/776 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    88 QDYETILNSCLASGSLFEDPLFPASNESLQFS--RRPDR-HIEWLRPHEIAENPQFFVEGYSRFD 149
            ||::.:...||.....|.|.|||...:|:...  :|.|. .:.|.||:|:..||.:..:|.||||
Zfish    32 QDFQQLKQFCLKERLRFRDNLFPPELKSIGLGPLKRDDLWKVVWKRPYELVPNPVYIAQGTSRFD 96

  Fly   150 VQQGELGDCWLLAATANLTQESNLFFRVIPAEQSFEENYAGIFHFRFWQYGKWVDVIIDDRLPTY 214
            ..||.||:||.||:...||.:..:..:||..:|:|..:||||||||||::|.||||:|||:|||.
Zfish    97 FIQGRLGNCWFLASVGALTFQKRIMKQVIQDDQTFSVDYAGIFHFRFWRFGSWVDVVIDDKLPTI 161

  Fly   215 NGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCEAMEDFTGGVSEWYDLKEAPGNLFT 279
            :.:|:::.|...||||.|||||||||:.|||..:..|:..||:.|||||......|.:|...|:.
Zfish   162 DNQLVFVQSKTPNEFWPALLEKAYAKVCGSYADMDAGNISEALMDFTGGPHMTIKLSQASDKLWD 226

  Fly   280 ILQKAAERNSMMGCSIEPDPN-----VTEAETPQGLIRGHAYSITKVCLIDIVTPNRQGKIPMIR 339
            |:::|.:..|:|||.   .|.     :.....|.||:..|||::|.|  .::|...|  .:.::|
Zfish   227 IMRRAGQSESLMGCG---TPGGQAGVLQNTVLPNGLVEMHAYTVTGV--TEVVCKGR--PVKLVR 284

  Fly   340 MRNPWGNEAEWNGPWSDSSPEWRYI-PEEQKAEIGLTFDRDGEFWMSFQDFLNHFDRVEICNLSP 403
            :.||||: .|||..|||.||.|..: ||:||....|.   :||||||.:||..:|..::||....
Zfish   285 IFNPWGS-GEWNRDWSDRSPLWELVRPEDQKYNDVLD---NGEFWMSMEDFCRNFSEMDICCSDV 345

  Fly   404 DSLTEDQQNSGKRKWEMSMYEGEWTPGVTAGGCRNFLDTFWHNPQYIITLVDPDEED-EEGQCTV 467
            :.|...|.:|    |:..:::|:|..|.|||||.|.:|:|..||||.:||.:..|:. ::....:
Zfish   346 NVLAGSQSSS----WKTEVHKGQWVMGTTAGGCSNDIDSFSKNPQYRVTLKETVEDPRDKSSANL 406

  Fly   468 IVALMQKNRRSKRNMGMECLTIGFAIYS----LNDRELENRPQGLNFFRYKSSVGRSPHFINTRE 528
            :|:|:||:.:..|::... ..|||.||.    |.|:: |..|  .:|||....||::..|:|.||
Zfish   407 LVSLIQKSHKRNRHLATN-FHIGFNIYEVPAHLKDQK-EKFP--ASFFRNVRVVGKNESFLNARE 467

  Fly   529 VCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETQNNMEENDDHVGYGGKADTITPGFPTPKPI 593
            |...|:...|.||||||||.|||...|::.|:|:|:..:|   |..|||     ||.....|:..
Zfish   468 VMEFFRFKAGDYLIVPSTFQPNEASSFLLTVYSKTETIIE---DTSGYG-----ITRTKMIPRDN 524

  Fly   594 DPQKEGLRRLFDSIAGKDMEVDWMELKRILDHSMRDDLPKPVVFNRFSNNMAFETQAAGPGDDGA 658
            |...:    ||...|.|..|||...|:::|:.::.                             |
Zfish   525 DESFQ----LFLQYADKYGEVDAERLQKLLNENLH-----------------------------A 556

  Fly   659 GACGLLSLICGPFLKGTPFEEQLGMNDQSNKRLIGDNPADGGPVTANAIVDETHGFSKDVCRSMV 723
            |                          :|.|                     |.|||.|:|:|:|
Zfish   557 G--------------------------RSQK---------------------TTGFSVDLCKSLV 574

  Fly   724 AMLDADKSGKLGFEEFETLLSEIAKWKA------IFKVYDVENTGRVSGFQLREALNSAGYHLNN 782
            |::|...:|:|  .|||.|    ..||.      ||...||.:||.:|..:||.||..||:.|::
Zfish   575 ALMDLSVTGRL--SEFECL----RLWKRAVFLKDIFYDMDVSHTGSLSVNELRNALKVAGFVLSD 633

  Fly   783 RVLNVLGHRYGSRDGKIAFDDFIMCAVKIKTYIDIFKERDTEKNETATFTLEEWIERTIYS 843
            .:||::..||...:|:|:.::||:..:::......|| |.:...........||:..|:||
Zfish   634 GMLNLMALRYADSNGEISLENFIVLVLRMDCMAKTFK-RLSAGGPNMMLGENEWMHLTLYS 693

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CalpANP_001286613.1 Peptidase_C2 104..400 CDD:459889 129/304 (42%)
Calpain_III 416..569 CDD:238132 60/157 (38%)
EFh_PEF_CalpA_B 600..843 CDD:320071 59/248 (24%)
EF-hand motif 600..627 CDD:320071 9/26 (35%)
EF-hand motif 717..747 CDD:320071 12/29 (41%)
EF-hand motif 748..778 CDD:320071 14/35 (40%)
EF-hand motif 784..812 CDD:320071 8/27 (30%)
EF-hand motif 813..843 CDD:320071 6/29 (21%)
zgc:136872NP_001035341.1 Peptidase_C2 48..341 CDD:459889 128/303 (42%)
Calpain_III 361..499 CDD:460050 56/141 (40%)
EFh_PEF_CAPN13_14 526..693 CDD:320070 59/253 (23%)
EF-hand motif 526..554 CDD:320070 9/31 (29%)
EF-hand motif 569..598 CDD:320070 13/34 (38%)
EF-hand motif 599..629 CDD:320070 12/29 (41%)
EF-hand motif 635..663 CDD:320070 8/27 (30%)
EF-hand motif 665..693 CDD:320070 6/28 (21%)

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