DRSC/TRiP Functional Genomics Resources

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Protein Alignment CalpA and CAPN15

DIOPT Version :10

Sequence 1:NP_001286613.1 Gene:CalpA / 37232 FlyBaseID:FBgn0012051 Length:843 Species:Drosophila melanogaster
Sequence 2:XP_054169743.1 Gene:CAPN15 / 6650 HGNCID:11182 Length:1218 Species:Homo sapiens


Alignment Length:550 Identity:143/550 - (26%)
Similarity:213/550 - (38%) Gaps:151/550 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    90 YETILNSCLASGSLFEDPLFPASNESLQF---SRRPDRHIEWLRPHEIAENPQFFVE---GYSRF 148
            :|.|:..|..:...|.|..||...||:.|   .....|..:||||.||  |...|.:   .:|.|
Human   606 WENIVAFCRENNVSFVDDSFPPGPESVGFPAGDSVQQRVRQWLRPQEI--NCSVFRDHRATWSVF 668

  Fly   149 ------DVQQGELGDCWLLAATANLTQESNLFFRVIPAEQSFEENYAGIFHFRFWQYGKWVDVII 207
                  |:.||.||:||.|:|.|.|.:..:|..||:.......|   |.:..|..:.|.|..|::
Human   669 HTLRPSDILQGLLGNCWFLSALAVLAERPDLVERVMVTRSLCAE---GAYQVRLCKDGTWTTVLV 730

  Fly   208 DDRLPTYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCEAMEDFTGGVSEWYDL-- 270
            ||.||......:.....::.:.|.||:|||.|||||||.||:.|...|.:...||...|...|  
Human   731 DDMLPCDEAGCLLFSQAQRKQLWVALIEKALAKLHGSYFALQAGRAIEGLATLTGAPCESLALQL 795

  Fly   271 -----KEAPGNLFTILQK---AAERNSMMGCS-----IEPDPNVTEAETPQGLIRGHAYSITKVC 322
                 :|.|.:...|..|   :.|...:||.|     ::.|.:..|:   .||...|||||..| 
Human   796 SSTNPREEPVDTDLIWAKMLSSKEAGFLMGASCGGGNMKVDDSAYES---LGLRPRHAYSILDV- 856

  Fly   323 LIDIVTPNRQGKIPMIRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFDRDGEFWMSFQ 387
             .|:     || ..::|:||||| ...|||.|||..|.|   |...:.|:......:|.|||.:.
Human   857 -RDV-----QG-TRLLRLRNPWG-RFSWNGSWSDEWPHW---PGHLRGELMPHGSSEGVFWMEYG 910

  Fly   388 DFLNHFDRVEICNLSPDSLTEDQQNSGKRKWEMSMYEGEWTP------GVTAGGCRNFLDTFWHN 446
            ||:.:||.|:||.:..|             |:.:..:|.:..      ||||             
Human   911 DFVRYFDSVDICKVHSD-------------WQEARVQGCFPSSASAPVGVTA------------- 949

  Fly   447 PQYIITLVDPDEEDEEGQCTVIVALMQKNRRSKRNMGMECLTIGFAIYSLNDRELENRPQGLNFF 511
                :|:::        :.::..||.|:..|....:....|.:...:                  
Human   950 ----LTVLE--------RASLEFALFQEGSRRSDAVDSHLLDLCILV------------------ 984

  Fly   512 RYKSSVGRSPH------FINTREVCARF-----KLPPGHYLIVPSTFDPNEEGEFIIRVFSETQN 565
             ::::.|...|      ..:::....:|     .|.||.|.:|...|                  
Human   985 -FRATFGSGGHLSLGRLLAHSKRAVKKFVSCDVMLEPGEYAVVCCAF------------------ 1030

  Fly   566 NMEENDDHVGYGGKADTITPGFPTPKPIDP 595
                  :|.|      ...||.|.|:...|
Human  1031 ------NHWG------PPLPGTPAPQASSP 1048

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CalpANP_001286613.1 Peptidase_C2 104..400 CDD:459889 110/322 (34%)
Calpain_III 416..569 CDD:238132 21/169 (12%)
EFh_PEF_CalpA_B 600..843 CDD:320071
EF-hand motif 600..627 CDD:320071
EF-hand motif 717..747 CDD:320071
EF-hand motif 748..778 CDD:320071
EF-hand motif 784..812 CDD:320071
EF-hand motif 813..843 CDD:320071
CAPN15XP_054169743.1 ZnF_RBZ 137..161 CDD:197784
RanBP2-type Zn finger 139..158 CDD:275376
RanBP2-type Zn finger 180..199 CDD:275376
PRK07003 <201..>415 CDD:235906
RanBP2-type Zn finger 233..255 CDD:275375
ZnF_RBZ 277..301 CDD:197784
RanBP2-type Zn finger 279..298 CDD:275376
RanBP2-type Zn finger 476..495 CDD:275376
zf-RanBP 544..570 CDD:395516
RanBP2-type Zn finger 548..567 CDD:275376
CysPc 608..923 CDD:238004 112/334 (34%)
Blue background indicates that the domain is not in the aligned region.

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