DRSC/TRiP Functional Genomics Resources

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Protein Alignment CalpA and Capn10

DIOPT Version :10

Sequence 1:NP_001286613.1 Gene:CalpA / 37232 FlyBaseID:FBgn0012051 Length:843 Species:Drosophila melanogaster
Sequence 2:NP_113861.1 Gene:Capn10 / 63834 RGDID:69354 Length:666 Species:Rattus norvegicus


Alignment Length:514 Identity:171/514 - (33%)
Similarity:248/514 - (48%) Gaps:100/514 - (19%)


- Green bases have known domain annotations that are detailed below.


  Fly   103 LFEDPLFPASNESL---------QFSRRPDRHIEWLRPHEIAENPQFFVEGYSRFDVQQGELGDC 158
            ||.|..||||:.||         ||  |.|  |.|.||.:|...||.|.:......|:||.||||
  Rat    13 LFRDAAFPASDSSLFYNLSTPLAQF--RED--ITWRRPQDICATPQLFPDNPWEGQVKQGLLGDC 73

  Fly   159 WLLAATANLTQESNLFFRVIPAEQS--FEENYAGIFHFRFWQYGKWVDVIIDDRLPTYNGELMYM 221
            |.|.|.|.|.:..:|..:|.|..|.  .::.|.|.|..|.||:|.|.:|.||||||...|.|.:.
  Rat    74 WFLCACAALQKSRHLLDQVFPPGQPGWSDQEYQGFFTCRIWQFGHWEEVTIDDRLPCLAGRLCFS 138

  Fly   222 HSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCEAMEDFTGGVSEWYDLKEAPGNLFTILQKAA- 285
            ....::.||..||||||||:|||||.|..|...:|:.|.||.::|.:.||:        ::||: 
  Rat   139 RCQREDVFWLPLLEKAYAKVHGSYEHLWAGQVADALVDLTGSLAERWSLKD--------IRKASG 195

  Fly   286 --ERNS-----------------MMGCSI-EPDPNVTEAETPQGLIRGHAYSITKVCLIDIVTPN 330
              :|.|                 ::.||: .|.....|      |...||:.|:.  |.::.:..
  Rat   196 QQDRPSGGEHRACQQLLRLKDQCLLSCSVLSPRAGARE------LGEFHAFIISD--LQELRSQT 252

  Fly   331 RQGKIPMIRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFDRDGEFWMSFQDFLNHFDR 395
            .|| |.::|:.||||... |.|.|.:....|..:...:::|: |...::||||:..::||..||.
  Rat   253 GQG-ILLLRIHNPWGRRC-WQGLWREGGEGWNQVEPAKESEL-LAQLQEGEFWVEEEEFLREFDE 314

  Fly   396 VEICNLSPDSLTEDQQNSGKRKWEMSMY-----------EGEWTPGVTAGGCRNFLDTFWHNPQY 449
            |.|    ...:||    :|..:   |:|           .|.|..|.:|||||| ...|..||::
  Rat   315 VTI----GYPVTE----AGHLQ---SLYTEKVLCHTRALPGAWVTGQSAGGCRN-NSCFPCNPKF 367

  Fly   450 IITLVDPDEEDEEGQCTVIVALMQKNRRSKRNMGMECLTIGFAIYSLNDRELENRPQGLNFFRY- 513
            .:.|::|.|        |.||::|:.||  |.:|......|.:...:|....:.:..||:.::. 
  Rat   368 WLRLLEPSE--------VCVAVLQRPRR--RLVGQTRALAGASPAPVNLPGKDYQAVGLHIWKVE 422

  Fly   514 --KSSVGR---SPHFINT------REVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFS 561
              |.|:.|   :|....|      ||:..|.:|.||:||.|||||..:..|:|::||||
  Rat   423 KRKISLPRVLSAPPVAGTACHAYDREIHLRCELSPGYYLAVPSTFLKDVPGQFLLRVFS 481

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CalpANP_001286613.1 Peptidase_C2 104..400 CDD:459889 114/327 (35%)
Calpain_III 416..569 CDD:238132 53/169 (31%)
EFh_PEF_CalpA_B 600..843 CDD:320071
EF-hand motif 600..627 CDD:320071
EF-hand motif 717..747 CDD:320071
EF-hand motif 748..778 CDD:320071
EF-hand motif 784..812 CDD:320071
EF-hand motif 813..843 CDD:320071
Capn10NP_113861.1 CysPc 8..319 CDD:238004 115/332 (35%)
Domain III 1 322..488 56/178 (31%)
calpain_III 338..488 CDD:214786 51/155 (33%)
Calpain_III 506..647 CDD:238132
Domain III 2 507..648
Blue background indicates that the domain is not in the aligned region.

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