DRSC/TRiP Functional Genomics Resources

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Protein Alignment CalpA and si:dkeyp-50d11.2

DIOPT Version :10

Sequence 1:NP_001286613.1 Gene:CalpA / 37232 FlyBaseID:FBgn0012051 Length:843 Species:Drosophila melanogaster
Sequence 2:XP_021329108.1 Gene:si:dkeyp-50d11.2 / 565825 ZFINID:ZDB-GENE-091113-22 Length:704 Species:Danio rerio


Alignment Length:770 Identity:320/770 - (41%)
Similarity:443/770 - (57%) Gaps:114/770 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    88 QDYETILNSCLASGSLFEDPLFPASNESLQF-----SRRPDRHIEWLRPHEIAENPQFFVEGYSR 147
            ||:|::...||.||.||||.:|||...||.|     :....|.:.|:||.|...:|.|.|:|.:|
Zfish    35 QDFESLRTRCLQSGHLFEDDIFPAQQSSLGFKELGPNSSKTRGVRWMRPTEFCSDPHFIVDGATR 99

  Fly   148 FDVQQGELGDCWLLAATANLTQESNLFFRVIPAEQSFEENYAGIFHFRFWQYGKWVDVIIDDRLP 212
            .|:.||.|||||||||.|.||....|..||:|..|||.:.|||||||:|||:|.||||:||||||
Zfish   100 TDICQGALGDCWLLAAIACLTLNEPLLRRVVPHGQSFHQQYAGIFHFQFWQFGDWVDVVIDDRLP 164

  Fly   213 TYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCEAMEDFTGGVSEWYDLKEAPGNL 277
            ..:|:|:::||.|.:||||||:|||||||:|.||||.||||.|..|||||||:|.|:||.||.||
Zfish   165 VRDGKLLFVHSAEGSEFWSALVEKAYAKLNGCYEALSGGSTSEGFEDFTGGVTEMYELKNAPPNL 229

  Fly   278 FTILQKAAERNSMMGCSIEPDPNVT-----EAETPQGLIRGHAYSITKVCLIDIVTPNRQGKIPM 337
            |:|:.:|.||.|:|||||:    :|     ||.|.:.|::|||||||.|..::.    |:.:..:
Zfish   230 FSIITRAVERGSLMGCSID----ITSFFDMEAITFKKLVKGHAYSITGVDEVEY----RRSQTKL 286

  Fly   338 IRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFDRDGEFWMSFQDFLNHFDRVEICNLS 402
            :|:||||| |.||.|||||.|.|||.|....::.:. ....||||||:|.||...|.|:|||||:
Zfish   287 LRIRNPWG-EVEWTGPWSDESKEWREIDASVRSRLH-NSQEDGEFWMAFSDFKREFSRLEICNLT 349

  Fly   403 PDSLTEDQQNSGKRKWEMSMYEGEWTPGVTAGGCRNFLDTFWHNPQYIITLVDPDEEDEEGQCTV 467
            .|:|    |:...:||..|:|.|||..|.|||||||:..|||.|||:.|.|.:||.:::|| ||.
Zfish   350 ADAL----QSREVKKWNSSLYPGEWRRGSTAGGCRNYPATFWINPQFKIVLKEPDTDNQEG-CTF 409

  Fly   468 IVALMQKNRRSKRNMGMECLTIGFAIYSLNDRELENRPQGL--NFFRYKSSVGRSPHFINTREVC 530
            :|||||||||..|..|.:..|||||||.:....|......|  :||...:|..||..|||.|||.
Zfish   410 LVALMQKNRRQLRREGKDMETIGFAIYEVPKEYLGRVGVHLKRDFFLKHTSSARSELFINLREVS 474

  Fly   531 ARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETQNNMEENDDHVGYGGKADTITPGFPTPKPIDP 595
            :||.||.|.|:||||||:|.:||:|::|||||...:.:|.||.:    .||  .|..|..:..|.
Zfish   475 SRFSLPAGEYIIVPSTFEPQKEGDFVLRVFSEKATDSQELDDEI----SAD--VPEEPVLQESDI 533

  Fly   596 QKEGLRRLFDSIAGKDMEVDWMELKRILDH--SMRDDLPKPVVFNRFSNNMAFETQAAGPGDDGA 658
            . ||.:.||..:||.:||::..:|:.||:.  |...|:                           
Zfish   534 D-EGFKALFAKLAGPEMEINVAKLEMILNRVVSKHKDI--------------------------- 570

  Fly   659 GACGLLSLICGPFLKGTPFEEQLGMNDQSNKRLIGDNPADGGPVTANAIVDETHGFSKDVCRSMV 723
                                                               :|.||.|:.||.|:
Zfish   571 ---------------------------------------------------KTDGFGKETCRGMI 584

  Fly   724 AMLDADKSGKLGFEEFETLLSEIAKWKAIFKVYDVENTGRVSGFQLREALNSAGYHLNNRVLNVL 788
            .::|...:||||..:|..|..:..::.|:|:.:|::.:|.:|.:::|.||.|||:.|.|.:..::
Zfish   585 NLMDTTGTGKLGLTDFHVLWEKFKRYLAVFREFDIDKSGTMSSYEMRLALESAGFKLTNNLFQLI 649

  Fly   789 GHRYGSRDGKIAFDDFIMCAVKIKTYIDIFKERDTEKNETATFTLEEWIERTIYS 843
            ..||...|..:.||:|:.|.::::|....||..|.:::...:|:..:||..|:::
Zfish   650 ILRYAKSDLNVDFDNFVACLIRLETMFKTFKTLDADEDGLVSFSFAQWITLTMFT 704

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CalpANP_001286613.1 Peptidase_C2 104..400 CDD:459889 162/305 (53%)
Calpain_III 416..569 CDD:238132 81/154 (53%)
EFh_PEF_CalpA_B 600..843 CDD:320071 53/244 (22%)
EF-hand motif 600..627 CDD:320071 9/28 (32%)
EF-hand motif 717..747 CDD:320071 10/29 (34%)
EF-hand motif 748..778 CDD:320071 10/29 (34%)
EF-hand motif 784..812 CDD:320071 7/27 (26%)
EF-hand motif 813..843 CDD:320071 8/29 (28%)
si:dkeyp-50d11.2XP_021329108.1 Peptidase_C2 51..347 CDD:459889 162/305 (53%)
Calpain_III 359..514 CDD:238132 81/155 (52%)
EFh_PEF 536..703 CDD:355382 54/244 (22%)
EF-hand motif 536..564 CDD:320073 10/27 (37%)
EF-hand motif 579..608 CDD:320073 10/28 (36%)
EF-hand motif 609..638 CDD:320073 9/28 (32%)
EF-hand motif 645..673 CDD:320073 7/27 (26%)
EF-hand motif 675..703 CDD:320073 7/27 (26%)

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