DRSC/TRiP Functional Genomics Resources

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Protein Alignment CalpA and capn1b

DIOPT Version :10

Sequence 1:NP_001286613.1 Gene:CalpA / 37232 FlyBaseID:FBgn0012051 Length:843 Species:Drosophila melanogaster
Sequence 2:XP_005174088.1 Gene:capn1b / 565106 ZFINID:ZDB-GENE-060503-491 Length:704 Species:Danio rerio


Alignment Length:771 Identity:329/771 - (42%)
Similarity:450/771 - (58%) Gaps:118/771 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    88 QDYETILNSCLASGSLFEDPLFPASNESLQFSR-RPD----RHIEWLRPHEIAENPQFFVEGYSR 147
            ||||.:...|:.||.|||||.|||..:||.|.. .|:    |.::|:||.|::|||||.|.|.:|
Zfish    33 QDYEELRRECVESGRLFEDPCFPAVPQSLGFKELAPNSSKTRGVKWIRPTELSENPQFIVGGATR 97

  Fly   148 FDVQQGELGDCWLLAATANLTQESNLFFRVIPAEQSFEENYAGIFHFRFWQYGKWVDVIIDDRLP 212
            .|:.||.|||||||||.|:||....|..||:|..|||...|||||||:|||:|:|||::||||||
Zfish    98 TDICQGALGDCWLLAAIASLTLNDKLLHRVVPHGQSFTNEYAGIFHFQFWQFGEWVDIVIDDRLP 162

  Fly   213 TYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCEAMEDFTGGVSEWYDLKEAPGNL 277
            ..:.|||::||.|.|||||||||||||||:||||||.||||.|..|||||||:|.|:|:.||.:|
Zfish   163 VKDKELMFVHSAEGNEFWSALLEKAYAKLNGSYEALSGGSTTEGFEDFTGGVAEMYELRSAPKDL 227

  Fly   278 FTILQKAAERNSMMGCSIEPDPNVT-----EAETPQGLIRGHAYSITKVCLIDIVTPNRQGKIPM 337
            ..|:.||.||.|::||||:    :|     ||.|.:.|::|||||:|.:..::.    |..:..:
Zfish   228 HRIIAKALERGSLLGCSID----ITSAFDMEAVTFKKLVKGHAYSVTALREVNF----RGNRERL 284

  Fly   338 IRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFDRDGEFWMSFQDFLNHFDRVEICNLS 402
            ||:||||| :.||.|.|||:|.||..|...::.|:....: |||||||||:|...|.|:|||||:
Zfish   285 IRIRNPWG-QVEWTGAWSDNSSEWNGIDPSEREELNNHME-DGEFWMSFQEFKRQFSRLEICNLT 347

  Fly   403 PDSLTEDQQNSGKRKWEMSMYEGEWTPGVTAGGCRNFLDTFWHNPQYIITLV--DPDEEDEEGQC 465
            ||:|::|.|:.    |....:.|.|..|.|||||||..:|||.||||.|||:  |.|.||.|..|
Zfish   348 PDALSDDSQHF----WNTIQFNGTWRKGSTAGGCRNNPNTFWINPQYKITLLEEDDDPEDNEVAC 408

  Fly   466 TVIVALMQKNRRSKRNMGMECLTIGFAIYSLNDRELENRPQGL--NFFRYKSSVGRSPHFINTRE 528
            |.:||||||:||..|..|.:..|||||:|.:.|..|.::...|  :||...||..||..|||.||
Zfish   409 TFMVALMQKDRRRFRKQGQDMHTIGFALYEVPDEFLGSQNVHLKKDFFLRHSSCARSETFINLRE 473

  Fly   529 VCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETQNNMEENDDHVGYGGKADTITPGFPTPKPI 593
            |..|.:||||.||||||||:|.:|.:|::|||:|.|:..:|.||.:.:..:.:...    :.:.|
Zfish   474 VSTRLRLPPGEYLIVPSTFEPGKEADFVLRVFTEKQSETQEMDDEISFNLEDEEAV----SEENI 534

  Fly   594 DPQKEGLRRLFDSIAGKDMEVDWMELKRILDHSM---RDDLPKPVVFNRFSNNMAFETQAAGPGD 655
            |   ...:::|..::|:|||:...||:.||:..|   ||                          
Zfish   535 D---ASFKKMFAQLSGEDMEISVHELRTILNRVMTKHRD-------------------------- 570

  Fly   656 DGAGACGLLSLICGPFLKGTPFEEQLGMNDQSNKRLIGDNPADGGPVTANAIVDETHGFSKDVCR 720
                            ||                                     |.|||.:.||
Zfish   571 ----------------LK-------------------------------------TDGFSLESCR 582

  Fly   721 SMVAMLDADKSGKLGFEEFETLLSEIAKWKAIFKVYDVENTGRVSGFQLREALNSAGYHLNNRVL 785
            .|:.::|.|.|.:||..||:.|.::|.||..:|:.:|::.:|.:|.:::|.|:.|||:.|||::.
Zfish   583 CMINLMDKDGSARLGIVEFQILWNKIRKWLGVFRQFDLDKSGTMSSYEMRLAVESAGFKLNNKLH 647

  Fly   786 NVLGHRYGSRDGKIAFDDFIMCAVKIKTYIDIFKERDTEKNETATFTLEEWIERTI 841
            .:|..||...| .|.||:|:.|.||::.....|||.:.|.:..|...:.||:..|:
Zfish   648 QILVARYSDGD-VIDFDNFVCCLVKLEAMFKSFKELEKEGSGVAELNISEWLYLTM 702

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CalpANP_001286613.1 Peptidase_C2 104..400 CDD:459889 165/305 (54%)
Calpain_III 416..569 CDD:238132 80/156 (51%)
EFh_PEF_CalpA_B 600..843 CDD:320071 63/245 (26%)
EF-hand motif 600..627 CDD:320071 9/26 (35%)
EF-hand motif 717..747 CDD:320071 11/29 (38%)
EF-hand motif 748..778 CDD:320071 10/29 (34%)
EF-hand motif 784..812 CDD:320071 11/27 (41%)
EF-hand motif 813..843 CDD:320071 8/29 (28%)
capn1bXP_005174088.1 Peptidase_C2 49..345 CDD:459889 165/305 (54%)
Calpain_III 357..515 CDD:238132 80/161 (50%)
EFh_PEF 537..704 CDD:355382 63/246 (26%)
EF-hand motif 537..565 CDD:320054 9/27 (33%)
EF-hand motif 580..609 CDD:320054 11/28 (39%)
EF-hand motif 610..639 CDD:320054 9/28 (32%)
EF-hand motif 646..673 CDD:320054 11/27 (41%)
EF-hand motif 675..703 CDD:320054 8/28 (29%)

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