DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CalpA and capn1

DIOPT Version :10

Sequence 1:NP_001286613.1 Gene:CalpA / 37232 FlyBaseID:FBgn0012051 Length:843 Species:Drosophila melanogaster
Sequence 2:NP_001013632.1 Gene:capn1 / 541455 XenbaseID:XB-GENE-990196 Length:713 Species:Xenopus tropicalis


Alignment Length:812 Identity:321/812 - (39%)
Similarity:454/812 - (55%) Gaps:145/812 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    61 LQSQSNSTLYYGNLGEKSSSLGPYSEVQDYETILNSCLASGSLFEDPLFPASNESLQFSR-RPDR 124
            ||.|.:..|..|........||     |||:.||:.||.:.:||:|..||.|..||.|.. .|:.
 Frog    18 LQKQRDQELGVGKHENAVKFLG-----QDYDRILHECLQNRTLFKDDTFPPSAYSLGFKELGPNS 77

  Fly   125 H----IEWLRPHEIAENPQFFVEGYSRFDVQQGELGDCWLLAATANLTQESNLFFRVIPAEQSFE 185
            .    ::|:||.::..||||.|:|.:|.|:.||.|||||||||.|:||....:..||:|..|||:
 Frog    78 SKTYGVKWVRPSQLVSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNDTILHRVVPHGQSFQ 142

  Fly   186 ENYAGIFHFRFWQYGKWVDVIIDDRLPTYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKG 250
            :||||:|||:.||:|:||||:|||.||..:|:|:::||...||||||||||||||.:|.||||.|
 Frog   143 DNYAGVFHFQLWQFGEWVDVVIDDYLPVKDGKLVFVHSASGNEFWSALLEKAYAKANGCYEALSG 207

  Fly   251 GSTCEAMEDFTGGVSEWYDLKEAPGNLFTILQKAAERNSMMGCSIEPDPNVT-----EAETPQGL 310
            |||.|..|||||||:|||::|:||.:||:|:.||.||.|:|||||:    :|     ||.|.:.|
 Frog   208 GSTSEGFEDFTGGVTEWYEMKKAPKDLFSIIMKAVERGSLMGCSID----ITSATDMEAVTFKKL 268

  Fly   311 IRGHAYSITKVCLIDIVTPNRQGKI-PMIRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGL 374
            ::|||||:|....|     |.:|:. .:|||||||| |.||.|.|||:|.||..:......::.:
 Frog   269 VKGHAYSVTGAKEI-----NFRGRSQKLIRMRNPWG-EVEWTGAWSDNSSEWNSVDAADSQDLRI 327

  Fly   375 TFDRDGEFWMSFQDFLNHFDRVEICNLSPDSLTEDQQNSGKRKWEMSMYEGEWTPGVTAGGCRNF 439
            ..: ||||||:|:|||..|.|:|||||:||:||..:.    |||..:::.|.|..|.||||||||
 Frog   328 KME-DGEFWMAFEDFLREFSRLEICNLTPDALTARKY----RKWNTTVFNGNWRKGSTAGGCRNF 387

  Fly   440 LDTFWHNPQYIITLVDPDEEDEEGQ---CTVIVALMQKNRRSKRNMGMECLTIGFAIYSLNDREL 501
            ..|||.|||:.|.|.:.|::|:.|.   ||.::|||||::|.:|..|.:..|||||:|     |:
 Frog   388 PATFWINPQFKIKLDEEDDDDDFGSEKGCTFLLALMQKDKRKERRFGKDMETIGFAVY-----EV 447

  Fly   502 ENRPQG-------LNFFRYKSSVGRSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRV 559
            .::..|       .:||...:|..||..|||.|||..|.|||||.|::|||||:||.||:|::|.
 Frog   448 PSQFHGQSGVHLKRDFFLQNASRARSEQFINLREVSTRHKLPPGEYIVVPSTFEPNVEGDFVVRF 512

  Fly   560 FSETQNNMEENDDHVGYGGKADTITPGFPTPKPIDPQK--------EGLRRLFDSIAGKDMEVDW 616
            |||.::...|.||               |....:.|::        :|.:.||..:||.|.|:..
 Frog   513 FSENKHGSVEMDD---------------PLSADLPPEEVLSEAEIDQGFKNLFKQLAGADNEISA 562

  Fly   617 MELKRILDHSMRDDLPKPVVFNRFSNNMAFETQAAGPGDDGAGACGLLSLICGPFLKGTPFEEQL 681
            .||:.||:..|                                                      
 Frog   563 TELQSILNKIM------------------------------------------------------ 573

  Fly   682 GMNDQSNKRLIGDNPADGGPVTANAIVDETHGFSKDVCRSMVAMLDADKSGKLGFEEFETLLSEI 746
                ..:|.|                  .|.|||.:.|||||.::|.|.:||||..||..|.::|
 Frog   574 ----SKHKDL------------------RTSGFSLESCRSMVNLMDKDGNGKLGLVEFNVLWNKI 616

  Fly   747 AKWKAIFKVYDVENTGRVSGFQLREALNSAGYHLNNRVLNVLGHRYGSRDGKIAFDDFIMCAVKI 811
            ..:..:|:.:|::.:|.:|.:::|.|:.|||:.|.|.:..::..||...|..:.||.|..|.:::
 Frog   617 KNYLTVFRKFDMDKSGSMSAYEMRLAVESAGFKLTNSLHQLIITRYSEPDMAVNFDSFTCCLIRL 681

  Fly   812 KTYIDIFKERDTEKNETATFTLEEWIERTIYS 843
            :|....|:..||||.....|.:.:|::.|:::
 Frog   682 ETMFRFFQGMDTEKKGVIHFDIFKWLQMTMFA 713

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CalpANP_001286613.1 Peptidase_C2 104..400 CDD:459889 159/306 (52%)
Calpain_III 416..569 CDD:238132 75/162 (46%)
EFh_PEF_CalpA_B 600..843 CDD:320071 59/242 (24%)
EF-hand motif 600..627 CDD:320071 10/26 (38%)
EF-hand motif 717..747 CDD:320071 14/29 (48%)
EF-hand motif 748..778 CDD:320071 8/29 (28%)
EF-hand motif 784..812 CDD:320071 7/27 (26%)
EF-hand motif 813..843 CDD:320071 9/29 (31%)
capn1NP_001013632.1 Peptidase_C2 56..352 CDD:459889 159/306 (52%)
Calpain_III 364..523 CDD:238132 75/163 (46%)
EFh_PEF_CAPN1 545..713 CDD:320073 60/243 (25%)
EF-hand motif 545..573 CDD:320073 11/27 (41%)
EF-hand motif 588..617 CDD:320073 14/28 (50%)
EF-hand motif 618..648 CDD:320073 8/29 (28%)
EF-hand motif 654..682 CDD:320073 7/27 (26%)
EF-hand motif 684..713 CDD:320073 8/28 (29%)

Return to query results.
Submit another query.