DRSC/TRiP Functional Genomics Resources

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Protein Alignment CalpA and capn11

DIOPT Version :10

Sequence 1:NP_001286613.1 Gene:CalpA / 37232 FlyBaseID:FBgn0012051 Length:843 Species:Drosophila melanogaster
Sequence 2:XP_031757539.1 Gene:capn11 / 541454 XenbaseID:XB-GENE-940593 Length:713 Species:Xenopus tropicalis


Alignment Length:783 Identity:324/783 - (41%)
Similarity:456/783 - (58%) Gaps:127/783 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    77 KSSSLGPYS-----EVQDYETILNSCLASGSLFEDPLFPASNESLQFSR-----RPDRHIEWLRP 131
            |:|.:|.:.     :.||||::...|..||||||||.||....||.|..     ...:.::|.||
 Frog    17 KASGVGSHDCAVRYQNQDYESLKQQCRESGSLFEDPNFPPIGSSLGFKELGPGTSKTKGVQWKRP 81

  Fly   132 HEIAENPQFFVEGYSRFDVQQGELGDCWLLAATANLTQESNLFFRVIPAEQSFEENYAGIFHFRF 196
            |:||::|||.|.|.:|.|:.||.|||||||||..:||...:|..||:|..|.|:::|||||||:.
 Frog    82 HDIADDPQFIVGGATRTDICQGALGDCWLLAAIGSLTLNEDLLHRVVPHGQGFQDDYAGIFHFQI 146

  Fly   197 WQYGKWVDVIIDDRLPTYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCEAMEDFT 261
            ||:|:||||:||||||..:|||:::||.|.:||||||||||||||:||||||.||||.|..||||
 Frog   147 WQFGEWVDVVIDDRLPVKDGELVFVHSAECSEFWSALLEKAYAKLNGSYEALSGGSTTEGFEDFT 211

  Fly   262 GGVSEWYDLKEAPGNLFTILQKAAERNSMMGCSIEPDPNVT-----EAETPQGLIRGHAYSITKV 321
            |||:|.|:|::||.||..|:::|.:|.|::||||:    :|     ||.|.:.|::|||||:|.:
 Frog   212 GGVAEMYELRKAPRNLDKIIKRALDRGSLLGCSID----ITSAFDMEAVTFKKLVKGHAYSVTAL 272

  Fly   322 CLIDIVTPNRQGKI-PMIRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFDRDGEFWMS 385
            ..:     |..|.: .:||:||||| :.||.|.|||:|.||..:...::.::.|..: |||||||
 Frog   273 REV-----NYMGGVEKLIRIRNPWG-QVEWTGAWSDNSSEWNEVDPSEQEDLQLKME-DGEFWMS 330

  Fly   386 FQDFLNHFDRVEICNLSPDSLTEDQQNSGKRKWEMSMYEGEWTPGVTAGGCRNFLDTFWHNPQYI 450
            ||:||..|.|:|||||:||:|.:|    |:.||..::|:|.|..|.|||||||...|||.|||:.
 Frog   331 FQEFLRQFSRLEICNLTPDALDKD----GQSKWHSTLYDGTWRRGSTAGGCRNNPATFWINPQFK 391

  Fly   451 ITLV--DPDEEDEEGQCTVIVALMQKNRRSKRNMGMECLTIGFAIYSLND--RELENRPQGLNFF 511
            :||:  |.|.:|.|..|:.:|||||||||.:|.:|.:..|||||:|.:.|  |..:|.....:||
 Frog   392 VTLLEEDDDPDDNELACSFLVALMQKNRRKERKVGQDMHTIGFAVYEVPDEFRGCQNVHLKKDFF 456

  Fly   512 RYKSSVGRSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETQNNMEENDDHVGY 576
            ....|..||..|||.|||..:.:||||.|:||||||:|::|.:|::|:|:|..::::|.|:.|  
 Frog   457 LRHQSCARSETFINLREVSTQIRLPPGEYIIVPSTFEPHKEADFVLRIFTEKHSDIQELDEEV-- 519

  Fly   577 GGKADTITPGFPTPKPI--DPQKEGLRRLFDSIAGKDMEVDWMELKRILDH--SMRDDLPKPVVF 637
              .||     .|..:.:  |...:..:.:|..:||:|||:...|||.||:.  :...||      
 Frog   520 --SAD-----LPEEEELTEDDVDDSFKAMFRQLAGEDMEISVFELKTILNRVVAKHKDL------ 571

  Fly   638 NRFSNNMAFETQAAGPGDDGAGACGLLSLICGPFLKGTPFEEQLGMNDQSNKRLIGDNPADGGPV 702
                                                                             
 Frog   572 ----------------------------------------------------------------- 571

  Fly   703 TANAIVDETHGFSKDVCRSMVAMLDADKSGKLGFEEFETLLSEIAKWKAIFKVYDVENTGRVSGF 767
                   :|.||..:.||.||.::|.|.|||||..||:.|.::|.:|...|:.:|::.:|.:|.:
 Frog   572 -------KTDGFGMEACRQMVNLMDKDGSGKLGVVEFQILWNKIRQWLTAFRQHDLDKSGTISAY 629

  Fly   768 QLREALNSAGYHLNNRVLNVLGHRYGSRDGKIAFDDFIMCAVKIKTYIDIFKERDTEKNETATFT 832
            :||.||...||.|||:::.||..||...|..|.||:|:.|.||::.....||..| :...||..:
 Frog   630 ELRIALEGTGYKLNNKLIQVLVARYADSDMGIDFDNFVCCLVKLEAMFRFFKALD-QGEGTAEMS 693

  Fly   833 LEE 835
            |.|
 Frog   694 LGE 696

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CalpANP_001286613.1 Peptidase_C2 104..400 CDD:459889 159/306 (52%)
Calpain_III 416..569 CDD:238132 74/156 (47%)
EFh_PEF_CalpA_B 600..843 CDD:320071 64/238 (27%)
EF-hand motif 600..627 CDD:320071 11/28 (39%)
EF-hand motif 717..747 CDD:320071 14/29 (48%)
EF-hand motif 748..778 CDD:320071 9/29 (31%)
EF-hand motif 784..812 CDD:320071 12/27 (44%)
EF-hand motif 813..843 CDD:320071 7/23 (30%)
capn11XP_031757539.1 Peptidase_C2 49..345 CDD:459889 159/306 (52%)
Calpain_III 358..515 CDD:238132 74/156 (47%)
EFh_PEF 537..696 CDD:355382 63/237 (27%)
EF-hand motif 537..565 CDD:320054 11/27 (41%)
EF-hand motif 580..609 CDD:320054 14/28 (50%)
EF-hand motif 610..639 CDD:320054 9/28 (32%)
EF-hand motif 646..674 CDD:320054 12/27 (44%)

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