DRSC/TRiP Functional Genomics Resources

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Protein Alignment CalpA and capn2a

DIOPT Version :10

Sequence 1:NP_001286613.1 Gene:CalpA / 37232 FlyBaseID:FBgn0012051 Length:843 Species:Drosophila melanogaster
Sequence 2:NP_001013519.1 Gene:capn2a / 541374 ZFINID:ZDB-GENE-050320-69 Length:698 Species:Danio rerio


Alignment Length:771 Identity:306/771 - (39%)
Similarity:430/771 - (55%) Gaps:128/771 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    88 QDYETILNSCLASGSLFEDPLFPASNESLQFSR-----RPDRHIEWLRPHEIAENPQFFVEGYSR 147
            |::||:.:.||:.|.||.||.|||:.|:|.|:.     ...|.:||.||.::..:|:|.|.|.:|
Zfish    30 QNFETLRSECLSRGELFCDPAFPAAPEALGFNELGPRSSKTRGVEWKRPGQLNSSPEFIVGGATR 94

  Fly   148 FDVQQGELGDCWLLAATANLTQESNLFFRVIPAEQSFEENYAGIFHFRFWQYGKWVDVIIDDRLP 212
            .|:.||.|||||||||.|:||...::..||:|::|.|.::|||||||:|||:|:||||::|||||
Zfish    95 TDICQGALGDCWLLAAIASLTLNEDVLARVVPSDQGFGQDYAGIFHFQFWQFGEWVDVVVDDRLP 159

  Fly   213 TYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCEAMEDFTGGVSEWYDLKEAPGNL 277
            |.:|||:::||...:|||||||||||||::|.||||.||||.|..||||||::|.|:||.||.||
Zfish   160 TRDGELLFVHSVTGSEFWSALLEKAYAKVNGCYEALSGGSTTEGFEDFTGGIAEMYELKSAPTNL 224

  Fly   278 FTILQKAAERNSMMGCSIEPDPNVT-----EAETPQGLIRGHAYSITKVCLIDIVTPNRQGKIPM 337
            |.|::||.:..:::||||:    :|     ||.|.|.|::|||||:|....::.    |..|..:
Zfish   225 FQIIKKALDSGALLGCSID----ITSAADSEAVTYQKLVKGHAYSLTGATEVNY----RSRKEKL 281

  Fly   338 IRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFDRDGEFWMSFQDFLNHFDRVEICNLS 402
            :|:||||| :.||.|.|||:|.||..:...::..:.   ..||||||||.||:..:.|:|||.|:
Zfish   282 VRVRNPWG-QVEWTGAWSDNSSEWNAVDPSERENVK---SEDGEFWMSFSDFVRQYSRLEICTLT 342

  Fly   403 PDSLTEDQQNSGKRKWEMSMYEGEWTPGVTAGGCRNFLDTFWHNPQYIITL--VDPDEEDEEGQC 465
            ||:||.|    ..:.|.:..::|.|..|.|||||||...|||.|||:.|.|  .|.|.:|.|..|
Zfish   343 PDTLTSD----SLKHWSVCKFDGTWRKGSTAGGCRNHPYTFWMNPQFKIKLEEEDDDPDDNEVGC 403

  Fly   466 TVIVALMQKNRRSKRNMGMECLTIGFAIYSLNDRELENRPQGL--NFFRYKSSVGRSPHFINTRE 528
            :|::.|:|||||..|..|.:..|||:|||.:..:....:...|  |:|...:...||..|||.||
Zfish   404 SVVIGLIQKNRRKMRKAGEDMHTIGYAIYEVPSQFHGQKEVHLDKNYFLTHAQKARSETFINLRE 468

  Fly   529 VCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETQNNMEENDDHVGYGGKADTITPGFPTPKPI 593
            |..|||||||.||||||||||::.|:|.:|||||.|:.|::.||               |....:
Zfish   469 VSTRFKLPPGEYLIVPSTFDPHKNGDFCVRVFSEKQSEMQQCDD---------------PIEANV 518

  Fly   594 DPQ-------KEGLRRLFDSIAGKDMEVDWMELKRILDHSMRDDLPKPVVFNRFSNNMAFETQAA 651
            |.:       ..|.|.||..:||.|||:...||:              .:||:            
Zfish   519 DDEMVSEEEVDSGFRGLFTKLAGDDMEISASELR--------------TIFNK------------ 557

  Fly   652 GPGDDGAGACGLLSLICGPFLKGTPFEEQLGMNDQSNKRLIGDNPADGGPVTANAIVDETHGFSK 716
                                                              :.|.....:|.|||.
Zfish   558 --------------------------------------------------IVAKRTDIKTDGFSL 572

  Fly   717 DVCRSMVAMLDADKSGKLGFEEFETLLSEIAKWKAIFKVYDVENTGRVSGFQLREALNSAGYHLN 781
            |.||.||.::|...:||||..||.||..:|.|:..|:|..|::.:|.:|..::|.||..||:.||
Zfish   573 DTCRVMVNLMDESGNGKLGLTEFATLWKKIQKYLGIYKKNDMDGSGCMSTPEMRMALKEAGFSLN 637

  Fly   782 NRVLNVLGHRYGSRDGKIAFDDFIMCAVKIKTYIDIFKERDTEKNETATFTLEEWI 837
            :.:...|..|||..|..|.||:|:.|.::::....:||..|.:.:........:|:
Zfish   638 DCIHQSLAARYGDADMTIDFDNFVSCVMRLEMMFKVFKRMDIDHSGFIELDFFQWL 693

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CalpANP_001286613.1 Peptidase_C2 104..400 CDD:459889 152/305 (50%)
Calpain_III 416..569 CDD:238132 76/156 (49%)
EFh_PEF_CalpA_B 600..843 CDD:320071 59/238 (25%)
EF-hand motif 600..627 CDD:320071 10/26 (38%)
EF-hand motif 717..747 CDD:320071 14/29 (48%)
EF-hand motif 748..778 CDD:320071 10/29 (34%)
EF-hand motif 784..812 CDD:320071 10/27 (37%)
EF-hand motif 813..843 CDD:320071 4/25 (16%)
capn2aNP_001013519.1 Peptidase_C2 46..339 CDD:459889 151/304 (50%)
Calpain_III 359..500 CDD:460050 69/140 (49%)
EFh_PEF_CAPN1_like 531..698 CDD:320064 60/239 (25%)
EF-hand motif 531..559 CDD:320064 13/103 (13%)
EF-hand motif 574..603 CDD:320064 13/28 (46%)
EF-hand motif 604..634 CDD:320064 10/29 (34%)
EF-hand motif 640..668 CDD:320064 10/27 (37%)
EF-hand motif 670..698 CDD:320064 4/24 (17%)

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