DRSC/TRiP Functional Genomics Resources

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Protein Alignment CalpA and capn5

DIOPT Version :10

Sequence 1:NP_001286613.1 Gene:CalpA / 37232 FlyBaseID:FBgn0012051 Length:843 Species:Drosophila melanogaster
Sequence 2:NP_001006736.1 Gene:capn5 / 448405 XenbaseID:XB-GENE-947203 Length:642 Species:Xenopus tropicalis


Alignment Length:663 Identity:236/663 - (35%)
Similarity:350/663 - (52%) Gaps:107/663 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    79 SSLGPYSEVQDYETILNSCLASGSLFEDPLFPASNESLQFSRRPDRHIEWLRPHEIAENPQFFVE 143
            ||..|:.. |.|:.:...|.:...|||||:|||:|::|.:..:..:.::|.||.|...:|..||:
 Frog     3 SSAKPFGN-QQYQALKKECQSKKVLFEDPVFPANNDALFYKTQRVQGVQWKRPKEFCTDPHLFVD 66

  Fly   144 GYSRFDVQQGELGDCWLLAATANLTQESNLFFRVIP--AEQSF----EENYAGIFHFRFWQYGKW 202
            |.|..|:.||::|:||.:||.::|.....|:.:|||  .||.:    .:.|||||||.||::|:|
 Frog    67 GISSHDLHQGQVGNCWFIAACSSLASREQLWQKVIPDWKEQEWYADKPQIYAGIFHFHFWKFGEW 131

  Fly   203 VDVIIDDRLPTYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCEAMEDFTGGVSEW 267
            |||:|||||||.|.:|:|.||.||||.|.||:|||||||.|.||||.||:|.:|:.||||||||.
 Frog   132 VDVVIDDRLPTINNQLIYCHSNEKNELWCALVEKAYAKLAGCYEALDGGNTADALVDFTGGVSEP 196

  Fly   268 YDLKEA--------PGNLFTILQKAAERNSMMGCSIE-PDPNVTEAETPQGLIRGHAYSITKVCL 323
            .:|.|.        ..:||..:.|...|..::.|||. ...:..||....||::||||::|.|..
 Frog   197 IELTEGHFVTDVEKRNDLFERVLKVHNRGGLISCSIRATSASDMEARMACGLVKGHAYAVTDVRK 261

  Fly   324 I----DIVTPNRQGKIPMIRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFDRDGEFWM 384
            :    .::...:..|:.||||||||| |.||||||||||.||:.:.:.::.::|:|.:.||||||
 Frog   262 VRLGHGLLAFFKSEKLEMIRMRNPWG-EREWNGPWSDSSEEWQKVSKSEREKLGVTVEDDGEFWM 325

  Fly   385 SFQDFLNHFDRVEICNLSPDSLTEDQQNSGKRKWEMSMYEGEWTPGV-----TAGGCRNFLDTFW 444
            :|:||..::..:.:|.|...|..     |..:.||.::....|....     .:|||.||..|:.
 Frog   326 TFEDFCKYYTDIIMCRLINTSYL-----SIHKTWEEAVLRSSWVQHQDPLQNRSGGCLNFKATYL 385

  Fly   445 HNPQYIITLVDPDEEDEEGQCTVIVALMQKNRRSKRNMG-MECLTIGFAIYSLNDRELENRPQGL 508
            .|||::..:..|::|       |:|.|.||.:|:.|..| .|.|.|||.|:.:   ||..|    
 Frog   386 QNPQFVFDVKKPEDE-------VLVCLQQKTKRTTRQEGKAENLAIGFEIHQV---ELNRR---- 436

  Fly   509 NFFRYKSSVGR--SPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETQNNMEEND 571
              ||..:...:  |..:||:|.|..|..|..|.|:|:|:||||...|||::|||::..:|..|. 
 Frog   437 --FRMHTLQPKVASSIYINSRCVFLRTDLKEGRYVIIPTTFDPGHTGEFLLRVFTDLPSNCCEL- 498

  Fly   572 DHVGYGGKADTITP-------GFP--TPKPIDPQKEGLRRLFDSIAGKDMEV------------- 614
                   |.|..|.       |:|  ..:......:||::. ||..|.|..|             
 Frog   499 -------KLDEPTKTCWSGLCGYPQLVSQVHVVSAQGLKQQ-DSNGGADPYVIISCEGNKVQSPV 555

  Fly   615 --DWMELK------------------RILDHS-MRDDLPKPVVFNRFSNNM----AFETQAAGPG 654
              |.::.|                  ::.:|: ::|:....||.:..:||:    :.|.|..|..
 Frog   556 IKDCLDPKFNVKGVFYRKKPGQPIVVQVWNHNVIKDEFMGLVVLSGDANNLQTQHSLELQDKGNK 620

  Fly   655 DDGAGACGLLSLI 667
            ..|. ..|.::|:
 Frog   621 KSGT-VSGTINLV 632

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CalpANP_001286613.1 Peptidase_C2 104..400 CDD:459889 143/314 (46%)
Calpain_III 416..569 CDD:238132 55/160 (34%)
EFh_PEF_CalpA_B 600..843 CDD:320071 20/106 (19%)
EF-hand motif 600..627 CDD:320071 9/60 (15%)
EF-hand motif 717..747 CDD:320071
EF-hand motif 748..778 CDD:320071
EF-hand motif 784..812 CDD:320071
EF-hand motif 813..843 CDD:320071
capn5NP_001006736.1 Peptidase_C2 27..341 CDD:459889 143/314 (46%)
Calpain_III 359..488 CDD:460050 50/144 (35%)
C2_Calpain 515..640 CDD:176011 22/120 (18%)
Blue background indicates that the domain is not in the aligned region.

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