Protein Alignment CalpA and capn2l

DIOPT Version :10

• Sequence 1: NP_001286613.1
• Gene: CalpA / 37232
• FlyBaseID: FBgn0012051
• Length: 843
• Species: Drosophila melanogaster
• Sequence 2: NP_001003485.2
• Gene: capn2l / 445091
• ZFINID: ZDB-GENE-050417-341
• Length: 700
• Species: Danio rerio
• Alignment Length: 773
• Identity: 320/773 - (41%)
• Similarity: 443/773 - (57%)
• Gaps: 130/773 - (16%)

  Fly    88 QDYETILNSCLASGSLFEDPLFPASNESLQFSR-RPD----RHIEWLRPHEIAENPQFFVEGYSR 147
            ||||.:...||.||.||:|.:|.|:..:|.|.. .|:    |.:|||||.::..||.|...|.:|
Zfish    30 QDYEALKRECLESGRLFQDGMFEANVSALGFKELGPNSSKVRGVEWLRPKQLTSNPTFISGGATR 94

  Fly   148 FDVQQGELGDCWLLAATANLTQESNLFFRVIPAEQSFEENYAGIFHFRFWQYGKWVDVIIDDRLP 212
            .|:.||.|||||||||.|:||...::|.||:||.|||:.:|||||||:|||:|:||||:||||||
Zfish    95 TDICQGALGDCWLLAAIASLTLNQDVFARVVPAGQSFDGDYAGIFHFQFWQFGEWVDVVIDDRLP 159

  Fly   213 TYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCEAMEDFTGGVSEWYDLKEAPGNL 277
            ...|||:::||.|.:||||||||||||||:|.||||.||:|.|..||||||::|.::|.:|..||
Zfish   160 ARKGELLFVHSAEGSEFWSALLEKAYAKLNGCYEALSGGTTTEGFEDFTGGIAEVHELPKAGPNL 224

  Fly   278 FTILQKAAERNSMMGCSIE-PDPNVTEAETPQGLIRGHAYSITKVCLIDIVTPNRQGKIPMIRMR 341
            |..:|||....|::||||: ...:.:||.|.|.|::|||||:|....::.    |.....:||:|
Zfish   225 FKTIQKALSWGSLLGCSIDITSSSDSEAITSQKLVKGHAYSVTGAEEVEY----RGDLTKLIRIR 285

  Fly   342 NPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFDRDGEFWMSFQDFLNHFDRVEICNLSPDSL 406
            |||| :.||.|||||.|.|||.|.:..:..:....: ||||||||.||:.|:.|||||||:||:|
Zfish   286 NPWG-QVEWTGPWSDGSSEWRQISDSDRERLSSKAE-DGEFWMSFSDFMRHYSRVEICNLTPDAL 348

  Fly   407 TEDQQNSGKRKWEMSMYEGEWTPGVTAGGCRNFLDTFWHNPQYIITLVDPDEE--DEEGQCTVIV 469
            |::..|    ||.:|.::|.|..|.|||||||:.::||.|||::|.|.:.|::  |.|..|:.:|
Zfish   349 TDESVN----KWALSKFDGNWRNGSTAGGCRNYPNSFWMNPQFLIKLEEQDDDPTDNEAGCSFVV 409

  Fly   470 ALMQKNRRSKRNMGMECLTIGFAIYSLNDRELENRPQGL--NFFRYKSSVGRSPHFINTREVCAR 532
            .|:|||||..|.:|.:..|||||||.:.|..:..|...|  |||...:|..||..|||.||||:|
Zfish   410 GLIQKNRRKMRKVGEDMNTIGFAIYEVPDEFVGQRNVHLDRNFFVRHASAARSETFINLREVCSR 474

  Fly   533 FKLPPGHYLIVPSTFDPNEEGEFIIRVFSETQNNMEENDDHVGYGGKADTITPGFPTPKPIDPQ- 596
            |.||||.||||||||:||::|:|.:|||||.|...:|.||                   |::.:
Zfish   475 FCLPPGEYLIVPSTFEPNKDGDFCVRVFSEKQAEFQELDD-------------------PVESKV 520

  Fly   597 -----KEG-----LRRLFDSIAGKDMEVDWMELKRILDH--SMRDDLPKPVVFNRFSNNMAFETQ 649
                 |||     .|.||..:||.|.|:...||::||::  :.|.|:
Zfish   521 AEIEIKEGDIDSRFRNLFKQLAGADSEISAFELQKILNNVIAKRKDI------------------ 567

  Fly   650 AAGPGDDGAGACGLLSLICGPFLKGTPFEEQLGMNDQSNKRLIGDNPADGGPVTANAIVDETHGF 714
                                                                        :|.||
Zfish   568 ------------------------------------------------------------KTDGF 572

  Fly   715 SKDVCRSMVAMLDADKSGKLGFEEFETLLSEIAKWKAIFKVYDVENTGRVSGFQLREALNSAGYH 779
            |.:.||:||.:||.|.:||||..||:.|.::|..:..::...|.:.:|.:|..::|||:..||:.
Zfish   573 SLETCRNMVNLLDKDGTGKLGLLEFKILWTKIELFVDVYSKNDKDQSGTMSSMEMREAVEKAGFS 637

  Fly   780 LNNRVLNVLGHRYGSRDGKIAFDDFIMCAVKIKTYIDIFKERDTEKNETATFTLEEWI 837
            |||.:..:|..||...:..|.||:|:.|.::::.....||..|.:||.|....:.||:
Zfish   638 LNNALHQILVARYSEPNLTIDFDNFVACLIRLECMFKAFKVLDKDKNGTVELNMMEWL 695

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CalpA	NP_001286613.1	Peptidase_C2	104..400	CDD:459889	157/301 (52%)
		Calpain_III	416..569	CDD:238132	80/156 (51%)
		EFh_PEF_CalpA_B	600..843	CDD:320071	59/240 (25%)
		EF-hand motif	600..627	CDD:320071	11/28 (39%)
		EF-hand motif	717..747	CDD:320071	14/29 (48%)
		EF-hand motif	748..778	CDD:320071	7/29 (24%)
		EF-hand motif	784..812	CDD:320071	8/27 (30%)
		EF-hand motif	813..843	CDD:320071	8/25 (32%)
capn2l	NP_001003485.2	None