DRSC/TRiP Functional Genomics Resources

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Protein Alignment CalpA and zgc:85932

DIOPT Version :10

Sequence 1:NP_001286613.1 Gene:CalpA / 37232 FlyBaseID:FBgn0012051 Length:843 Species:Drosophila melanogaster
Sequence 2:NP_998104.1 Gene:zgc:85932 / 405875 ZFINID:ZDB-GENE-040426-2460 Length:671 Species:Danio rerio


Alignment Length:786 Identity:238/786 - (30%)
Similarity:374/786 - (47%) Gaps:143/786 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    72 GNLGEKSSSLGPYSEVQDYETILNS----CLASGSLFEDPLFPASNESLQFSRRPDRHIEWLRPH 132
            |..|.|.    |.|...:..|.|.:    ..|:| |:.|..||..|..:|      ..:.|.||.
Zfish    15 GESGNKK----PQSTYSNPRTSLGAPAPPVPATG-LYVDTRFPVQNMPVQ------NDLVWRRPK 68

  Fly   133 EIAENPQFFVEGYSRFDVQQGELGDCWLLAATANLTQESNLFFRVIPAEQSFEENYAGIFHFRFW 197
            ||...|||.|:|.:|.|:.|..|||||.|:|.|:|:....|..||:||.|.|::.|.|.|.|:||
Zfish    69 EICLFPQFIVDGATRMDICQVVLGDCWFLSAVASLSLYPALLDRVVPAGQGFQQGYNGCFCFQFW 133

  Fly   198 QYGKWVDVIIDDRLPTYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCEAMEDFTG 262
            |||:|:.|.|||.|||.|.:|:|:||..::||||||||||||||.|.|.||..|...|||.|.||
Zfish   134 QYGEWISVKIDDLLPTCNNQLIYLHSASRDEFWSALLEKAYAKLKGGYSALNMGFPHEAMVDMTG 198

  Fly   263 GVSEWYDLKEAPGNLFTILQKAAERNSMMGCSIEPDPNVTEAETPQGLIRGHAYSITKVCLIDIV 327
            |::|.:.:...|..|.:.|:...|:.:::.|:....|  .|.....|::..||||:|.:..:   
Zfish   199 GITEVFMVASLPRALGSFLRSLLEKGALINCANSQGP--LEKSNEFGILFRHAYSVTALETV--- 258

  Fly   328 TPNRQGKIPMIRMRNPWGNEAEWNGPWSDSSP-EWRYIPEEQKAEIGLTFDRDGEFWMSFQDFLN 391
             .:..|.:.::|:||||| :|||.|||||... ||..:..|::..:......|||||||..||..
Zfish   259 -KSTIGPVQLVRIRNPWG-KAEWEGPWSDKKGIEWHMVTAEEQRRVQRIQQEDGEFWMSLADFRQ 321

  Fly   392 HFDRVEICNLSPDSLTEDQQNSGKRKWEMSMYEGEWTPGVTAGGCRNFLDTFWHNPQYIITLVDP 456
            :|:.:|:|:||.|:|:|   ...|:.|:.:.:.|:|||             ...:|||.:||::.
Zfish   322 NFELMEVCHLSEDTLSE---GDVKKPWKCTSHHGQWTP-------------LQGSPQYNLTLLEE 370

  Fly   457 DEE--DEEGQCTVIVALMQKNRRSKRNMGMECLTIGFAIYSLNDRELENRPQGLNFFRYKSSVGR 519
            |::  |.|..|:.::|||||:.|.:..:    |:|...||...|..:.:|...|      .|..:
Zfish   371 DDDPSDPELTCSFLLALMQKHTRQRGTL----LSIALHIYKARDHGVSSRESPL------LSTTK 425

  Fly   520 SPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETQNNMEENDDHVGYGGKADTIT 584
            ...|....|:..|.:|.||||:|:|:..:.|:.|||::||.:|..|.....:   ..|...|::|
Zfish   426 DQGFQQRPELVLRSRLAPGHYIIIPAIQETNQSGEFLLRVLTEKGNTTTAAE---RAGVATDSLT 487

  Fly   585 PGFPTPKPIDPQKEGL------RRLFDSIAGKDMEVDWMELKRILDHSMRDDLPKPV-VFNRFSN 642
                  :|:.|:..||      |.||                  :.|..:....:|: ::|..  
Zfish   488 ------QPLSPRLTGLPSTNEARDLF------------------VKHCAKGPYCRPLDLYNLL-- 526

  Fly   643 NMAFETQAAGPGDDGAGACGLLSLICGPFLKGTPFEEQLGMNDQSNKRLIGDNPADGGPVTANAI 707
                 |:|...| ..||:..:|||                                         
Zfish   527 -----TEAISKG-VFAGSEKMLSL----------------------------------------- 544

  Fly   708 VDETHGFSKDVCRSMVAMLDADKSGKLGFEEFETLLSEIAKWKAIFKVYDVENTGRVSGFQLREA 772
                     :.|:|.|.::|:...|:|...||:.|..::.||.:||..:|......:...::..|
Zfish   545 ---------EHCKSFVVLMDSQGMGRLDLTEFQALWDKLRKWTSIFITFDKNKNQALDYLEISPA 600

  Fly   773 LNSAGYHLNNRVLNVLGHRYGSRDGKIAFDDFIMCAVKIKTYIDIFKERDTEKNETATFTLEEWI 837
            |::||..::..:|.::..||...|..::|..|:...:|:...:..|:..|.......:....:::
Zfish   601 LSAAGIKVDEFILQLISLRYTEPDMTLSFPGFLFLLMKLDCMMRKFQSFDVTGTGMISVNCRQFL 665

  Fly   838 ERTIYS 843
            ..|:|:
Zfish   666 HMTMYN 671

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CalpANP_001286613.1 Peptidase_C2 104..400 CDD:459889 125/296 (42%)
Calpain_III 416..569 CDD:238132 46/154 (30%)
EFh_PEF_CalpA_B 600..843 CDD:320071 43/249 (17%)
EF-hand motif 600..627 CDD:320071 5/32 (16%)
EF-hand motif 717..747 CDD:320071 9/29 (31%)
EF-hand motif 748..778 CDD:320071 8/29 (28%)
EF-hand motif 784..812 CDD:320071 7/27 (26%)
EF-hand motif 813..843 CDD:320071 3/29 (10%)
zgc:85932NP_998104.1 Peptidase_C2 46..330 CDD:459889 125/296 (42%)
Calpain_III 343..475 CDD:469636 46/154 (30%)
EFh_PEF_CAPN13_14 502..671 CDD:320070 42/244 (17%)
EF-hand motif 502..530 CDD:320070 7/52 (13%)
EF-hand motif 546..575 CDD:320070 9/28 (32%)
EF-hand motif 576..606 CDD:320070 8/29 (28%)
EF-hand motif 612..640 CDD:320070 7/27 (26%)
EF-hand motif 642..671 CDD:320070 3/28 (11%)

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