DRSC/TRiP Functional Genomics Resources

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Protein Alignment CalpA and capn1a

DIOPT Version :10

Sequence 1:NP_001286613.1 Gene:CalpA / 37232 FlyBaseID:FBgn0012051 Length:843 Species:Drosophila melanogaster
Sequence 2:XP_068081046.1 Gene:capn1a / 393417 ZFINID:ZDB-GENE-040426-1263 Length:705 Species:Danio rerio


Alignment Length:801 Identity:336/801 - (41%)
Similarity:459/801 - (57%) Gaps:131/801 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    71 YGNLGE-------KSSSLGPYSEV-----QDYETILNSCLASGSLFEDPLFPASNESLQFSR--- 120
            ||.:..       |:...|.:.:.     ||||.:...||..|.|||||.|||...||.|..   
Zfish     4 YGGISAHISANRLKADGAGSFEQALHFQNQDYEALRQECLEGGYLFEDPCFPAEPPSLGFKELAP 68

  Fly   121 --RPDRHIEWLRPHEIAENPQFFVEGYSRFDVQQGELGDCWLLAATANLTQESNLFFRVIPAEQS 183
              ...|.:||:||.|:.::|||.|.|.:|.|:.||.|||||||||..:||....|..||:|..||
Zfish    69 HSSKTRDVEWMRPTELCDDPQFIVGGATRTDICQGALGDCWLLAAIGSLTLNERLLHRVVPHGQS 133

  Fly   184 FEENYAGIFHFRFWQYGKWVDVIIDDRLPTYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEAL 248
            |:::|||||||:|||:|:||||:||||||..:||||::||.|.|||||||:|||||||:||||||
Zfish   134 FQDDYAGIFHFQFWQFGEWVDVVIDDRLPVKDGELMFVHSAEGNEFWSALVEKAYAKLNGSYEAL 198

  Fly   249 KGGSTCEAMEDFTGGVSEWYDLKEAPGNLFTILQKAAERNSMMGCSIEPDPNVT-----EAETPQ 308
            .||||.|..|||||||||.|:|::||.:|:.|:.||.:|.|::||||:    :|     |:.|.:
Zfish   199 SGGSTTEGFEDFTGGVSEMYELRKAPRDLYRIISKALDRGSLLGCSID----ITSAFDMESVTFK 259

  Fly   309 GLIRGHAYSITKVCLIDIVTPNRQGKIP-MIRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEI 372
            .|::|||||:|.:..::.     :|::. :||:||||| :.||.|.|||:||||..|...:|.::
Zfish   260 KLVKGHAYSVTALKQVEY-----RGRMERLIRIRNPWG-QVEWTGAWSDNSPEWDEIDPSEKDDL 318

  Fly   373 GLTFDRDGEFWMSFQDFLNHFDRVEICNLSPDSLTEDQQNSGKRKWEMSMYEGEWTPGVTAGGCR 437
            .|..: ||||||||.:||..|.|:|||||:||:|::|..:    .|....:.|.|..|.||||||
Zfish   319 HLQME-DGEFWMSFGEFLRQFSRLEICNLTPDALSDDDMS----HWNTIKFHGAWRRGSTAGGCR 378

  Fly   438 NFLDTFWHNPQYIITLV--DPDEEDEEGQCTVIVALMQKNRRSKRNMGMECLTIGFAIYSLNDR- 499
            |..:|||.||||.|||:  |.|.||||..|:.:||||||:||..|..|.:..|||||||.:..: 
Zfish   379 NHPNTFWINPQYKITLLEEDDDPEDEEVACSFLVALMQKDRRRYRRHGQDMHTIGFAIYEVRSQW 443

  Fly   500 --ELENRPQGLNFFRYKSSVGRSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSE 562
              ..:|.....:||...||..||..|||.|||..|.:||||.|:||||||:|::|.:|::|||:|
Zfish   444 YTGCQNVHLKKDFFLSNSSAARSETFINLREVSTRLRLPPGEYIIVPSTFEPSKEADFVLRVFTE 508

  Fly   563 TQNNMEENDDHVGYGGKADTITPGFPTPKPIDPQKEGLRRLFDSIAGKDMEVDWMELKRILDH-- 625
            .|:..||.||.:    .||.......|...||   :..:.||..:||:|||:...|||.||:.  
Zfish   509 KQSETEELDDEI----SADLEDEEEITEDDID---DSFKSLFAQLAGEDMEISVHELKTILNRVV 566

  Fly   626 SMRDDLPKPVVFNRFSNNMAFETQAAGPGDDGAGACGLLSLICGPFLKGTPFEEQLGMNDQSNKR 690
            |...|:                                                           
Zfish   567 SKHKDV----------------------------------------------------------- 572

  Fly   691 LIGDNPADGGPVTANAIVDETHGFSKDVCRSMVAMLDADKSGKLGFEEFETLLSEIAKWKAIFKV 755
                               :|.|||.|.||:||.:||.|.|.:||..||:.|.::|.|...||:.
Zfish   573 -------------------KTDGFSMDSCRTMVNLLDKDGSARLGLVEFQILWNKIRKLLGIFRE 618

  Fly   756 YDVENTGRVSGFQLREALNSAGYHLNNRVLNVLGHRYGSRDGKIAFDDFIMCAVKIKTYIDIFKE 820
            :|::.:|.:|.:::|.|:.|||:.||||:..:|..||...:. |.||:|:.|.:|::.....|::
Zfish   619 FDIDKSGTMSSYEMRLAVESAGFKLNNRLNQILVARYAENEA-IDFDNFVCCLIKLEAMFRSFQQ 682

  Fly   821 RDTEKNETATFTLEEWIERTI 841
            .|.|:..||...|.||:..|:
Zfish   683 LDREETGTAEMNLSEWLFMTM 703

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CalpANP_001286613.1 Peptidase_C2 104..400 CDD:459889 164/306 (54%)
Calpain_III 416..569 CDD:238132 78/157 (50%)
EFh_PEF_CalpA_B 600..843 CDD:320071 66/244 (27%)
EF-hand motif 600..627 CDD:320071 12/28 (43%)
EF-hand motif 717..747 CDD:320071 14/29 (48%)
EF-hand motif 748..778 CDD:320071 10/29 (34%)
EF-hand motif 784..812 CDD:320071 9/27 (33%)
EF-hand motif 813..843 CDD:320071 9/29 (31%)
capn1aXP_068081046.1 Peptidase_C2 49..345 CDD:459889 164/306 (54%)
Calpain_III 358..516 CDD:238132 79/157 (50%)
EFh_PEF_CAPN1 538..705 CDD:320073 66/245 (27%)
EF-hand motif 538..566 CDD:320073 12/27 (44%)
EF-hand motif 581..610 CDD:320073 13/28 (46%)
EF-hand motif 611..641 CDD:320073 10/29 (34%)
EF-hand motif 647..674 CDD:320073 9/27 (33%)
EF-hand motif 676..705 CDD:320073 9/28 (32%)

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