Protein Alignment CalpA and CalpC

DIOPT Version :10

• Sequence 1: NP_001286613.1
• Gene: CalpA / 37232
• FlyBaseID: FBgn0012051
• Length: 843
• Species: Drosophila melanogaster
• Sequence 2: NP_573118.2
• Gene: CalpC / 32597
• FlyBaseID: FBgn0260450
• Length: 681
• Species: Drosophila melanogaster
• Alignment Length: 806
• Identity: 220/806 - (27%)
• Similarity: 361/806 - (44%)
• Gaps: 191/806 - (23%)

  Fly    90 YETILNSCLASGSLFEDPLFPASNESLQFSRRPDRHIEWLRPHEIAEN------------PQFFV 142
            ||.||:.|.:...|:|||.|||...|:.:.:.|....:|.|..::|::            |.|..
  Fly     5 YERILSDCRSKNVLWEDPDFPAVQSSVFYYQTPPFTFQWKRIMDLADSGSGAVAANSSAAPVFLN 69

  Fly   143 EGYSRFDVQQGELGDCWLLAATANLTQESNLFFRVIPAEQSFEENYAGIFHFRFWQYGKWVDVII 207
            |. :.|||..|::||.||::....|:...|||:||:||:|:....: |:|.||.|..|:||:|::
  Fly    70 ES-AEFDVVPGKMGDRWLVSCLGLLSSLRNLFYRVVPADQTLASAH-GVFRFRLWWCGEWVEVLV 132

  Fly   208 DDRLPTYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCEAMEDFTGGVSEWYDLKE 272
            ||||||.||.|.:|.....|.||:||||||.|||||||||||.|:..:.:.|..|||     :::
  Fly   133 DDRLPTINGRLAFMQPQASNCFWAALLEKAIAKLHGSYEALKYGTRSDGLTDLLGGV-----VRQ 192

  Fly   273 AP---GNLF-TILQKAAERNSMMGCSIEPDPNVTE---AE-TPQGLIRGHAY------------- 316
            .|   .|:. ..|::......::.|..:....|.:   || .|.|::....|
  Fly   193 MPILSDNIRPQTLKELLTTTCIVTCLADKSATVAKKNLAERMPNGILVNVNYRLSSLDKVKTLMG 257

  Fly   317 -SITKVCLIDIVTPNRQGKIPMIRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKA----EIGLTF 376
             |:..|||.|..:            ..|:|.:..:.|.||..|..|..:.:.::|    ::|
  Fly   258 DSVQLVCLKDTFS------------SKPFGEKTHFLGDWSPMSKTWERVSQVERARLIRQLG--- 307

  Fly   377 DRDGEFWMSFQDFLNHFDRVEICNLSPD-SLTEDQQNSGKRKWEMSMYEGEWTPGVTAGGCRNFL 440
              .||||:||.||:..|..:|:..|..: |..|:...|....|:|.|::|:|..|||||||||.
  Fly   308 --PGEFWLSFCDFVEIFSTMEVVYLDTETSNDEEMLKSRPLHWKMKMHQGQWKRGVTAGGCRNH- 369

  Fly   441 DTFWHNPQYIITLVDPDEEDEEGQCTVIVALMQKNRRSKRNMGMECLTIGFAIYSLNDRELENRP 505
            ::|..|||.:|::  .||:|      :::||.|       :..:|...|||.:|:.:...:.:..
  Fly   370 ESFHINPQLLISV--QDEQD------LVIALNQ-------HTAVEPKVIGFTMYTWDGEYMLSEC 419

  Fly   506 QGLNFFRYKSSVGRSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFS--------- 561
            ...:||:...|...| .:.|||.|.....|..|||:::|:|::|.||..|.:|:..
  Fly   420 LQKDFFKNHVSYLNS-DYGNTRHVSYHTHLEAGHYVLIPTTYEPAEEAHFTVRILGTGSFRLSCL 483

  Fly   562 ETQNNMEENDDHVGYGGKADTITPGFPTPKPIDPQKEG---------LRRLFDSIAGKDMEVDWM 617
            |||..:               :...||..|..|.::.|         ...::..:|.::..::..
  Fly   484 ETQTMI---------------LLDPFPALKSTDAERCGGPKVKSVCQYEPVYMQLADENKTINCF 533

  Fly   618 ELKRILDHSMRDDLPKPVVFNRFSNNMAFETQAAGPGDDGAGACGLLSLICGPFLKGTPFEEQLG 682
            ||..:|:..:.:|                                        ::||
  Fly   534 ELHELLEACLPND----------------------------------------YIKG-------- 550

  Fly   683 MNDQSNKRLIGDNPADGGPVTANAIVDETHGFSKDVCRSMVAMLDADKSGKLGFEEFETLLSEIA 747
                                .||.          |:||.::|:.|...||::.|::|:|.:..:.
  Fly   551 --------------------CANI----------DICRQVIALQDRSGSGRITFQQFKTFMVNLK 585

  Fly   748 KWKAIFKVYDVENTGRVSGFQLREALNSAGYHLNNRVLNVLGHRYGSRDGKIAFDDFIMCAVKIK 812
            .|:.:||:|..|..|.:...:||:||...|:.|:..::|.|..||..:||.:...||:...:.:.
  Fly   586 SWQGVFKMYTKEKAGILRAERLRDALCDIGFQLSTDIMNCLIQRYIRKDGTLRLSDFVSAVIHLT 650

  Fly   813 TYIDIFKERDTEKNETATFTLEEWIE 838
            |..:.|..::..:.......|.:||:
  Fly   651 TAFNQFHLKNYGQVNVIEVHLHDWIK 676

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CalpA	NP_001286613.1	Peptidase_C2	104..400	CDD:459889	109/333 (33%)
		Calpain_III	416..569	CDD:238132	52/161 (32%)
		EFh_PEF_CalpA_B	600..843	CDD:320071	44/239 (18%)
		EF-hand motif	600..627	CDD:320071	4/26 (15%)
		EF-hand motif	717..747	CDD:320071	10/29 (34%)
		EF-hand motif	748..778	CDD:320071	10/29 (34%)
		EF-hand motif	784..812	CDD:320071	8/27 (30%)
		EF-hand motif	813..843	CDD:320071	5/26 (19%)
CalpC	NP_573118.2	CysPc	7..329	CDD:238004	113/345 (33%)
		Calpain_III	346..483	CDD:238132	49/153 (32%)
		EFh_PEF	515..680	CDD:355382	44/240 (18%)
		EF-hand motif	515..543	CDD:320054	4/27 (15%)
		EF-hand motif	556..585	CDD:320054	9/28 (32%)
		EF-hand motif	586..615	CDD:320054	10/28 (36%)
		EF-hand motif	622..650	CDD:320054	8/27 (30%)
		EF-hand motif	652..680	CDD:320054	4/25 (16%)