DRSC/TRiP Functional Genomics Resources

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Protein Alignment CalpA and Capn7

DIOPT Version :10

Sequence 1:NP_001286613.1 Gene:CalpA / 37232 FlyBaseID:FBgn0012051 Length:843 Species:Drosophila melanogaster
Sequence 2:NP_001025208.1 Gene:Capn7 / 306260 RGDID:1304855 Length:813 Species:Rattus norvegicus


Alignment Length:637 Identity:134/637 - (21%)
Similarity:219/637 - (34%) Gaps:255/637 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly    97 CLASGSLFEDPLFPASNESLQFSRRPDRHIEWLRPHEIAENPQFFVEGYSRFDVQQGELGDCWLL 161
            |...|.|   ||.|  .:...||:       |:||.::..||. .:...|.|.::|..:.||..:
  Rat   242 CDRLGKL---PLSP--KQKATFSK-------WVRPEDLTNNPT-MIYTVSSFSIKQTIVSDCSFV 293

  Fly   162 AATANLTQESNLFFR------VIPAEQSFEENY--AGIFHFRFWQYGKWVDVIIDDRLPT-YNGE 217
            |:.|........|.:      :.|..:..|..|  .|.:..:....|....|||||:||. :.||
  Rat   294 ASLAISAAYERRFNKKLITSIIYPQNKDGEPEYNPCGKYMVKLHLNGVPRKVIIDDQLPVDHKGE 358

  Fly   218 LMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCEAMEDFTGGVSEWYDLKE-----APGNL 277
            |:..:|..|:|.|.:|:||||.|:.|.|: ..|.::...:...||.:.|...:..     :..:.
  Rat   359 LLCSYSNNKSELWVSLIEKAYMKVMGGYD-FPGSNSNIDLHALTGWIPERIAMHSDSQTFSKDSS 422

  Fly   278 FTILQKAAERNSMM-----GCSIEPDPNVTEAETPQ-GLIRGHAYSITKVCLIDIVTPNRQGK-I 335
            |.:|.:...:..::     |.       :||||..: ||:..|||::     :||    |:.| :
  Rat   423 FRMLYQRFHKGDVLITASTGM-------MTEAEGEKWGLVPTHAYAV-----LDI----REFKGL 471

  Fly   336 PMIRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFD-------RDGEFWMSFQDFLNHF 393
            ..|:::||| :...|.|.:|::..: .:.||.||.   |.||       .:|.||:|:.|...::
  Rat   472 RFIQLKNPW-SHLRWKGRYSENDVK-NWTPELQKY---LNFDPRTAQKIDNGIFWISWDDLCQYY 531

  Fly   394 DRV------------------------------EICNLSPDSLTEDQ------------------ 410
            |.|                              .:.| :|....|.|                  
  Rat   532 DVVYLSWNPALFKESTCIHSTWDAKQGPVKDAYSLAN-NPQYKLEVQCPQGGAAVWVLLSRHITD 595

  Fly   411 ----------------QNSGKRKW-----------------------------------EMSMYE 424
                            :..||:.:                                   .:|.||
  Rat   596 KDDFANNREFITMVVYKTDGKKVYYPADPAPYIDGIRINSPHYLTKIKLTTPGTHTFTLVVSQYE 660

  Fly   425 ---------------------------------GEWTPGVTAGGCRNFLDTFWHNPQYIITLVDP 456
                                             |:|: |.:||||.||.:|..:||.|...:   
  Rat   661 KQNTIHYTVRVYSACSFTFSKIPSPYTLSKRINGKWS-GQSAGGCGNFQETHKNNPIYQFHI--- 721

  Fly   457 DEEDEEGQCTVIVALMQKNRRSKRNMGMECLTI---------GFAIYSLND-------RELENRP 505
               |:.|.     .|::.....:.::|.|.:.:         ||...|..|       .||||  
  Rat   722 ---DKTGP-----LLIELRGPRQYSVGFEVVAVSIAGDPGPHGFQRKSSGDYRCGFCYLELEN-- 776

  Fly   506 QGLNFFRYKSSVGRSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFII 557
                                         :|.|.:.::||||.|.:||.|.:
  Rat   777 -----------------------------IPAGIFNVIPSTFLPKQEGPFFL 799

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CalpANP_001286613.1 Peptidase_C2 104..400 CDD:459889 86/353 (24%)
Calpain_III 416..569 CDD:238132 39/226 (17%)
EFh_PEF_CalpA_B 600..843 CDD:320071
EF-hand motif 600..627 CDD:320071
EF-hand motif 717..747 CDD:320071
EF-hand motif 748..778 CDD:320071
EF-hand motif 784..812 CDD:320071
EF-hand motif 813..843 CDD:320071
Capn7NP_001025208.1 MIT_calpain7_1 5..76 CDD:239144
MIT 85..157 CDD:469712
CysPc 214..538 CDD:238004 89/330 (27%)
calpain_III 687..810 CDD:214786 36/156 (23%)
Blue background indicates that the domain is not in the aligned region.

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