DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CalpA and Capn2

DIOPT Version :10

Sequence 1:NP_001286613.1 Gene:CalpA / 37232 FlyBaseID:FBgn0012051 Length:843 Species:Drosophila melanogaster
Sequence 2:NP_058812.1 Gene:Capn2 / 29154 RGDID:2268 Length:700 Species:Rattus norvegicus


Alignment Length:793 Identity:327/793 - (41%)
Similarity:461/793 - (58%) Gaps:133/793 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    76 EKSSSLGPYSEV-----QDYETILNSCLASGSLFEDPLFPASNESLQFSR-----RPDRHIEWLR 130
            |.:..||.:...     |||||:.|.||.:|:||:||.|||...||.|..     ...|.|||.|
  Rat    13 EAAEGLGSHERAIKYLNQDYETLRNECLEAGALFQDPSFPALPSSLGFKELGPYSSKTRGIEWKR 77

  Fly   131 PHEIAENPQFFVEGYSRFDVQQGELGDCWLLAATANLTQESNLFFRVIPAEQSFEENYAGIFHFR 195
            |.||..:|||.:.|.:|.|:.||.|||||||||.|:||....:..||:|.:|||:|||||||||:
  Rat    78 PTEICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPLDQSFQENYAGIFHFQ 142

  Fly   196 FWQYGKWVDVIIDDRLPTYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCEAMEDF 260
            |||||:||:|::||||||.:|||:::||.|.:|||||||||||||::|.||||.||:|.|..|||
  Rat   143 FWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGATTEGFEDF 207

  Fly   261 TGGVSEWYDLKEAPGNLFTILQKAAERNSMMGCSIEPDPNVT-----EAETPQGLIRGHAYSITK 320
            |||::|||:|::.|.|||.|:|||.|:.|::||||:    :|     ||.|.|.|::|||||:|.
  Rat   208 TGGIAEWYELRKPPPNLFKIIQKALEKGSLLGCSID----ITSAADSEAVTYQKLVKGHAYSVTG 268

  Fly   321 VCLIDIVTPNRQGKI-PMIRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFDRDGEFWM 384
            ...::     ..|.: .:||:||||| :.||.|.|:|:.|.|..:..|.:|.: .....||||||
  Rat   269 AEEVE-----SSGSLQKLIRIRNPWG-QVEWTGKWNDNCPSWNTVDPEVRANL-TERQEDGEFWM 326

  Fly   385 SFQDFLNHFDRVEICNLSPDSLTEDQQNSGKRKWEMSMYEGEWTPGVTAGGCRNFLDTFWHNPQY 449
            ||.|||.|:.|:|||||:||:||.|..    :||:::..:|.|..|.|||||||:.:|||.||||
  Rat   327 SFSDFLRHYSRLEICNLTPDTLTCDSY----KKWKLTKMDGNWRRGSTAGGCRNYPNTFWMNPQY 387

  Fly   450 IITLVDPDEEDEEGQ--CTVIVALMQKNRRSKRNMGMECLTIGFAIYSLNDRELENRPQ---GLN 509
            :|.|.:.||:||:|:  ||.:|.|:||:||.:|.||.:..||||.||.:.: ||..:..   ..|
  Rat   388 LIKLEEEDEDDEDGERGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPE-ELTGQTNIHLSKN 451

  Fly   510 FFRYKSSVGRSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETQNNMEENDDHV 574
            ||....:..||..|||.|||..|||||||.|::|||||:|::.|:|.||||||.:.:.:..||.:
  Rat   452 FFLTTRARERSDTFINLREVLNRFKLPPGEYVLVPSTFEPHKNGDFCIRVFSEKKADYQTVDDEI 516

  Fly   575 GYGGKADTITPGFPTPKPIDPQKE----GLRRLFDSIAGKDMEVDWMELKRILDH--SMRDDLPK 633
                :|:.        :.|:..:|    |.||||..:||:|.|:...||:.||..  :.|:|:  
  Rat   517 ----EANI--------EEIEANEEDIGDGFRRLFAQLAGEDAEISAFELQTILRRVLAKREDI-- 567

  Fly   634 PVVFNRFSNNMAFETQAAGPGDDGAGACGLLSLICGPFLKGTPFEEQLGMNDQSNKRLIGDNPAD 698
                                                                             
  Rat   568 ----------------------------------------------------------------- 567

  Fly   699 GGPVTANAIVDETHGFSKDVCRSMVAMLDADKSGKLGFEEFETLLSEIAKWKAIFKVYDVENTGR 763
                       ::.|||.:.|:.||.|||.|.|||||.:||..|.::|.|::.|::..||:.:|.
  Rat   568 -----------KSDGFSIETCKIMVDMLDEDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRSGT 621

  Fly   764 VSGFQLREALNSAGYHLNNRVLNVLGHRYGSRDGKIAFDDFIMCAVKIKTYIDIFKERDTEKNET 828
            ::.:::|:||..||:.|..::..|:..|:...:..|.||:|:.|.|:::....|||:.|.|...|
  Rat   622 MNSYEMRKALEEAGFKLPCQLHQVIVARFADDELIIDFDNFVRCLVRLEILFKIFKQLDPENTGT 686

  Fly   829 ATFTLEEWIERTI 841
            ....|..|:..::
  Rat   687 IQLDLISWLSFSV 699

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CalpANP_001286613.1 Peptidase_C2 104..400 CDD:459889 162/306 (53%)
Calpain_III 416..569 CDD:238132 78/157 (50%)
EFh_PEF_CalpA_B 600..843 CDD:320071 60/244 (25%)
EF-hand motif 600..627 CDD:320071 12/28 (43%)
EF-hand motif 717..747 CDD:320071 15/29 (52%)
EF-hand motif 748..778 CDD:320071 9/29 (31%)
EF-hand motif 784..812 CDD:320071 8/27 (30%)
EF-hand motif 813..843 CDD:320071 8/29 (28%)
Capn2NP_058812.1 Peptidase_C2 46..342 CDD:459889 162/306 (53%)
Domain III 345..514 83/173 (48%)
Calpain_III 354..510 CDD:238132 78/156 (50%)
Linker 515..529 2/25 (8%)
Domain IV 530..700 61/248 (25%)
EFh_PEF_CAPN2 533..700 CDD:320074 61/245 (25%)
EF-hand motif 533..561 CDD:320074 13/27 (48%)
EF-hand motif 576..605 CDD:320074 15/28 (54%)
EF-hand motif 606..636 CDD:320074 9/29 (31%)
EF-hand motif 642..670 CDD:320074 8/27 (30%)
EF-hand motif 672..700 CDD:320074 8/28 (29%)

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