DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CalpA and Capn11

DIOPT Version :10

Sequence 1:NP_001286613.1 Gene:CalpA / 37232 FlyBaseID:FBgn0012051 Length:843 Species:Drosophila melanogaster
Sequence 2:XP_011244781.1 Gene:Capn11 / 268958 MGIID:1352490 Length:753 Species:Mus musculus


Alignment Length:863 Identity:324/863 - (37%)
Similarity:466/863 - (53%) Gaps:158/863 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 DLRGFLR-QAGQEFLNAAGEAAMGAAKDVVGSVINEIFIKKEADTKRVLPSIKNMRVQPLQSQSN 66
            :|.|.|. .|.:|||..|......|.|.:| :.||...:|.:.                 ..|..
Mouse    25 ELMGLLALSACEEFLTGAWMDISWAEKGMV-ATINHSRLKDKG-----------------VGQHQ 71

  Fly    67 STLYYGNLGEKSSSLGPYSEVQDYETILNSCLASGSLFEDPLFPASNESLQFSR-RPD----RHI 126
            :...|.|              |:||.:...||..|.|||||.|||...|:.... .|:    ::|
Mouse    72 NAYNYKN--------------QNYEDLRAECLRKGELFEDPFFPAEPRSIGVKNLGPNSEHMQNI 122

  Fly   127 EWLRPHEIAENPQFFVEGYSRFDVQQGELGDCWLLAATANLTQESNLFFRVIPAEQSFEENYAGI 191
            .|.||.:|..||||....:|..|:.||.|||||||||..:||....|.:||:|..|||::|||||
Mouse   123 YWQRPKDIIHNPQFITNDFSPTDICQGILGDCWLLAAIGSLTTCPKLLYRVVPRNQSFKKNYAGI 187

  Fly   192 FHFRFWQYGKWVDVIIDDRLPTYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCEA 256
            |||:.||:|.|::|::||||||.|.:|:::|::.:.:|||||||||||||.|||.||.||||.|.
Mouse   188 FHFQLWQFGHWLNVVVDDRLPTRNNKLVFVHASHRQDFWSALLEKAYAKLIGSYGALSGGSTLEG 252

  Fly   257 MEDFTGGVSEWYDLKEAPGNLFTILQKAAERNSMMGCSIE-PDPNVTEAETPQGLIRGHAYSITK 320
            :|||||||::...|::.|||:..:|:||.|::|:|||||| .|.:..|..|...|:|||||::|.
Mouse   253 LEDFTGGVAQCIPLQKPPGNMLRLLKKALEKSSLMGCSIEVTDNSEVETMTHNMLVRGHAYAVTG 317

  Fly   321 VCLIDIVTPNRQGKIPMIRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFDRDGEFWMS 385
              |.|:.  .|.....:||::|||| ..||||.|||.:.||..:..:.:.:: |....||:||||
Mouse   318 --LEDVY--YRDKLETLIRIQNPWG-RVEWNGAWSDKATEWEEVSPDVRVQL-LHKKDDGDFWMS 376

  Fly   386 FQDFLNHFDRVEICNLSPDSL-TEDQQNSGKRKWEMSMYEGEWTPGVTAGGCRNFLDTFWHNPQY 449
            ::||:::|..:|||||:||:| |.|.    |.:|..:.|||.|..|.|||||||..:|||.|||:
Mouse   377 YEDFMSNFTLLEICNLTPDALNTWDY----KSRWHSTFYEGSWRRGSTAGGCRNHPETFWSNPQF 437

  Fly   450 IITLV---DPDEEDEEGQ--CTVIVALMQKNRRSKRNMGMECLTIGFAIYSLNDRELEN-RPQGL 508
            .|:|.   ||:::.|:.:  ||.:|||||||.|..|. |.:.|||||.|:|: .:|.:| |...|
Mouse   438 KISLPEVDDPEDDSEKNEMVCTCLVALMQKNWRHARE-GPQLLTIGFVIFSV-PKEFQNLRDIHL 500

  Fly   509 N---FFRYKSSVGRSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETQNNMEEN 570
            .   |.:|:.. |.|..|||:|||.:..:||||.|:|:|||::|:::.:|::|||:|..:.....
Mouse   501 KKDFFLKYRDH-GFSEIFINSREVNSHLRLPPGEYVIIPSTYEPHKDADFLLRVFTEKHSETWLL 564

  Fly   571 DD-----HVGYGGKADTITPGFPTPKPIDPQKEGLRRLFDSIAGKDMEVDWMELKRILDHSMRDD 630
            ||     |:    :.:|:     |.|.:|  |:.| :||..:|.:|.|||...|.::|       
Mouse   565 DDANRFEHL----QEETV-----TDKDLD--KDSL-QLFKIMANEDGEVDMYALHKLL------- 610

  Fly   631 LPKPVVFNRFSNNMAFETQAAGPGDDGAGACGLLSLICGPFLKGTPFEEQLGMNDQSNKRLIGDN 695
                   ||                                                        
Mouse   611 -------NR-------------------------------------------------------- 612

  Fly   696 PADGGPVTANAIVDETHGFSKDVCRSMVAMLDADKSGKLGFEEFETLLSEIAKWKAIFKVYDVEN 760
                  :||.....:|.|||.:|||.|:.:||.|.||||...||:.|..:|.||..|||..|.:.
Mouse   613 ------MTAKLRNFKTKGFSLEVCRRMINLLDKDGSGKLELHEFQVLWKKIKKWTEIFKECDEDR 671

  Fly   761 TGRVSGFQLREALNSAGYHLNNRVLNVLGHRYGSRDGKIA-FDDFIMCAVKIKTYIDIFKERDTE 824
            :|.::.:::|.|:..||..:||||..|:..||.  |..|. ||.|:.|.:::|.....|...||:
Mouse   672 SGNLNSYEMRLAIEKAGIKMNNRVTEVVVARYS--DNMIVDFDSFLNCFLRLKAMFAFFLSMDTK 734

  Fly   825 KNETATFTLEEWIERTIY 842
            |..:....:.:|::.|::
Mouse   735 KTGSICLDINQWLQITMW 752

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CalpANP_001286613.1 Peptidase_C2 104..400 CDD:459889 147/301 (49%)
Calpain_III 416..569 CDD:238132 72/161 (45%)
EFh_PEF_CalpA_B 600..843 CDD:320071 64/244 (26%)
EF-hand motif 600..627 CDD:320071 10/26 (38%)
EF-hand motif 717..747 CDD:320071 14/29 (48%)
EF-hand motif 748..778 CDD:320071 10/29 (34%)
EF-hand motif 784..812 CDD:320071 10/28 (36%)
EF-hand motif 813..843 CDD:320071 6/30 (20%)
Capn11XP_011244781.1 Peptidase_C2 95..391 CDD:459889 147/301 (49%)
Calpain_III 405..564 CDD:238132 72/161 (45%)
EFh_PEF_CAPN11 586..753 CDD:320068 64/246 (26%)
EF-hand motif 586..614 CDD:320068 12/104 (12%)
EF-hand motif 629..658 CDD:320068 14/28 (50%)
EF-hand motif 659..689 CDD:320068 10/29 (34%)
EF-hand motif 695..722 CDD:320068 10/28 (36%)
EF-hand motif 723..753 CDD:320068 6/30 (20%)

Return to query results.
Submit another query.