DRSC/TRiP Functional Genomics Resources

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Protein Alignment CalpA and tra-3

DIOPT Version :10

Sequence 1:NP_001286613.1 Gene:CalpA / 37232 FlyBaseID:FBgn0012051 Length:843 Species:Drosophila melanogaster
Sequence 2:NP_502751.1 Gene:tra-3 / 178385 WormBaseID:WBGene00006606 Length:648 Species:Caenorhabditis elegans


Alignment Length:557 Identity:198/557 - (35%)
Similarity:295/557 - (52%) Gaps:93/557 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    63 SQSNSTLYYGNLGEKSSSLGPYSEVQDYETILNSCLASGSLFEDPLFPASNESLQFSRRPDRHIE 127
            ::|..|.::||              |:||.:...|:.....|.|.|||.:|:||...:|....|.
 Worm     2 TRSEKTRHFGN--------------QNYEKLRKICIKKKQPFVDTLFPPTNQSLFLEQRQSSDIV 52

  Fly   128 WLRPHEIAENPQFFVEGYSRFDVQQGELGDCWLLAATANLTQESNLFFRVIP----AEQSFEENY 188
            |.||.|:..:|..||||.|..||.||.||:||.::|.:.||....|..:|||    .|.|.:..|
 Worm    53 WKRPGELHPDPHLFVEGASPNDVTQGILGNCWFVSACSALTHNFKLLAQVIPDADDQEWSTKHAY 117

  Fly   189 AGIFHFRFWQYGKWVDVIIDDRLPTYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGST 253
            ||||.||||::||||:|:|||.|||.:|:|::..|...|||||||||||:|||:|.||.|.||..
 Worm   118 AGIFRFRFWRFGKWVEVVIDDLLPTRDGKLLFARSKTPNEFWSALLEKAFAKLYGCYENLVGGHL 182

  Fly   254 CEAMEDFTGGVSEWYD----LKEAPGN----LFTILQKAAERNSMMGCSIEPDPNVTEAETPQ-- 308
            .:|::|.:|||:|...    ||:.|.:    ||..|:.|.::.:::..:|...   |:.|..:  
 Worm   183 SDALQDVSGGVAETLHVRKFLKDDPNDTELKLFNDLKTAFDKGALVVAAIAAR---TKEEIEESL 244

  Fly   309 --GLIRGHAYSITKVCLIDIVTPNRQG----------KIPMIRMRNPWGNEAEWNGPWSDSSPEW 361
              ||::||||:::.||.||:..||.:.          |..:||::|||| |.||||.|||.||||
 Worm   245 DCGLVKGHAYAVSAVCTIDVTNPNERSFTSFIMGSKRKQNLIRLQNPWG-EKEWNGAWSDDSPEW 308

  Fly   362 RYIPEEQKAEIGL----TFDRDGEFWMSFQDFLNHFDRVEICNLSPDSLTEDQQNSGKRKWEMSM 422
            :.:...|.:.:|:    :...||:|||.::.|:::|..:.:|.|...|:.     |..|.::..:
 Worm   309 QNVSASQLSTMGVQPANSDSDDGDFWMPWESFVHYFTDISLCQLFNTSVF-----SFSRSYDEQI 368

  Fly   423 YEGEWT--------PGVTAGGCRNFLDTFWHNPQYIITLVDPDEEDEEGQCTVIVALMQKNRRSK 479
            ...|||        |...||||.||..||.:|||||..:..|:       |:|:.||:|.:....
 Worm   369 VFSEWTTNGKKSGAPDDRAGGCHNFKATFCNNPQYIFDIPSPN-------CSVMFALIQNDPSEG 426

  Fly   480 RNMGMECLTIGFAIYSLNDRELENRPQGLNFFRYKSSVGRSP----HFINTREVCARFK-LPPGH 539
            .......:|||..:     .::||..|      |:......|    .:.:.|.|....: ||.|.
 Worm   427 LKKREPFVTIGMHV-----MKVENNRQ------YRVHTAMHPIAISDYASGRSVYLHLQSLPRGR 480

  Fly   540 YLIVPSTFDPNEEGEFIIRVFSETQNNMEENDDHVGY 576
            ||::|:||.|.|:..|::||:|         |:|:.:
 Worm   481 YLLIPTTFAPKEQTLFMLRVYS---------DEHIHF 508

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CalpANP_001286613.1 Peptidase_C2 104..400 CDD:459889 136/325 (42%)
Calpain_III 416..569 CDD:238132 48/165 (29%)
EFh_PEF_CalpA_B 600..843 CDD:320071
EF-hand motif 600..627 CDD:320071
EF-hand motif 717..747 CDD:320071
EF-hand motif 748..778 CDD:320071
EF-hand motif 784..812 CDD:320071
EF-hand motif 813..843 CDD:320071
tra-3NP_502751.1 CysPc 15..361 CDD:128526 143/354 (40%)
Calpain_III 362..511 CDD:238132 50/174 (29%)
C2_Calpain 526..646 CDD:176011
Blue background indicates that the domain is not in the aligned region.

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