DRSC/TRiP Functional Genomics Resources

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Protein Alignment CalpA and clp-1

DIOPT Version :10

Sequence 1:NP_001286613.1 Gene:CalpA / 37232 FlyBaseID:FBgn0012051 Length:843 Species:Drosophila melanogaster
Sequence 2:NP_498741.3 Gene:clp-1 / 176122 WormBaseID:WBGene00000542 Length:780 Species:Caenorhabditis elegans


Alignment Length:590 Identity:288/590 - (48%)
Similarity:386/590 - (65%) Gaps:56/590 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 GAAKDVVGSVINEI---FIKKEADTKRVLPSIKNMRVQPLQSQSNSTLYYGNLGE---------- 76
            |...:|:|::|.|.   |:..:..|.|::.::....:..|..:.||   .||:|:          
 Worm   204 GGMVNVIGNLIGEAAHRFLGVDPGTGRIIGAVAGNVIMGLGGKDNS---LGNIGKVILDNIISGK 265

  Fly    77 ------------------------KSSSLGPYSEVQDYETILNSCLASGSLFEDPLFPASNESLQ 117
                                    ...|..|.:|.||:..:.:.||.|..|||||.|.|::.||.
 Worm   266 FRRDVDPFVRPGPDPDRGGGGSGPSPISPRPTTEPQDFYELRDQCLESKRLFEDPQFLANDSSLF 330

  Fly   118 FSRRPDRHIEWLRPHEIAENPQFFVEGYSRFDVQQGELGDCWLLAATANLTQESNLFFRVIPAEQ 182
            ||:||.:.:|||||.||...||...||:|||||.||||||||||||.||||.:..||:||:|.:|
 Worm   331 FSKRPPKRVEWLRPGEITREPQLITEGHSRFDVIQGELGDCWLLAAAANLTLKDELFYRVVPPDQ 395

  Fly   183 SFEENYAGIFHFRFWQYGKWVDVIIDDRLPTYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEA 247
            ||.|||||||||:||||||||||:|||||||.||||:||||...|||||||||||||||.|||||
 Worm   396 SFTENYAGIFHFQFWQYGKWVDVVIDDRLPTSNGELLYMHSASNNEFWSALLEKAYAKLFGSYEA 460

  Fly   248 LKGGSTCEAMEDFTGGVSEWYDLKEAPGNLFTILQKAAERNSMMGCSIEPDPNVTEAETPQGLIR 312
            ||||:|.||:||.|||::|:.|||..|.||..::.:..|..|:.|||||.||||.||:...||::
 Worm   461 LKGGTTSEALEDMTGGLTEFIDLKNPPRNLMQMMMRGFEMGSLFGCSIEADPNVWEAKMSNGLVK 525

  Fly   313 GHAYSITKVCLIDIVTPNRQGKIPMIRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFD 377
            |||||||...::|  .||  |:..::|:|||||||.||||||||:|.|||.:|:..|.::||.||
 Worm   526 GHAYSITGCRIVD--GPN--GQTCILRIRNPWGNEQEWNGPWSDNSREWRSVPDSVKQDMGLKFD 586

  Fly   378 RDGEFWMSFQDFLNHFDRVEICNLSPDSLTEDQQNSGKRK----WEMSMYEGEWTPGVTAGGCRN 438
            .||||||||.||:.:|:::|||||.||.:.|..|.:|.:.    |..:.::|.|....|||||||
 Worm   587 HDGEFWMSFDDFMRNFEKMEICNLGPDVMDEVYQMTGVKAAGMVWAANTHDGAWVRNQTAGGCRN 651

  Fly   439 FLDTFWHNPQYIITLVDPDEEDEEGQCTVIVALMQKNRRSKRNMGMECLTIGFAIYSLNDRELEN 503
            :::||.:|||:.:.|.|.|.:|::..||||.|::||.||:.:..|::.:.||||:|...:    |
 Worm   652 YINTFANNPQFRVQLTDSDPDDDDELCTVIFAVLQKYRRNLKQDGLDNVPIGFAVYDAGN----N 712

  Fly   504 RPQ-GLNFFRYKSSVGRSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETQNNM 567
            |.: ...||....|..||..|||.||:..||::|||:|::|||||:||||.||::||::   |..
 Worm   713 RGRLSKQFFAANKSAMRSAAFINLREMTGRFRVPPGNYVVVPSTFEPNEEAEFMLRVYT---NGF 774

  Fly   568 EENDD 572
            .|:::
 Worm   775 IESEE 779

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CalpANP_001286613.1 Peptidase_C2 104..400 CDD:459889 190/295 (64%)
Calpain_III 416..569 CDD:238132 66/157 (42%)
EFh_PEF_CalpA_B 600..843 CDD:320071
EF-hand motif 600..627 CDD:320071
EF-hand motif 717..747 CDD:320071
EF-hand motif 748..778 CDD:320071
EF-hand motif 784..812 CDD:320071
EF-hand motif 813..843 CDD:320071
clp-1NP_498741.3 Peptidase_C2 317..609 CDD:459889 190/295 (64%)
calpain_III 631..778 CDD:214786 67/153 (44%)
Blue background indicates that the domain is not in the aligned region.

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