DRSC/TRiP Functional Genomics Resources

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Protein Alignment CalpA and clp-3

DIOPT Version :10

Sequence 1:NP_001286613.1 Gene:CalpA / 37232 FlyBaseID:FBgn0012051 Length:843 Species:Drosophila melanogaster
Sequence 2:NP_493052.3 Gene:clp-3 / 173089 WormBaseID:WBGene00000544 Length:752 Species:Caenorhabditis elegans


Alignment Length:591 Identity:214/591 - (36%)
Similarity:313/591 - (52%) Gaps:70/591 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 AGQEFLNAAGE--AAMGAAKDVVGSVINEIFIKKEADTKRVLPSIKNMRVQPLQSQSNSTLYYGN 73
            ||.|..|..||  :.....|.|:.::::..| |:|...           ..||..|   .:|:..
 Worm   205 AGNEMFNMGGETNSLSSIGKIVLDNIVSGKF-KRECHV-----------YVPLSCQ---PIYFHE 254

  Fly    74 LGEKSSSLGPYSEVQDYETILNSCLASGSLFEDPLFPASNESLQFSRRPDRHIEWLRPHEIAENP 138
            ..:|                   ||....|||||.|||:|.|:....||..||.|.||.|:..||
 Worm   255 ERQK-------------------CLDEKRLFEDPQFPANNSSIYVKVRPKDHIVWKRPGELFANP 300

  Fly   139 QFFVEGYSRFDVQQGELGDCWLLAATANLTQESNLFFRVIPAEQSFEENYAGIFHFRFWQYGKWV 203
            :......:.|||:.|.|.:.|.|:..|||:....||:||:|.:|||.|.|||||||:||:||:||
 Worm   301 RLIGSDKTHFDVKLGRLENRWFLSGAANLSLRDELFYRVVPPDQSFTEKYAGIFHFQFWRYGEWV 365

  Fly   204 DVIIDDRLPTYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCEAM----EDFTGGV 264
            ||:|||||||.||.|.||.|...:|||..|||||||||.|:||.|....|.:|:    ..||||:
 Worm   366 DVVIDDRLPTVNGTLCYMSSPGGSEFWGPLLEKAYAKLLGTYEHLNDPYTEQALWQASASFTGGL 430

  Fly   265 SEWYDLKEAPG-NLFTILQKAAERNSMMGCSIEPDPNVTEAETPQGLIRGHAYSITKVCLIDIVT 328
            ::|:|:..|.. .:..::.:..:..|::.| :..|.|........|||:|:.|.||.|.|::   
 Worm   431 TQWFDIFMADEMAVLAMIMRGVQMGSLIVC-LNIDVNEKGVRQKNGLIKGYGYCITGVNLME--- 491

  Fly   329 PNRQGKIPMIRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFDRDGEFWMSFQDFLNHF 393
             ....|.|:||:|:||| :.:|.|.:...|..|..:.:|::....:  ..|||||||.:||:..|
 Worm   492 -TEWEKAPLIRIRSPWG-KVKWKGDFCYRSHRWFGLDKEKRESFRI--KEDGEFWMSLKDFMVEF 552

  Fly   394 DRVEICNLSPDSLTEDQQ-------NSGKRKWEMSMYEGEWTPGV-TAGGCRNFLDTFWHNPQYI 450
            ..|..||||.|::.|.::       ....::|..:.:||||:..: |||||.:. |||..|.||.
 Worm   553 TDVYCCNLSADTMHEVEKMTEVKVMEHQSQQWIQASFEGEWSSRIGTAGGCDDH-DTFCTNLQYE 616

  Fly   451 ITLVDPDEEDEEGQCTVIVALMQKNRRSKRNMGMECLTIGFAIYSLNDRELENRPQGLNFFRYKS 515
            |.....|..|...:||:|.||.||||......|:|...||..:|.:.....:..|:   ..:.::
 Worm   617 IHFRATDSYDSNHKCTIIAALFQKNRDHCVYKGLELFLIGLLVYEMPGPNEKVTPE---MVKSQT 678

  Fly   516 SVGRSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETQNNMEENDDH-----VG 575
            .:..|..|.::||...||.:|.|||:|||||:||:::|||::|:|:    |::.:..|     :|
 Worm   679 PIADSKLFKDSREANIRFTVPLGHYVIVPSTYDPDQDGEFLLRIFT----NVDFDKTHALSNGIG 739

  Fly   576 YGGKAD 581
            ...|:|
 Worm   740 LICKSD 745

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CalpANP_001286613.1 Peptidase_C2 104..400 CDD:459889 128/300 (43%)
Calpain_III 416..569 CDD:238132 57/153 (37%)
EFh_PEF_CalpA_B 600..843 CDD:320071
EF-hand motif 600..627 CDD:320071
EF-hand motif 717..747 CDD:320071
EF-hand motif 748..778 CDD:320071
EF-hand motif 784..812 CDD:320071
EF-hand motif 813..843 CDD:320071
clp-3NP_493052.3 MDN1 <7..>127 CDD:444083
CysPc 254..559 CDD:238004 132/331 (40%)
Calpain_III 582..732 CDD:238132 57/157 (36%)
Blue background indicates that the domain is not in the aligned region.

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