DRSC/TRiP Functional Genomics Resources

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Protein Alignment CalpA and CAPN12

DIOPT Version :10

Sequence 1:NP_001286613.1 Gene:CalpA / 37232 FlyBaseID:FBgn0012051 Length:843 Species:Drosophila melanogaster
Sequence 2:XP_054175908.1 Gene:CAPN12 / 147968 HGNCID:13249 Length:723 Species:Homo sapiens


Alignment Length:808 Identity:273/808 - (33%)
Similarity:389/808 - (48%) Gaps:166/808 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly    88 QDYETILNSCLASGSLFEDPLFPASNESLQFSR-RPD----RHIEWLRPHEIAENPQFFVEGYSR 147
            |.||.|..:||.||.||.||.|||..::|.:.: .||    :.::|:||||....|:|..|..||
Human    30 QSYEAIRAACLDSGILFRDPYFPAGPDALGYDQLGPDSEKAKGVKWMRPHEFCAEPKFICEDMSR 94

  Fly   148 FDVQQGELGDCWLLAATANLTQESNLFFRVIPAEQSFEENYAGIFHFRFWQYGKWVDVIIDDRLP 212
            .||.||.||:||.|||.|:||....|..||:|..|.|:..|||:|||:.||:|:|:||::|||||
Human    95 TDVCQGSLGNCWFLAAAASLTLYPRLLRRVVPPGQDFQHGYAGVFHFQLWQFGRWMDVVVDDRLP 159

  Fly   213 TYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCEAMEDFTGGVSEWYDLKEAPGNL 277
            ...|:||::.|.::||||:.||||||||||||||.::||...||..||||||.|...|::....|
Human   160 VREGKLMFVRSEQRNEFWAPLLEKAYAKLHGSYEVMRGGHMNEAFVDFTGGVGEVLYLRQNSMGL 224

  Fly   278 FTILQKAAERNSMMGCSIEPDPNVTEAETPQGLIRGHAYSIT---KVCLIDIVTPNRQG--KIPM 337
            |:.|:.|..:.|::|.:...|..  |..|.:||::|||||||   ||.|         |  |:.:
Human   225 FSALRHALAKESLVGATALSDRG--EYRTEEGLVKGHAYSITGTHKVFL---------GFTKVRL 278

  Fly   338 IRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFDRDGEFWMSFQDFLNHFDRVEICNLS 402
            :|:|||||. .||.|.||||.|.|..:|.|.:..: |....||||||..:|||.|||.|:||:||
Human   279 LRLRNPWGC-VEWTGAWSDSCPRWDTLPTECRDAL-LVKKEDGEFWMELRDFLLHFDTVQICSLS 341

  Fly   403 PDSLTEDQQNSGKRKWEMSMYEGEWTPGVTAGGCRNFLDTFWHNPQYIITLVDPDEEDEEGQ--- 464
            |:.|....:..|   |.:..::|.|..|..:||.:...:|||.|||:.:||::|||||:|.:   
Human   342 PEVLGPSPEGGG---WHVHTFQGRWVRGFNSGGSQPNAETFWTNPQFRLTLLEPDEEDDEDEEGP 403

  Fly   465 --------------------CTVIVALMQKNRRSKRNMGMECLTIGFAIYSLNDR--ELENRPQG 507
                                |||:::|:|:|||..|..|:..||:||.::.:.:.  .|.:.|:.
Human   404 WGGWGAAGARGPARGGRTPKCTVLLSLIQRNRRRLRAKGLTYLTVGFHVFQIPEELLGLWDSPRS 468

  Fly   508 LNFFRYKSSVGRSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETQNNMEENDD 572
            ...........||| ....|:|..|..|.|||||:||||....:|.:|.:|||||.::.      
Human   469 HALLPRLLRADRSP-LSARRDVTRRCCLRPGHYLVVPSTAHAGDEADFTLRVFSERRHT------ 526

  Fly   573 HVGYGGKADTITPGFPTPKPIDPQKEGLRRLFDSIAGKDMEVDWMELKRILDHSMRDDLPKPVVF 637
                                               ||                ..|.|..:|   
Human   527 -----------------------------------AG----------------DRRRDQRRP--- 537

  Fly   638 NRFSNNMAFETQAAGPGDD-------GAGACGLLSLICGPFLKGTPFEEQLGMNDQSNKRLIGDN 695
                        |..||.|       |.|:...|:.                      :...|..
Human   538 ------------AVSPGGDCSWRGGMGRGSWPALNF----------------------RHAAGPL 568

  Fly   696 PADGGPV---------TANAIVDETHGFSKDVCRSMVAMLDADKSGKLGFEEFETLLSEIAKWKA 751
            ||.|..|         .|.|............|..::......:|  |....|:.|...:.:|:|
Human   569 PAPGAGVGAAVSGAGWRARAHTSTPREIGLRTCEQLLQCFGHGQS--LALHHFQQLWGYLLEWQA 631

  Fly   752 IFKVYDVENTGRVSGFQLREALNSAGYHLNNRVLNVLGHRYGSRDGKIAFDDFIMCAVKIKTYID 816
            ||..:|.:.:|.::.::||.|||:||:||||::...|..||.....::.|:.|:.|...: |.|.
Human   632 IFNKFDEDTSGTMNSYELRLALNAAGFHLNNQLTQTLTSRYRDSRLRVDFERFVSCVAHL-TCIF 695

  Fly   817 IFKERDTEKNE-TATFTLEEWIERTIYS 843
            ....:..:..| ....|..:|:|...:|
Human   696 CHCSQHLDGGEGVICLTHRQWMEVATFS 723

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CalpANP_001286613.1 Peptidase_C2 104..400 CDD:459889 145/305 (48%)
Calpain_III 416..569 CDD:238132 59/177 (33%)
EFh_PEF_CalpA_B 600..843 CDD:320071 53/259 (20%)
EF-hand motif 600..627 CDD:320071 2/26 (8%)
EF-hand motif 717..747 CDD:320071 5/29 (17%)
EF-hand motif 748..778 CDD:320071 12/29 (41%)
EF-hand motif 784..812 CDD:320071 6/27 (22%)
EF-hand motif 813..843 CDD:320071 6/30 (20%)
CAPN12XP_054175908.1 Peptidase_C2 46..339 CDD:459889 145/305 (48%)
Calpain_III 352..527 CDD:238132 60/219 (27%)
EFh_PEF 586..723 CDD:355382 36/139 (26%)
EF-hand motif 600..627 CDD:320054 5/28 (18%)
EF-hand motif 628..657 CDD:320054 11/28 (39%)
EF-hand motif 664..692 CDD:320054 6/28 (21%)
EF-hand motif 694..722 CDD:320054 5/27 (19%)

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