DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CalpA and Capn2

DIOPT Version :10

Sequence 1:NP_001286613.1 Gene:CalpA / 37232 FlyBaseID:FBgn0012051 Length:843 Species:Drosophila melanogaster
Sequence 2:NP_033924.2 Gene:Capn2 / 12334 MGIID:88264 Length:700 Species:Mus musculus


Alignment Length:793 Identity:328/793 - (41%)
Similarity:463/793 - (58%) Gaps:133/793 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    76 EKSSSLGPYSEV-----QDYETILNSCLASGSLFEDPLFPASNESLQFSR-----RPDRHIEWLR 130
            |.:..||.:...     |||||:.|.||.:|:||:||.|||...||.:..     ...|.|||.|
Mouse    13 EAAEGLGSHERAIKYLNQDYETLRNECLEAGALFQDPSFPALPSSLGYKELGPYSSKTRGIEWKR 77

  Fly   131 PHEIAENPQFFVEGYSRFDVQQGELGDCWLLAATANLTQESNLFFRVIPAEQSFEENYAGIFHFR 195
            |.||..:|||.:.|.:|.|:.||.|||||||||.|:||....:..||:|.:|||:|||||||||:
Mouse    78 PTEICADPQFIIGGATRTDICQGALGDCWLLAAIASLTLNEEILARVVPPDQSFQENYAGIFHFQ 142

  Fly   196 FWQYGKWVDVIIDDRLPTYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCEAMEDF 260
            |||||:||:|::||||||.:|||:::||.|.:|||||||||||||::|.||||.||:|.|..|||
Mouse   143 FWQYGEWVEVVVDDRLPTKDGELLFVHSAEGSEFWSALLEKAYAKINGCYEALSGGATTEGFEDF 207

  Fly   261 TGGVSEWYDLKEAPGNLFTILQKAAERNSMMGCSIEPDPNVT-----EAETPQGLIRGHAYSITK 320
            |||::|||:|::.|.|||.|:|||.|:.|::||||:    :|     ||.|.|.|::|||||:|.
Mouse   208 TGGIAEWYELRKPPPNLFKIIQKALEKGSLLGCSID----ITSAADSEAVTYQKLVKGHAYSVTG 268

  Fly   321 VCLIDIVTPNRQGKI-PMIRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFDRDGEFWM 384
            ...::     ..|.: .:||:||||| :.||.|.|:|:.|.|..:..|.:|.: .....||||||
Mouse   269 AEEVE-----SSGSLQKLIRIRNPWG-QVEWTGKWNDNCPSWNTVDPEVRANL-TERQEDGEFWM 326

  Fly   385 SFQDFLNHFDRVEICNLSPDSLTEDQQNSGKRKWEMSMYEGEWTPGVTAGGCRNFLDTFWHNPQY 449
            ||.|||.|:.|:|||||:||:||.|..    :||:::..:|.|..|.|||||||:.:|||.||||
Mouse   327 SFSDFLRHYSRLEICNLTPDTLTCDSY----KKWKLTKMDGNWRRGSTAGGCRNYPNTFWMNPQY 387

  Fly   450 IITLVDPDEEDEEGQ--CTVIVALMQKNRRSKRNMGMECLTIGFAIYSLNDRELENRPQ---GLN 509
            :|.|.:.||::|:|:  ||.:|.|:||:||.:|.||.:..||||.||.:.: ||..:..   |.|
Mouse   388 LIKLEEEDEDEEDGERGCTFLVGLIQKHRRRQRKMGEDMHTIGFGIYEVPE-ELTGQTNIHLGKN 451

  Fly   510 FFRYKSSVGRSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETQNNMEENDDHV 574
            ||....:..||..|||.|||..|||||||.|::|||||:|:::|:|.||||||.:.:.:..||.:
Mouse   452 FFLTTRARERSDTFINLREVLNRFKLPPGEYVLVPSTFEPHKDGDFCIRVFSEKKADYQAVDDEI 516

  Fly   575 GYGGKADTITPGFPTPKPIDPQKE----GLRRLFDSIAGKDMEVDWMELKRILDH--SMRDDLPK 633
                :|:.        :.||..:|    |.||||..:||:|.|:...||:.||..  :.|.|:  
Mouse   517 ----EANI--------EEIDANEEDIDDGFRRLFVQLAGEDAEISAFELQTILRRVLAKRQDI-- 567

  Fly   634 PVVFNRFSNNMAFETQAAGPGDDGAGACGLLSLICGPFLKGTPFEEQLGMNDQSNKRLIGDNPAD 698
                                                                             
Mouse   568 ----------------------------------------------------------------- 567

  Fly   699 GGPVTANAIVDETHGFSKDVCRSMVAMLDADKSGKLGFEEFETLLSEIAKWKAIFKVYDVENTGR 763
                       ::.|||.:.|:.||.|||.|.|||||.:||..|.::|.|::.|::..||:.:|.
Mouse   568 -----------KSDGFSIETCKIMVDMLDEDGSGKLGLKEFYILWTKIQKYQKIYREIDVDRSGT 621

  Fly   764 VSGFQLREALNSAGYHLNNRVLNVLGHRYGSRDGKIAFDDFIMCAVKIKTYIDIFKERDTEKNET 828
            ::.:::|:||..||:.|..::..|:..|:...:..|.||:|:.|.|:::|...|||:.|.|...|
Mouse   622 MNSYEMRKALEEAGFKLPCQLHQVIVARFADDELIIDFDNFVRCLVRLETLFKIFKQLDPENTGT 686

  Fly   829 ATFTLEEWIERTI 841
            ....|..|:..::
Mouse   687 IQLNLASWLSFSV 699

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CalpANP_001286613.1 Peptidase_C2 104..400 CDD:459889 161/306 (53%)
Calpain_III 416..569 CDD:238132 78/157 (50%)
EFh_PEF_CalpA_B 600..843 CDD:320071 61/244 (25%)
EF-hand motif 600..627 CDD:320071 12/28 (43%)
EF-hand motif 717..747 CDD:320071 15/29 (52%)
EF-hand motif 748..778 CDD:320071 9/29 (31%)
EF-hand motif 784..812 CDD:320071 8/27 (30%)
EF-hand motif 813..843 CDD:320071 9/29 (31%)
Capn2NP_033924.2 Peptidase_C2 46..342 CDD:459889 161/306 (53%)
Domain III 345..514 83/173 (48%)
Calpain_III 354..512 CDD:238132 78/158 (49%)
Linker 515..529 3/25 (12%)
Domain IV 530..700 62/248 (25%)
EFh_PEF_CAPN2 533..700 CDD:320074 62/245 (25%)
EF-hand motif 533..561 CDD:320074 13/27 (48%)
EF-hand motif 576..605 CDD:320074 15/28 (54%)
EF-hand motif 606..636 CDD:320074 9/29 (31%)
EF-hand motif 642..670 CDD:320074 8/27 (30%)
EF-hand motif 672..700 CDD:320074 8/28 (29%)

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