DRSC/TRiP Functional Genomics Resources

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Protein Alignment CalpA and Capn1

DIOPT Version :10

Sequence 1:NP_001286613.1 Gene:CalpA / 37232 FlyBaseID:FBgn0012051 Length:843 Species:Drosophila melanogaster
Sequence 2:NP_031626.1 Gene:Capn1 / 12333 MGIID:88263 Length:713 Species:Mus musculus


Alignment Length:790 Identity:325/790 - (41%)
Similarity:456/790 - (57%) Gaps:121/790 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    76 EKSSSLGPYSEV-----QDYETILNSCLASGSLFEDPLFPASNESLQFSRRPDRH-----IEWLR 130
            :|...||.:...     |||||:...||.||.||:|..||..:.||.|.......     |:|.|
Mouse    23 DKELGLGRHENAIKYLGQDYETLRARCLQSGVLFQDEAFPPVSHSLGFKELGPHSSKTYGIKWKR 87

  Fly   131 PHEIAENPQFFVEGYSRFDVQQGELGDCWLLAATANLTQESNLFFRVIPAEQSFEENYAGIFHFR 195
            |.|:..||||.|:|.:|.|:.||.|||||||||.|:||....:..||:|..|||::.|||||||:
Mouse    88 PTELMSNPQFIVDGATRTDICQGALGDCWLLAAIASLTLNETILHRVVPYGQSFQDGYAGIFHFQ 152

  Fly   196 FWQYGKWVDVIIDDRLPTYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCEAMEDF 260
            .||:|:||||:|||.|||.:|:|:::||.:.||||||||||||||::||||||.||.|.||.|||
Mouse   153 LWQFGEWVDVVIDDLLPTKDGKLVFVHSAQGNEFWSALLEKAYAKVNGSYEALSGGCTSEAFEDF 217

  Fly   261 TGGVSEWYDLKEAPGNLFTILQKAAERNSMMGCSIE-PDPNVTEAETPQGLIRGHAYSITKVCLI 324
            ||||:|||||::||.:|:.|:.||.||.|::||||. .|....||.|.:.|:||||||:|....:
Mouse   218 TGGVTEWYDLQKAPSDLYQIILKALERGSLLGCSINISDIRDLEAITFKNLVRGHAYSVTGAKQV 282

  Fly   325 DIVTPNRQG-KIPMIRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFDRDGEFWMSFQD 388
                 ..|| ::.:|||||||| |.||.|||||||.||..:...::.::.:..: ||||||||:|
Mouse   283 -----TYQGQRVNLIRMRNPWG-EVEWKGPWSDSSYEWNKVDPYEREQLRVKME-DGEFWMSFRD 340

  Fly   389 FLNHFDRVEICNLSPDSLTEDQQNSGKRKWEMSMYEGEWTPGVTAGGCRNFLDTFWHNPQYIITL 453
            |:..|.::|||||:||:|    ::...|.|..:.|||.|..|.|||||||:..|||.|||:.|.|
Mouse   341 FIREFTKLEICNLTPDAL----KSRTLRNWNTTFYEGTWRRGSTAGGCRNYPATFWVNPQFKIRL 401

  Fly   454 VDPDEEDE----EGQCTVIVALMQKNRRSKRNMGMECLTIGFAIYSLNDRELENRPQGL--NFFR 512
            .:.|:.|:    |..|:.::|||||:||.:|..|.:..|||||:|.: .|||..:|..|  :||.
Mouse   402 EEVDDADDYDNRESGCSFLLALMQKHRRRERRFGRDMETIGFAVYQV-PRELAGQPVHLKRDFFL 465

  Fly   513 YKSSVGRSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETQNNMEENDDHVGYG 577
            ..:|..:|.||||.|||..|.:||||.|::|||||:||:||:|::|.|||.:...:|.||.    
Mouse   466 ANASRAQSEHFINLREVSNRIRLPPGEYIVVPSTFEPNKEGDFLLRFFSEKKAGTQELDDQ---- 526

  Fly   578 GKADTITPGFPTPKPIDPQK--EGLRRLFDSIAGKDMEVDWMELKRILDH--SMRDDLPKPVVFN 638
                 |....|..|.:..::  :..:.||..:||.|||:...||:.||:.  |...||       
Mouse   527 -----IQANLPDEKVLSEEEIDDNFKTLFSKLAGDDMEISVKELQTILNRIISKHKDL------- 579

  Fly   639 RFSNNMAFETQAAGPGDDGAGACGLLSLICGPFLKGTPFEEQLGMNDQSNKRLIGDNPADGGPVT 703
                                                                             
Mouse   580 ----------------------------------------------------------------- 579

  Fly   704 ANAIVDETHGFSKDVCRSMVAMLDADKSGKLGFEEFETLLSEIAKWKAIFKVYDVENTGRVSGFQ 768
                  .|:|||.:.|||||.::|.|.:||||..||..|.:.|..:..||:.:|::.:|.:|.::
Mouse   580 ------RTNGFSLESCRSMVNLMDRDGNGKLGLVEFNILWNRIRNYLTIFRKFDLDKSGSMSAYE 638

  Fly   769 LREALNSAGYHLNNRVLNVLGHRYGSRDGKIAFDDFIMCAVKIKTYIDIFKERDTEKNETATFTL 833
            :|.|:.:||:.||.::..::..||...|..:.||:|:.|.|:::|....||..||:.:...||.|
Mouse   639 MRMAIEAAGFKLNKKLHELIITRYSEPDLAVDFDNFVCCLVRLETMFRFFKLLDTDLDGVVTFDL 703

  Fly   834 EEWIERTIYS 843
            .:|::.|:::
Mouse   704 FKWLQLTMFA 713

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CalpANP_001286613.1 Peptidase_C2 104..400 CDD:459889 161/302 (53%)
Calpain_III 416..569 CDD:238132 77/158 (49%)
EFh_PEF_CalpA_B 600..843 CDD:320071 62/244 (25%)
EF-hand motif 600..627 CDD:320071 11/28 (39%)
EF-hand motif 717..747 CDD:320071 14/29 (48%)
EF-hand motif 748..778 CDD:320071 8/29 (28%)
EF-hand motif 784..812 CDD:320071 8/27 (30%)
EF-hand motif 813..843 CDD:320071 10/29 (34%)
Capn1NP_031626.1 Peptidase_C2 56..352 CDD:459889 161/302 (53%)
Domain III 355..525 81/174 (47%)
Calpain_III 366..523 CDD:238132 76/157 (48%)
Linker 526..541 3/23 (13%)
Domain IV 542..712 62/247 (25%)
EFh_PEF_CAPN1 545..713 CDD:320073 62/245 (25%)
EF-hand motif 545..573 CDD:320073 11/27 (41%)
EF-hand motif 588..617 CDD:320073 14/28 (50%)
EF-hand motif 618..648 CDD:320073 8/29 (28%)
EF-hand motif 654..682 CDD:320073 8/27 (30%)
EF-hand motif 684..713 CDD:320073 9/28 (32%)

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