Protein Alignment CalpA and CAPN11

DIOPT Version :10

• Sequence 1: NP_001286613.1
• Gene: CalpA / 37232
• FlyBaseID: FBgn0012051
• Length: 843
• Species: Drosophila melanogaster
• Sequence 2: XP_011512576.1
• Gene: CAPN11 / 11131
• HGNCID: 1478
• Length: 744
• Species: Homo sapiens
• Alignment Length: 807
• Identity: 317/807 - (39%)
• Similarity: 457/807 - (56%)
• Gaps: 121/807 - (14%)

  Fly    59 QPLQSQSNSTLYYGNLGEKSSSLGPYSEVQD-----YETILNSCLASGSLFEDPLFPASNESLQF 118
            :|..:.:....:..|...|:..:|.:...|:     :|.:..:||..|.|||||||||...||.|
Human    35 EPTFTDTGMVAHINNSRLKAKGVGQHDNAQNFGNQSFEELRAACLRKGELFEDPLFPAEPSSLGF 99

  Fly   119 -----SRRPDRHIEWLRPHEIAENPQFFVEGYSRFDVQQGELGDCWLLAATANLTQESNLFFRVI 178
                 :.:..::|.|.||.:|..||.|.::|.|..|:.||.|||||||||..:||....|.:||:
Human   100 KDLGPNSKNVQNISWQRPKDIINNPLFIMDGISPTDICQGILGDCWLLAAIGSLTTCPKLLYRVV 164

  Fly   179 PAEQSFEENYAGIFHFRFWQYGKWVDVIIDDRLPTYNGELMYMHSTEKNEFWSALLEKAYAKLHG 243
            |..|||::||||||||:.||:|:||:|::||||||.|.:|:::||||::||||||||||||||.|
Human   165 PRGQSFKKNYAGIFHFQIWQFGQWVNVVVDDRLPTKNDKLVFVHSTERSEFWSALLEKAYAKLSG 229

  Fly   244 SYEALKGGSTCEAMEDFTGGVSEWYDLKEAPGNLFTILQKAAERNSMMGCSIE-PDPNVTEAETP 307
            |||||.||||.|.:|||||||::.:.|:..|.||..:|:||.||:|:|||||| ...:..|:.|.
Human   230 SYEALSGGSTMEGLEDFTGGVAQSFQLQRPPQNLLRLLRKAVERSSLMGCSIEVTSDSELESMTD 294

  Fly   308 QGLIRGHAYSITKVCLIDIVTPNRQGKI-PMIRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAE 371
            :.|:||||||:|.  |.|:   :.:||: .:||:||||| ..||||.||||:.||..:..:.:.:
Human   295 KMLVRGHAYSVTG--LQDV---HYRGKMETLIRVRNPWG-RIEWNGAWSDSAREWEEVASDIQMQ 353

  Fly   372 IGLTFDRDGEFWMSFQDFLNHFDRVEICNLSPDSLTEDQQNSGKRKWEMSMYEGEWTPGVTAGGC 436
            : |....|||||||:|||||:|..:|||||:||:|:.|.    |..|..:.|||.|..|.:||||
Human   354 L-LHKTEDGEFWMSYQDFLNNFTLLEICNLTPDTLSGDY----KSYWHTTFYEGSWRRGSSAGGC 413

  Fly   437 RNFLDTFWHNPQYIITLVDPD--EEDEEGQ---CTVIVALMQKNRRSKRNMGMECLTIGFAIYSL 496
            ||...|||.|||:.|:|.:.|  |:|.||.   ||.:|||||||.|..|..|.:..||||.:|::
Human   414 RNHPGTFWTNPQFKISLPEGDDPEDDAEGNVVVCTCLVALMQKNWRHARQQGAQLQTIGFVLYAV 478

  Fly   497 NDRELENRPQGLN----FFRYKSSVGRSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFII 557
             .:|.:| .|.::    ||......|.|..|.|:|||.::.:||||.|:|:||||:|:.:.:|::
Human   479 -PKEFQN-IQDVHLKKEFFTKYQDHGFSEIFTNSREVSSQLRLPPGEYIIIPSTFEPHRDADFLL 541

  Fly   558 RVFSETQNNMEENDDHVGYGG--KADTITPGFPTPKPIDPQKEGLRRLFDSIAGKDMEVDWMELK 620
            |||:|..:...|.|: |.|..  :.:.::.        |...:....||..:||:..|:...||:
Human   542 RVFTEKHSESWELDE-VNYAEQLQEEKVSE--------DDMDQDFLHLFKIVAGEGKEIGVYELQ 597

  Fly   621 RILDHSMRDDLPKPVVFNRFSNNMAFETQAAGPGDDGAGACGLLSLICGPFLKGTPFEEQLGMND 685
            |:|                  |.||.:.::.
Human   598 RLL------------------NRMAIKFKSF---------------------------------- 610

  Fly   686 QSNKRLIGDNPADGGPVTANAIVDETHGFSKDVCRSMVAMLDADKSGKLGFEEFETLLSEIAKWK 750
                                    :|.||..|.||.|:.::|.|.|||||..||:.|..::.||.
Human   611 ------------------------KTKGFGLDACRCMINLMDKDGSGKLGLLEFKILWKKLKKWM 651

  Fly   751 AIFKVYDVENTGRVSGFQLREALNSAGYHLNNRVLNVLGHRYGSRDGKIAFDDFIMCAVKIKTYI 815
            .||:..|.:::|.::.:::|..:..||..|||:|:.||..||...|..|.||.||.|.:::||..
Human   652 DIFRECDQDHSGTLNSYEMRLVIEKAGIKLNNKVMQVLVARYADDDLIIDFDSFISCFLRLKTMF 716

  Fly   816 DIFKERDTEKNETATFTLEEWIERTIY 842
            ..|...|.:.......:||:|::.|::
Human   717 TFFLTMDPKNTGHICLSLEQWLQMTMW 743

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CalpA	NP_001286613.1	Peptidase_C2	104..400	CDD:459889	163/302 (54%)
		Calpain_III	416..569	CDD:238132	70/161 (43%)
		EFh_PEF_CalpA_B	600..843	CDD:320071	61/243 (25%)
		EF-hand motif	600..627	CDD:320071	9/26 (35%)
		EF-hand motif	717..747	CDD:320071	14/29 (48%)
		EF-hand motif	748..778	CDD:320071	8/29 (28%)
		EF-hand motif	784..812	CDD:320071	12/27 (44%)
		EF-hand motif	813..843	CDD:320071	7/30 (23%)
CAPN11	XP_011512576.1	Peptidase_C2	85..381	CDD:459889	163/302 (54%)
		Calpain_III	394..554	CDD:238132	70/161 (43%)
		EFh_PEF	576..744	CDD:355382	61/244 (25%)
		EF-hand motif	576..604	CDD:320068	10/45 (22%)
		EF-hand motif	619..648	CDD:320068	13/28 (46%)
		EF-hand motif	649..678	CDD:320068	7/28 (25%)
		EF-hand motif	685..713	CDD:320068	12/27 (44%)
		EF-hand motif	715..743	CDD:320068	6/27 (22%)