DRSC/TRiP Functional Genomics Resources

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Protein Alignment CalpA and capn8.3

DIOPT Version :10

Sequence 1:NP_001286613.1 Gene:CalpA / 37232 FlyBaseID:FBgn0012051 Length:843 Species:Drosophila melanogaster
Sequence 2:XP_031758475.1 Gene:capn8.3 / 100498169 XenbaseID:XB-GENE-18006552 Length:700 Species:Xenopus tropicalis


Alignment Length:789 Identity:289/789 - (36%)
Similarity:415/789 - (52%) Gaps:130/789 - (16%)


- Green bases have known domain annotations that are detailed below.


  Fly    65 SNSTLYYGNLGEKSSSLGPYSEVQDYETILNSCLASGSLFEDPLFPASNESLQFSR-RPD----R 124
            :|..|.|.|              |||..:...||||.|||||..||||..||.... .||    :
 Frog    21 NNKPLKYLN--------------QDYGQLKAQCLASNSLFEDEPFPASQASLGVKELGPDSDKTK 71

  Fly   125 HIEWLRPHEIAENPQFFVEGYSRFDVQQGELGDCWLLAATANLTQESNLFFRVIPAEQSFEENYA 189
            .|.||||.:|...|:|.:.|.:|.|::||.|||||.|::.|:||.......:|:|.:|||:.|||
 Frog    72 GIVWLRPMQIHPKPEFIISGATRSDIRQGSLGDCWFLSSIASLTLNEEYLSQVVPGDQSFQTNYA 136

  Fly   190 GIFHFRFWQYGKWVDVIIDDRLPTYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGSTC 254
            |||||:|||||:||||::||||||..|:|:::.|.|.|||||||||||||||:||||||.|||..
 Frog   137 GIFHFKFWQYGEWVDVVVDDRLPTKKGKLVFVKSAEGNEFWSALLEKAYAKLNGSYEALIGGSPV 201

  Fly   255 EAMEDFTGGVSEWYDLKEAPGNLFTILQKAAERNSMMGCSIEPDPNVTEAETPQGLIRGHAYSIT 319
            :|:||||||::|.|.|::.|.:||..:||....||::.||.:.|....|......:::.|||:||
 Frog   202 DALEDFTGGIAELYYLEKPPADLFQRVQKVLRANSLLTCSSKSDSGKVETVAKNNVVKNHAYTIT 266

  Fly   320 KVCLIDIVTPNRQGKIPMIRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTFDRDGEFWM 384
            :...:..    |..|:.:||:||||| :.||||.|||::|||..|..|.:|.:....| |||.||
 Frog   267 RAEEVSY----RGEKVQLIRLRNPWG-KTEWNGAWSDNAPEWDDIDSETRAALNTQGD-DGEVWM 325

  Fly   385 SFQDFLNHFDRVEICNLSPDSLTEDQQNSGKRKWEMSMYEGEWTPGVTAGGCRNFLDTFWHNPQY 449
            .|.||::.|.|::|||||.|.:...::    |:|.::.:.|.|..|.|||||:.:.||||.|||:
 Frog   326 PFSDFISEFYRLDICNLSLDCVCSKEE----RRWCLTQFYGSWKSGCTAGGCKKYPDTFWINPQF 386

  Fly   450 IITLVDPDEEDEEGQ---CTVIVALMQKNRRSKRNMGMECLTIGFAIYSLNDRELENRPQ---GL 508
            .|.|.:||:|...|:   |||||||:|||||..:..|.|...:|:.:|.: .:||:..|.   |.
 Frog   387 RIKLEEPDDERGAGKAQSCTVIVALIQKNRRKMKPTGGEEFAVGYYLYPI-PKELQGSPDVPLGK 450

  Fly   509 NFFRYKSSVGRSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETQNNMEENDDH 573
            :||.....|..:..:...||.|.|.|||.|.|:::|.|:.|.:|.:|.:|||||.:         
 Frog   451 DFFLKTKYVAWTDVYKKHRETCCRHKLPVGEYVLLPHTYYPCQEADFCLRVFSEKK--------- 506

  Fly   574 VGYGGKADTITPGFPTPKPIDPQKEG-LRRLFDSIAGKDMEVDWMELK----RILDHSMRDDLPK 633
            ||.....|............|.|.|. :..:...:..:.||:...||:    |||  |.|.|:  
 Frog   507 VGVWELGDVANADLYQLDVSDIQVESEIGDILTELEQQKMEMSAEELRINLSRIL--SKRKDI-- 567

  Fly   634 PVVFNRFSNNMAFETQAAGPGDDGAGACGLLSLICGPFLKGTPFEEQLGMNDQSNKRLIGDNPAD 698
                                                                             
 Frog   568 ----------------------------------------------------------------- 567

  Fly   699 GGPVTANAIVDETHGFSKDVCRSMVAMLDADKSGKLGFEEFETLLSEIAKWKAIFKVYDVENTGR 763
                       ::.|||...|:.|:.:.|.|.:|||.::||..|..::.|:..|||..|.:.:..
 Frog   568 -----------KSDGFSLTTCKEMINLFDTDLTGKLSYKEFRPLWIKLVKYTKIFKSADNDRSES 621

  Fly   764 VSGFQLREALNSAGYHLNNRVLNVLGHRYGSRDGKIAFDDFIMCAVKIKTYIDIFKERDTEKNET 828
            :...::|.||..||::|||::...:..||.:....|:||.||.|.::::|...:|:...|.:|..
 Frog   622 IEAHEMRNALQQAGFNLNNKIQEAIVQRYITNGLSISFDSFIACLIRLETLFKMFELLKTNENGA 686

  Fly   829 ATFTLEEWI 837
            .:.:|.||:
 Frog   687 LSLSLSEWL 695

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CalpANP_001286613.1 Peptidase_C2 104..400 CDD:459889 149/300 (50%)
Calpain_III 416..569 CDD:238132 65/158 (41%)
EFh_PEF_CalpA_B 600..843 CDD:320071 51/242 (21%)
EF-hand motif 600..627 CDD:320071 7/30 (23%)
EF-hand motif 717..747 CDD:320071 10/29 (34%)
EF-hand motif 748..778 CDD:320071 9/29 (31%)
EF-hand motif 784..812 CDD:320071 8/27 (30%)
EF-hand motif 813..843 CDD:320071 7/25 (28%)
capn8.3XP_031758475.1 Peptidase_C2 46..341 CDD:459889 149/300 (50%)
Calpain_III 360..502 CDD:460050 59/142 (42%)
EFh_PEF 533..700 CDD:355382 51/243 (21%)
EF-hand motif 533..561 CDD:320054 5/27 (19%)
EF-hand motif 576..605 CDD:320054 10/28 (36%)
EF-hand motif 606..635 CDD:320054 8/28 (29%)
EF-hand motif 642..670 CDD:320054 8/27 (30%)
EF-hand motif 672..700 CDD:320054 6/24 (25%)

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