DRSC/TRiP Functional Genomics Resources

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Protein Alignment CalpA and LOC100495980

DIOPT Version :10

Sequence 1:NP_001286613.1 Gene:CalpA / 37232 FlyBaseID:FBgn0012051 Length:843 Species:Drosophila melanogaster
Sequence 2:XP_017952054.2 Gene:LOC100495980 / 100495980 XenbaseID:XB-GENE-29082919 Length:737 Species:Xenopus tropicalis


Alignment Length:804 Identity:308/804 - (38%)
Similarity:442/804 - (54%) Gaps:138/804 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    61 LQSQSNSTLYYGNLGEKSSSLGPYSEVQDYETILNSCLASGSLFEDPLFPASNESLQFSR----- 120
            ||.:.||:..:        ::.||.. |||..::..||....|||||.|||.::||.::.     
 Frog    10 LQKEENSSARH--------NVSPYLG-QDYHRLVQECLKQRQLFEDPHFPAKSKSLGYNELGPFS 65

  Fly   121 RPDRHIEWLRPHEIAENPQFFVEGYSRFDVQQGELGDCWLLAATANLTQESNLFFRVIPAEQSFE 185
            ...:.|:|.||.||.::|||..|.....||.|||||:||.|||.|:|||...|..||:|.:|||:
 Frog    66 ENTKGIQWRRPQEICQSPQFICEDMKWTDVCQGELGNCWFLAAAASLTQYPLLKERVVPPQQSFK 130

  Fly   186 ENYAGIFHFRFWQYGKWVDVIIDDRLPTYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKG 250
            ..|||||||:|||||:||||::|||||...|||:::.|.:|:|||:||||||||||:||||||.|
 Frog   131 SGYAGIFHFQFWQYGEWVDVVVDDRLPVKEGELVFVSSAQKSEFWAALLEKAYAKLNGSYEALNG 195

  Fly   251 GSTCEAMEDFTGGVSEWYDLKEAPGNLFTILQKAAERNSMMGCSIEP-DPNVTEAETPQGLIRGH 314
            |...||..|||||:.|...|||.|.|||.:||||.::.|:||..|:| ..:..|.:||:||:.||
 Frog   196 GFMNEAFVDFTGGLGETVKLKETPPNLFHLLQKAVKKKSLMGAFIQPQSQSQIENQTPEGLLTGH 260

  Fly   315 AYSITKVCLIDIVT---PNRQGKIPMIRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGLTF 376
            ||||       |.|   .|...|||::|:||||| ..||||.|||.|..|..:..|.:.::.:. 
 Frog   261 AYSI-------IATWEMKNNGKKIPLLRLRNPWG-RVEWNGHWSDDSTLWSQVDPEIRKKLQVR- 316

  Fly   377 DRDGEFWMSFQDFLNHFDRVEICNLSPDSLTEDQQNSGKRKWEMSMYEGEWTPGVTAGGCRNFLD 441
            ..||||||..:|||..||.:|:|||:|:|:|:..    .:.|:.:.:.|.|. |.:|||||.:.|
 Frog   317 GEDGEFWMQMEDFLRFFDILEVCNLTPESVTDKH----AQLWKTNTFCGRWL-GHSAGGCRTYKD 376

  Fly   442 TFWHNPQYIITLVDPDEEDEEGQCTVIVALMQKNRRSKRNMGMECLTIGFAIYSLNDRELENR-- 504
            |||.|||:::||.:.||| :.|.||::|:|||||||..|::|.:.|::||.||.: .:|.:|:  
 Frog   377 TFWTNPQFLVTLTEQDEE-KHGMCTLLVSLMQKNRRQCRSIGQDFLSVGFEIYQV-PKEFDNKMC 439

  Fly   505 -PQGLNFFRYKSSVGRSPHFINTREVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETQNNME 568
             .:..|.|....||. |..|::.|:|..|::||||.||::||||.|::|.:||:|:|:|.|:...
 Frog   440 ASERKNLFSSLVSVA-SCSFMDERDVTGRYQLPPGRYLLIPSTFQPHQESDFIMRIFTEKQHTFI 503

  Fly   569 ENDDHVGYGGKA-------DTITPGFPTPKPIDPQKEGLRRLFDSIAGKDMEVDWMELKRILDHS 626
            |.|..:...|..       ||:              |.....|..::|:|.|:...||:|||.. 
 Frog   504 EIDCEIRANGNVFKENALKDTM--------------EEFSAQFARLSGEDQEISPEELQRILIQ- 553

  Fly   627 MRDDLPKPVVFNRFSNNMAFETQAAGPGDDGAGACGLLSLICGPFLKGTPFEEQLGMNDQSNKRL 691
                                                                             
 Frog   554 ----------------------------------------------------------------- 553

  Fly   692 IGDNPADGGPVTANAIVDETHGFSKDVCRSMVAMLDADKSGKLGFEEFETLLSEIAKWKAIFKVY 756
                      :|:.....:|:|||.|:||.:|.|:|.:.:|||..|||..|.|:|.:|:.||..|
 Frog   554 ----------ITSKNTHLKTNGFSLDICRKLVKMVDLNCNGKLQLEEFRKLWSKIKEWEKIFTNY 608

  Fly   757 DVENTGRVSGFQLREALNSAGYHLNNRVLNVLGHRYGSRDGKIAFDDFIMCAVKIKTYIDIFKER 821
            |.:.:|.:...:|..||.:||:.|||:::..|..:||:...::.||.|:.|...:....:..:..
 Frog   609 DKDRSGTMDVQELCLALEAAGFTLNNQLVESLCQKYGNNVRQVYFDSFLSCLAYLVCVFEQCRIM 673

  Fly   822 DTEKNETATFTLEE---WIERTIY 842
            |..|:.....:.||   :|:.|||
 Frog   674 DKNKDGVICISKEEASIYIKGTIY 697

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CalpANP_001286613.1 Peptidase_C2 104..400 CDD:459889 158/304 (52%)
Calpain_III 416..569 CDD:238132 68/155 (44%)
EFh_PEF_CalpA_B 600..843 CDD:320071 58/246 (24%)
EF-hand motif 600..627 CDD:320071 9/26 (35%)
EF-hand motif 717..747 CDD:320071 14/29 (48%)
EF-hand motif 748..778 CDD:320071 10/29 (34%)
EF-hand motif 784..812 CDD:320071 7/27 (26%)
EF-hand motif 813..843 CDD:320071 8/33 (24%)
LOC100495980XP_017952054.2 Peptidase_C2 44..340 CDD:459889 158/304 (52%)
Calpain_III 361..495 CDD:460050 64/137 (47%)
EFh_PEF 527..687 CDD:355382 52/235 (22%)
EF-hand motif 527..555 CDD:320054 9/103 (9%)
EF-hand motif 570..599 CDD:320054 13/28 (46%)
EF-hand motif 600..629 CDD:320054 9/28 (32%)
EF-hand motif 636..664 CDD:320054 7/27 (26%)

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