DRSC/TRiP Functional Genomics Resources

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Protein Alignment CalpA and capn10

DIOPT Version :10

Sequence 1:NP_001286613.1 Gene:CalpA / 37232 FlyBaseID:FBgn0012051 Length:843 Species:Drosophila melanogaster
Sequence 2:XP_002935183.3 Gene:capn10 / 100379827 XenbaseID:XB-GENE-5770563 Length:640 Species:Xenopus tropicalis


Alignment Length:681 Identity:186/681 - (27%)
Similarity:280/681 - (41%) Gaps:153/681 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   103 LFEDPLFPASNESL------QFSRRPDRHIEWLRPHEIAENPQFFVEGYSRFDV-QQGELGDCWL 160
            ||.|..|||...||      |.|...| :|.|.||.:|..:|..|.| .:|.:: :||.|||||.
 Frog     8 LFVDSDFPAHVSSLVHGGDTQLSLHSD-NISWQRPLDICASPSLFSE-KNRLNLGKQGILGDCWF 70

  Fly   161 LAATANLTQESNLFFRVIPAEQS--FEENYAGIFHFRFWQYGKWVDVIIDDRLPTYNGELMYMHS 223
            :.|...|.:...|..:|.||.|.  ...||.|.|..|||::|.||:|.|||.||....:|.:.|.
 Frog    71 ICACTALQKYDRLLGQVFPAGQCTWTNSNYLGQFTCRFWRFGCWVEVTIDDNLPCLGNKLCFSHC 135

  Fly   224 TEKNEFWSALLEKAYAKLHGSYEALKGGSTCEAMEDFTGGVSEWYDLKEAPG----NLFTILQKA 284
            .::..||..|||||||||||.||||..|...:|:.|.|||:.|.:.|:....    .||:.|...
 Frog   136 QDQGAFWLPLLEKAYAKLHGCYEALWAGQVADALVDLTGGLVERWSLESEDDRGREKLFSKLVSL 200

  Fly   285 AERNSMMGCSIEPDPNVTEAETPQGLIRGHAYSITKVCLIDIVTPNRQGKIPMIRMRNPWGNEAE 349
            .:|.:|. ||:     :...:....|...|||:||.:  ..:||.:.:..: ::|:.|||| .:.
 Frog   201 KDRCAMC-CSV-----LHNRDRVMELGELHAYTITDI--QHVVTKSCKDLL-LLRLHNPWG-RSS 255

  Fly   350 WNGPWSDSSPEWRYIPEEQKAEIGLTFDRDGEFWMSFQDFLNHFDRVEICNLSPDSLTEDQQNSG 414
            |.|.|......|..:..:..|.: |:..::||||:..|:||..||.:.|      :.....:...
 Frog   256 WAGSWRKGGDGWNDLNLKDSARL-LSEVQEGEFWVEKQEFLQEFDEITI------AFPYSHEGHL 313

  Fly   415 KRKW------EMSMYEGEWTPGVTAGGCRNFLDTFWHNPQYIITLVDPDEEDEEGQCTVIVALMQ 473
            :..|      ....:.|.|..|.:|||.||.: :|..||::.:.:.:|.|        |.::|||
 Frog   314 QSIWTDLPLLHKQQFYGSWVKGYSAGGSRNNV-SFPENPKFWLRVKEPSE--------VFLSLMQ 369

  Fly   474 --------------KNRRSKRNMGMECLTIGFAIYSLNDRELENRPQGLNFFRYK-----SSV-- 517
                          ..||:.|:.......:|..::.:..|            |:|     ||:  
 Frog   370 IPQGGVKIPEPVHGVYRRNLRHNKTAINAVGIHVWKVEKR------------RFKLQKTLSSLPL 422

  Fly   518 -GRSPHFINTR-EVCARFKLPPGHYLIVPSTFDPNEEGEFIIRVFSETQNNMEENDDHVGYGGKA 580
             |.|.|..:.: .:|.  .|.||:||::||.|....||.|::|:.|.....:.|           
 Frog   423 AGTSSHCYDRQLHLCC--NLSPGYYLLIPSIFLREAEGNFLLRILSTGNFTLSE----------- 474

  Fly   581 DTITPGFPTPKPIDPQKEGLRRLFDSIAGKDMEVDWMELKRILDHSMRDDLPKPVVFNRFSNNMA 645
              ..|.:..|.                |..|:.....|.:.:.....:                 
 Frog   475 --CAPSWNIPS----------------ANADLTCGMWETQELSGQWKK----------------- 504

  Fly   646 FETQAAGPGDDGAGACGLLSLI---CGPFL--KGTPFEEQL--GMNDQSNKRLIGDNPADGGPVT 703
                    |.:..|:....|.|   |.||.  .|||..:.:  ..:|......||.:..   |||
 Frog   505 --------GSNAGGSRNFASHIINPCFPFSVPDGTPMIKLMLRQQHDGEKCHAIGFHVY---PVT 558

  Fly   704 ANAIVDETHGFSKDVCRSMVAMLDADKSGKL 734
            :|..|     ||.:.|...:......:..||
 Frog   559 SNQSV-----FSLEPCVKCIPHSHCQEVSKL 584

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CalpANP_001286613.1 Peptidase_C2 104..400 CDD:459889 112/308 (36%)
Calpain_III 416..569 CDD:238132 44/181 (24%)
EFh_PEF_CalpA_B 600..843 CDD:320071 26/142 (18%)
EF-hand motif 600..627 CDD:320071 3/26 (12%)
EF-hand motif 717..747 CDD:320071 3/18 (17%)
EF-hand motif 748..778 CDD:320071
EF-hand motif 784..812 CDD:320071
EF-hand motif 813..843 CDD:320071
capn10XP_002935183.3 Peptidase_C2 9..303 CDD:459889 111/306 (36%)
calpain_III 324..473 CDD:214786 43/171 (25%)
Calpain_III 493..624 CDD:469636 24/125 (19%)
Blue background indicates that the domain is not in the aligned region.

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