DRSC/TRiP Functional Genomics Resources

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Protein Alignment CalpA and capn15

DIOPT Version :10

Sequence 1:NP_001286613.1 Gene:CalpA / 37232 FlyBaseID:FBgn0012051 Length:843 Species:Drosophila melanogaster
Sequence 2:XP_031748342.1 Gene:capn15 / 100127702 XenbaseID:XB-GENE-5926484 Length:1051 Species:Xenopus tropicalis


Alignment Length:543 Identity:144/543 - (26%)
Similarity:207/543 - (38%) Gaps:130/543 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    90 YETILNSCLASGSL---------FEDPLFPASNESLQFSRRPD---RHIEWLRPHEIAENPQFFV 142
            :|.|::.|....|.         |.|..||....|:.|.....   |..:||||.||  |...|.
 Frog   427 WENIVSFCRDLSSYLSPSQNTVNFVDDSFPPGPRSVGFPETDSVQLRVKQWLRPQEI--NCSSFK 489

  Fly   143 EGYSRF---------DVQQGELGDCWLLAATANLTQESNLFFRVIPAEQSFEENYAGIFHFRFWQ 198
            |...::         |:.||.||:||.|:|.|.|.:...|..||:.......|   |.:..|..:
 Frog   490 ERSVKWTVFRTPRPSDILQGLLGNCWFLSALAVLAERPELVERVMITRTICPE---GAYQVRLCK 551

  Fly   199 YGKWVDVIIDDRLPTYNGELMYMHSTEKNEFWSALLEKAYAKLHGSYEALKGGSTCEAMEDFTGG 263
            .|.|..|::||.||......:.....::.:.|.||:|||.|||||||.||:.|...|.:...||.
 Frog   552 DGTWTTVLVDDMLPCDEAGYLLFSQAQRKQLWVALIEKALAKLHGSYFALQAGRAIEGLATLTGA 616

  Fly   264 VSEWYDLKEAPGN----------LFTILQKAAERNSMMGCS-----IEPD----PNVTEAETPQG 309
            ..|...|:.:..|          ::..:..:.|...:||.|     ::.|    .||       |
 Frog   617 PCESLMLQVSSTNPREENVDTDLIWAKMLSSKEAGFLMGASCGGGNMKVDDIAYENV-------G 674

  Fly   310 LIRGHAYSITKVCLIDIVTPNRQGKIPMIRMRNPWGNEAEWNGPWSDSSPEWRYIPEEQKAEIGL 374
            |...|||||..|  .|:     || ..::|:||||| ...|||.|||   ||...|...|.|:..
 Frog   675 LRPRHAYSILDV--RDV-----QG-FRLLRLRNPWG-RFSWNGSWSD---EWSQWPASLKHELMP 727

  Fly   375 TFDRDGEFWMSFQDFLNHFDRVEICNLSPDSLTEDQQNSGKRKWEMSMYEGEWTPGVTAGGCRNF 439
            ....:|.|||.:.||:.:||.|:||.:..|             |.....:|              
 Frog   728 HGSSEGVFWMEYNDFIRYFDSVDICKIHTD-------------WHEVRVQG-------------- 765

  Fly   440 LDTFWHNPQYIITLVDPDEEDEEGQCTVI------VALMQKNRRSKRNMGME----CLTIGFAIY 494
              ||.:.....:|:.         ..||:      .:|.|:..|....:...    |:.:..|.:
 Frog   766 --TFPNKASVPVTVT---------SLTVVERTAMEFSLFQEGSRRSDTVDSHLLDLCIMVFRASH 819

  Fly   495 SLNDRELENRPQGLNFFRYKSSVGRSPHFINTREVCARFKLPPGHYLIVPSTFDPNE----EGEF 555
            |.:.:.:..|....:....|..||            ....|.||.|.:|...|:..:    .|..
 Frog   820 SGSGKVMLGRLMAHSKRAVKKFVG------------CDVMLEPGEYAVVCCAFNHWQTLMAAGSS 872

  Fly   556 IIRVFSET--QNNMEENDDHVGY 576
            ..:..|.|  .||.....|.:||
 Frog   873 PAQASSPTGSSNNRRAASDALGY 895

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CalpANP_001286613.1 Peptidase_C2 104..400 CDD:459889 107/326 (33%)
Calpain_III 416..569 CDD:238132 28/168 (17%)
EFh_PEF_CalpA_B 600..843 CDD:320071
EF-hand motif 600..627 CDD:320071
EF-hand motif 717..747 CDD:320071
EF-hand motif 748..778 CDD:320071
EF-hand motif 784..812 CDD:320071
EF-hand motif 813..843 CDD:320071
capn15XP_031748342.1 RanBP2-type Zn finger 67..86 CDD:275375
RanBP2-type Zn finger 107..132 CDD:275375
PHA03247 <140..390 CDD:223021
RanBP2-type Zn finger 178..197 CDD:275375
RanBP2-type Zn finger 255..274 CDD:275375
RanBP2-type Zn finger 312..331 CDD:275376
RanBP2-type Zn finger 368..387 CDD:275376
Peptidase_C2 450..753 CDD:459889 107/326 (33%)
Blue background indicates that the domain is not in the aligned region.

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