Protein Alignment hts and ADD1

DIOPT Version :10

• Sequence 1: NP_001097377.2
• Gene: hts / 37230
• FlyBaseID: FBgn0263391
• Length: 1833
• Species: Drosophila melanogaster
• Sequence 2: NP_001341690.1
• Gene: ADD1 / 118
• HGNCID: 243
• Length: 799
• Species: Homo sapiens
• Alignment Length: 805
• Identity: 269/805 - (33%)
• Similarity: 393/805 - (48%)
• Gaps: 172/805 - (21%)

  Fly     4 VEQPPQNGIDPTAGE---------DDDN-----SKARPADIEQDMREMERRKRVEAIMGSKLFRE 54
            |..||     ||...         |::|     .:....|:.||...||::|||..|:.|..|.|
Human    10 VTSPP-----PTTAPHKERYFDRVDENNPEYLRERNMAPDLRQDFNMMEQKKRVSMILQSPAFCE 69

  Fly    55 ELERIVDSARDGGAGASGI--LQQLSDIV---------GVPVSRVGSVFKSSNCMVPINDIRGVE 108
            |||.::......|...:|:  |||::|.:         ..|...:.::..|...:.|:||:||.:
Human    70 ELESMIQEQFKKGKNPTGLLALQQIADFMTTNVPNVYPAAPQGGMAALNMSLGMVTPVNDLRGSD 134

  Fly   109 SMGYAKGEKILRCKLAATFRLLDLYGWTQGLGAQITARLKVDQEYFLVNPYGLLYHEITASALNK 173
            |:.|.||||:|||||||.:||.||:||:|.:...||.|:..:||:||:.|:||||.|:|||:|.|
Human   135 SIAYDKGEKLLRCKLAAFYRLADLFGWSQLIYNHITTRVNSEQEHFLIVPFGLLYSEVTASSLVK 199

  Fly   174 VDMQGQIVEQGTTNFGGNKSHFVLHSVVHAARPDIRCAIYIGCSPVVAISSLKTGLLPLTKDACV 238
            :::||.||::|:||.|.|::.|.|||.::|||||::|.::|......|:|::|.||||::.:|..
Human   200 INLQGDIVDRGSTNLGVNQAGFTLHSAIYAARPDVKCVVHIHTPAGAAVSAMKCGLLPISPEALS 264

  Fly   239 LGEITTHAYTG-LFDEEERNRLVRSLGPNSKVILLTNHGALCCGETIEEAFFAACHIVQACETQL 302
            |||:..|.|.| |.||||:..:.::|||.|||::|.|||.:..||::||||:...::|.|||.|:
Human   265 LGEVAYHDYHGILVDEEEKVLIQKNLGPKSKVLILRNHGLVSVGESVEEAFYYIHNLVVACEIQV 329

  Fly   303 KLLPV--GLDNLVLIPEESRKAIYEQSRRPPEDLEKKFAAVAAAEDGAATAEKDAAEAVPKVGSP 365
            :.|..  |.|||||:..|..||   :||.|                |:...|        ..|||
Human   330 RTLASAGGPDNLVLLNPEKYKA---KSRSP----------------GSPVGE--------GTGSP 367

  Fly   366 PKWRVGGAEFEALMRMLDNAGYRTGYIYRHPLIKSDPPKPKNDVELPPAVSSLGYLLEEEELFRQ 430
            |||::|..|||||||||||.||||||.||:|.:: :..|..:|||:|.:|:  ||....:
Human   368 PKWQIGEQEFEALMRMLDNLGYRTGYPYRYPALR-EKSKKYSDVEVPASVT--GYSFASD----- 424

  Fly   431 GIWKKGDI-----------RKGGDRSRWLN---------------SPNVYQKV------------ 457
                 ||.           ::..:::||||               ||....||
Human   425 -----GDSGTCSPLRHSFQKQQREKTRWLNSGRGDEASEEGQNGSSPKSKTKVWTNITHDHVKPL 484

  Fly   458 -EVLETGTPDPKKITK--WVAE-GSPTHSTPVRIEDPLQFVPAGTNPREFKRVQQLIKDNRRADK 518
             :.|.:|...|..||.  |..| |..|.::.|    |..|||..|||:|.:.::..|::....|.
Human   485 LQSLSSGVCVPSCITNCLWTKEDGHRTSTSAV----PNLFVPLNTNPKEVQEMRNKIREQNLQDI 545

  Fly   519 ISAGPQSHILEGVTWD----------------EASRLKDATVSQAGDHVVMMG---AASKGIIQR 564
            .:|||||.:|.||..|                |...|.:.|.|.|.......|   .|||.||::
Human   546 KTAGPQSQVLCGVVMDRSLVQDAPLSDCTETIEGLELTEQTFSPAKSLSFRKGELVTASKAIIEK 610

  Fly   565 GFQHNATVYKAPYAKNPFDNVTDDELNEYKRTVERKKKSVHGEYTDTDFSESEAVLQAGTKKYPQ 629
            .:|.:..|  :....|||..:||.||.||:|.||||:|   |...:.|.:..:      .:|.|.
Human   611 EYQPHVIV--STTGPNPFTTLTDRELEEYRREVERKQK---GSEENLDEAREQ------KEKSPP 664

  Fly   630 SEPETEH----QVIEIQTQQAPVPRQAEVVLSDD-----------DSKNNEYGDDMENQLYERNR 679
            .:|...|    ..|:::....|.|     ...||           |...:|..:.:...:.|:..
Human   665 DQPAVPHPPPSTPIKLEEDLVPEP-----TTGDDSDAATFKPTLPDLSPDEPSEALGFPMLEKEE 724

  Fly   680 NVHNNSKCRRDLFATKRRDPHPSPE 704
            ..|.......   |.....|.|:|:
Human   725 EAHRPPSPTE---APTEASPEPAPD 746

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
hts	NP_001097377.2	Aldolase_II	116..323	CDD:238232	103/209 (49%)
ADD1	NP_001341690.1	Aldolase_II	145..391	CDD:469663	127/272 (47%)
		PHA03307	647..>770	CDD:223039	19/114 (17%)